KEGG   DRUG: D00616Help
Entry
D00616                      Drug                                   

Name
Diltiazem hydrochloride (JP16/USP);
Cardizem (TN);
Cartia XT (TN);
Dilacor XR (TN);
Dilt-CD (TN)
Product
  Generic
DILTIAZEM HYDROCHLORIDE (Physicians Total Care), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions LLC), DILTIAZEM HYDROCHLORIDE (Actavis Elizabeth LLC), DILTIAZEM HYDROCHLORIDE (Actavis Elizabeth LLC), DILTIAZEM HYDROCHLORIDE (Actavis Elizabeth LLC), DILTIAZEM HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), DILTIAZEM HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), DILTIAZEM HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), DILTIAZEM HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), DILTIAZEM HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), DILTIAZEM HYDROCHLORIDE (Akorn), DILTIAZEM HYDROCHLORIDE (Akorn), DILTIAZEM HYDROCHLORIDE (Akorn), DILTIAZEM HYDROCHLORIDE (American Health Packaging), DILTIAZEM HYDROCHLORIDE (American Health Packaging), DILTIAZEM HYDROCHLORIDE (American Health Packaging), DILTIAZEM HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), DILTIAZEM HYDROCHLORIDE (Apotex Corp.), DILT-CD (Apotex Corp.), DILTZAC (Apotex Corp.), DILTIAZEM HYDROCHLORIDE (AvKARE), DILTIAZEM HYDROCHLORIDE (Baxter Healthcare Corporation), DILTIAZEM HYDROCHLORIDE (Bedford Laboratories), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Cardinal Health), DILTIAZEM HYDROCHLORIDE (Cardinal Health), DILTIAZEM HYDROCHLORIDE (Cardinal Health), DILTIAZEM HYDROCHLORIDE (Cardinal Health), DILTIAZEM HYDROCHLORIDE (Cardinal Health), DILTIAZEM HYDROCHLORIDE (Carilion Materials Management), DILTIAZEM HYDROCHLORIDE (Carilion Materials Management), DILTIAZEM HYDROCHLORIDE (Carilion Materials Management), DILTIAZEM HYDROCHLORIDE (Carilion Materials Management), DILTIAZEM HYDROCHLORIDE (Dispensing Solutions), DILTIAZEM HYDROCHLORIDE (Dispensing Solutions), DILTIAZEM HYDROCHLORIDE (Dispensing Solutions), DILTIAZEM HYDROCHLORIDE (Forest Laboratories), DILTIAZEM HYDROCHLORIDE (Hospira), DILTIAZEM HYDROCHLORIDE (Hospira), DILTIAZEM HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), DILTIAZEM HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), DILTIAZEM HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), DILTIAZEM HYDROCHLORIDE (Major Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (McKesson Contract Packaging), DILTIAZEM HYDROCHLORIDE (McKesson Packaging Services Business Unit of McKesson Corporation), DILTIAZEM HYDROCHLORIDE (McKesson Packaging Services Business Unit of McKesson Corporation), DILTIAZEM HYDROCHLORIDE (McKesson Packaging Services Business Unit of McKesson Corporation), DILTIAZEM HYDROCHLORIDE (Mylan Institutional), DILTIAZEM HYDROCHLORIDE (Mylan Institutional), DILTIAZEM HYDROCHLORIDE (Mylan Institutional), DILTIAZEM HYDROCHLORIDE (Mylan Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Mylan Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Mylan Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (NCS HealthCare of KY), DILTIAZEM HYDROCHLORIDE (NCS HealthCare of KY), DILTIAZEM HYDROCHLORIDE EXTENDED RELEASE (NCS HealthCare of KY), DILTIAZEM HCL CD (Oceanside Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (PD-Rx Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (PD-Rx Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (PD-Rx Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Par Pharmaceutical), DILTIAZEM HYDROCHLORIDE (Physicians Total Care), DILTIAZEM HYDROCHLORIDE (Physicians Total Care), DILTIAZEM HYDROCHLORIDE (Preferred Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDEEXTENDED RELEASE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDEEXTENDED RELEASE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (Rebel Distributors Corp), DILTIAZEM HYDROCHLORIDE (Rebel Distributors Corp), DILTIAZEM HYDROCHLORIDE (Sandoz), DILTIAZEM HYDROCHLORIDE (St Marys Medical Park Pharmacy), DILTIAZEM HYDROCHLORIDE (State of Florida DOH Central Pharmacy), DILTIAZEM HYDROCHLORIDE (State of Florida DOH Central Pharmacy), DILTIAZEM HYDROCHLORIDE (State of Florida DOH Central Pharmacy), DILTIAZEM HYDROCHLORIDE (Sun Pharma Global FZE), DILTIAZEM HYDROCHLORIDE (Sun Pharma Global FZE), DILTIAZEM HYDROCHLORIDE (TEVA Pharmaceuticals USA), DILTIAZEM HYDROCHLORIDE (Teva Pharmaceuticals USA), DILTIAZEM HYDROCHLORIDE (Unit Dose Services), CARTIA (Watson Pharma), DILTIAZEM HYDROCHLORIDE (Watson Pharma), TAZTIA (Watson Pharma), DILACOR (Watson Pharma), MATZIM LA (Watson Pharma), DILTIAZEM HYDROCHLORIDE (West-ward Pharmaceutical Corp.), DILTIAZEM HYDROCHLORIDE (Oceanside Pharmaceuticals)
  Other
Formula
C22H26N2O4S. HCl
Exact mass
450.138
Mol weight
450.9788
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator [coronary]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2D6 [HSA:1565]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Calcium channel blocking drugs
Antiarrhythmic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08D SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
    C08DB Benzothiazepine derivatives
     C08DB01 Diltiazem
      D00616  Diltiazem hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Diltiazem
    D00616  Diltiazem hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00616  Diltiazem hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Diltiazem
      D00616  Diltiazem hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Diltiazem
    D00616  Diltiazem hydrochloride (JP16/USP)
  CYP3A5
   Diltiazem
    D00616  Diltiazem hydrochloride (JP16/USP)
  CYP3A7
   Diltiazem
    D00616  Diltiazem hydrochloride (JP16/USP)
 Inhbitors
  CYP2D6
   Diltiazem
    D00616  Diltiazem hydrochloride (JP16/USP)
  CYP3A4
   Diltiazem
    D00616  Diltiazem hydrochloride (JP16/USP)
  CYP3A5
   Diltiazem
    D00616  Diltiazem hydrochloride (JP16/USP)
  CYP3A7
   Diltiazem
    D00616  Diltiazem hydrochloride (JP16/USP)
  CYP3A
   Diltiazem
    D00616  Diltiazem hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00616  Diltiazem hydrochloride
BRITE hierarchy
Other DBs
CAS: 
33286-22-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C5x C    26.2434  -16.0394
            2   C1y C    25.4013  -14.9298
            3   C1y C    25.7365  -13.5730
            4   S2x S    26.9975  -12.9949
            5   N1y N    27.6492  -16.0646
            6   C8y C    28.2511  -13.6172
            7   C8y C    28.5376  -14.9859
            8   C8x C    29.8688  -15.4230
            9   C8x C    30.9130  -14.4886
            10  C8x C    30.6266  -13.1199
            11  C8x C    29.2952  -12.6828
            12  O5x O    25.5217  -17.2390
            13  C1b C    28.3273  -17.2894
            14  C8y C    24.7294  -12.6046
            15  C8x C    24.7294  -11.2046
            16  C8x C    23.5170  -10.5046
            17  C8y C    22.3045  -11.2046
            18  C8x C    22.3045  -12.6046
            19  C8x C    23.5170  -13.3046
            20  O2a O    21.1094  -10.5143
            21  C1a C    19.9260  -11.1974
            22  O7a O    24.0425  -15.2100
            23  C7a C    23.6044  -16.5300
            24  C1a C    22.2214  -16.8149
            25  O6a O    24.5233  -17.5636
            26  C1b C    29.7498  -17.3149
            27  N1c N    30.4175  -18.5206
            28  C1a C    31.8500  -18.5456
            29  C1a C    29.6920  -19.7271
            30  X   Cl   24.6400  -19.5300
BOND        31
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    6  11 2
            13    1  12 2
            14    5  13 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1
            21    3  14 1 #Down
            22   17  20 1
            23   20  21 1
            24    2  22 1 #Down
            25   22  23 1
            26   23  24 1
            27   23  25 2
            28   13  26 1
            29   26  27 1
            30   27  28 1
            31   27  29 1

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