KEGG   DRUG: Nicardipine hydrochlorideHelp
Entry
D00617                      Drug                                   

Name
Nicardipine hydrochloride (JP17/USAN);
Cardene (TN)
Product
  Generic
NICARDIPINE HYDROCHLORIDE (American Regent), NICARDIPINE HYDROCHLORIDE (AvKARE), NICARDIPINE HYDROCHLORIDE (Avera McKennan Hospital), NICARDIPINE HYDROCHLORIDE (Avera McKennan Hospital), NICARDIPINE HYDROCHLORIDE (Avera McKennan Hospital), NICARDIPINE HYDROCHLORIDE (Carilion Materials Management), NICARDIPINE HYDROCHLORIDE (Carilion Materials Management), NICARDIPINE HYDROCHLORIDE (Emcure Pharmaceuticals), NICARDIPINE HYDROCHLORIDE (Epic Pharma), NICARDIPINE HYDROCHLORIDE (Mylan Institutional LLC), NICARDIPINE HYDROCHLORIDE (Mylan Pharmaceuticals), NICARDIPINE HYDROCHLORIDE (PharmaForce), NICARDIPINE HYDROCHLORIDE (PuraCap Laboratories), NICARDIPINE HYDROCHLORIDE (Sandoz), NICARDIPINE HYDROCHLORIDE (Sandoz), NICARDIPINE HYDROCHLORIDE (Wockhardt Limited), NICARDIPINE HYDROCHLORIDE (Wockhardt USA LLC.)
Formula
C26H29N3O6. HCl
Exact mass
515.1823
Mol weight
515.9859
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Cyp substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antihypertensive, Vasodilator, Calcium channel blocker
  Disease
Hypertension [DS:H01633]
Comment
Dihydropyridine derivative
Target
CACNA1C [HSA:775] [KO:K04850];
CACNA1D [HSA:776] [KO:K04851];
CACNA1F [HSA:778] [KO:K04853];
CACNA1S [HSA:779] [KO:K04857]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA04 Nicardipine
      D00617  Nicardipine hydrochloride (JP17/USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Nicardipine
    D00617  Nicardipine hydrochloride (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00617  Nicardipine hydrochloride (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Nicardipine
      D00617  Nicardipine hydrochloride (JP17/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Nicardipine
    D00617  Nicardipine hydrochloride (JP17/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00617  Nicardipine hydrochloride
  D00617  Nicardipine hydrochloride injection
Cardiovascular agents [br08364.html]
 Antihypertensives
  D00617
BRITE hierarchy
Other DBs
CAS: 
54527-84-3
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        36
            1   C1y C    19.9164  -15.4819
            2   C8y C    19.9164  -16.8638
            3   C2y C    21.1058  -14.7939
            4   C2y C    18.7210  -14.7939
            5   C8x C    21.1175  -17.5519
            6   C8x C    18.7327  -17.5519
            7   C2y C    21.1058  -13.4118
            8   C7a C    22.3071  -15.4819
            9   C2y C    18.7210  -13.4118
            10  C7a C    17.5256  -15.4877
            11  C8y C    21.1234  -18.9280
            12  C8x C    18.7327  -18.9339
            13  N1x N    19.9164  -12.7238
            14  C1a C    22.3071  -12.7238
            15  O7a O    23.5024  -14.7939
            16  O6a O    22.3071  -16.8638
            17  C1a C    17.5256  -12.7238
            18  O7a O    16.3244  -14.7939
            19  O6a O    17.5256  -16.8638
            20  C8x C    19.9280  -19.6220
            21  N2b N    22.3245  -19.6220 #+
            22  C1b C    24.6976  -15.4819
            23  C1a C    15.1290  -15.4877
            24  O3a O    23.8231  -18.6598
            25  O3a O    22.3536  -21.3130 #-
            26  C1b C    25.8989  -14.7880
            27  N1c N    27.0884  -15.4819
            28  C1b C    28.2837  -14.7880
            29  C1a C    27.0943  -16.8638
            30  C8y C    29.4791  -15.4760
            31  C8x C    29.4791  -16.8581
            32  C8x C    30.6804  -14.7880
            33  C8x C    30.6804  -17.5461
            34  C8x C    31.8757  -15.4760
            35  C8x C    31.8757  -16.8581
            36  X   Cl   35.0069  -16.2400
BOND        37
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15    8  16 2
            16    9  17 1
            17   10  18 1
            18   10  19 2
            19   11  20 1
            20   11  21 1
            21   15  22 1
            22   18  23 1
            23   21  24 2
            24   21  25 1
            25   22  26 1
            26   26  27 1
            27   27  28 1
            28   27  29 1
            29   28  30 1
            30   30  31 2
            31   30  32 1
            32   31  33 1
            33   32  34 2
            34   33  35 2
            35    9  13 1
            36   12  20 2
            37   34  35 1

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