KEGG   DRUG: D00617Help
Entry
D00617                      Drug                                   

Name
Nicardipine hydrochloride (JP16/USAN);
Cardene (TN)
Product
  Generic
  Other
Formula
C26H29N3O6. HCl
Exact mass
515.1823
Mol weight
515.9859
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
dihydropyridine calcium channel blocker
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA04 Nicardipine
      D00617  Nicardipine hydrochloride (JP16/USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Nicardipine
    D00617  Nicardipine hydrochloride (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00617  Nicardipine hydrochloride (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Nicardipine
      D00617  Nicardipine hydrochloride (JP16/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Nicardipine
    D00617  Nicardipine hydrochloride (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00617  Nicardipine hydrochloride
  D00617  Nicardipine hydrochloride injection
BRITE hierarchy
Other DBs
CAS: 
54527-84-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        36
            1   C1y C    19.9164  -15.4819
            2   C8y C    19.9164  -16.8638
            3   C2y C    21.1058  -14.7939
            4   C2y C    18.7210  -14.7939
            5   C8x C    21.1175  -17.5519
            6   C8x C    18.7327  -17.5519
            7   C2y C    21.1058  -13.4118
            8   C7a C    22.3071  -15.4819
            9   C2y C    18.7210  -13.4118
            10  C7a C    17.5256  -15.4877
            11  C8y C    21.1234  -18.9280
            12  C8x C    18.7327  -18.9339
            13  N1x N    19.9164  -12.7238
            14  C1a C    22.3071  -12.7238
            15  O7a O    23.5024  -14.7939
            16  O6a O    22.3071  -16.8638
            17  C1a C    17.5256  -12.7238
            18  O7a O    16.3244  -14.7939
            19  O6a O    17.5256  -16.8638
            20  C8x C    19.9280  -19.6220
            21  N2b N    22.3245  -19.6220 #+
            22  C1b C    24.6976  -15.4819
            23  C1a C    15.1290  -15.4877
            24  O3a O    23.8231  -18.6598
            25  O3a O    22.3536  -21.3130 #-
            26  C1b C    25.8989  -14.7880
            27  N1c N    27.0884  -15.4819
            28  C1b C    28.2837  -14.7880
            29  C1a C    27.0943  -16.8638
            30  C8y C    29.4791  -15.4760
            31  C8x C    29.4791  -16.8581
            32  C8x C    30.6804  -14.7880
            33  C8x C    30.6804  -17.5461
            34  C8x C    31.8757  -15.4760
            35  C8x C    31.8757  -16.8581
            36  X   Cl   35.0069  -16.2400
BOND        37
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15    8  16 2
            16    9  17 1
            17   10  18 1
            18   10  19 2
            19   11  20 1
            20   11  21 1
            21   15  22 1
            22   18  23 1
            23   21  24 2
            24   21  25 1
            25   22  26 1
            26   26  27 1
            27   27  28 1
            28   27  29 1
            29   28  30 1
            30   30  31 2
            31   30  32 1
            32   31  33 1
            33   32  34 2
            34   33  35 2
            35    9  13 1
            36   12  20 2
            37   34  35 1

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