KEGG   DRUG: D00619Help
Entry
D00619                      Drug                                   

Name
Verapamil hydrochloride (JP16/USP);
Calan (TN);
Covera-hs (TN);
Vasolan (TN);
Verelan (TN)
Product
  Generic
VERAPAMIL (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions LLC), VERAPAMIL (American Health Packaging), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL (Apotex Corp.), VERAPAMIL HYDROCHLORIDE (Blenheim Pharmacal), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Caraco Pharmaceutical Laboratories), VERAPAMIL HYDROCHLORIDE (Cardinal Health), VERAPAMIL HYDROCHLORIDE (Cardinal Health), VERAPAMIL HYDROCHLORIDE (Cardinal Health), VERAPAMIL HYDROCHLORIDE (Cardinal Health), VERAPAMIL HYDROCHLORIDE (Cardinal Health), VERAPAMIL HYDROCHLORIDE (Carilion Materials Management), VERAPAMIL HYDROCHLORIDE (Clinical Solutions Wholesale), VERAPAMIL HYDROCHLORIDE (Clinical Solutions Wholesale), VERAPAMIL HYDROCHLORIDE (General Injectables & Vaccines), VERAPAMIL HYDROCHLORIDE (General Injectables & Vaccines), VERAPAMIL HYDROCHLORIDE (Glenmark Generics), VERAPAMIL HYDROCHLORIDE (Heritage Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Heritage Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Hospira), VERAPAMIL HYDROCHLORIDE (IVAX Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VERAPAMIL HYDROCHLORIDE (Major Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Mylan Institutional), VERAPAMIL HYDROCHLORIDE (Mylan Institutional), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NCS HealthCare of KY), VERAPAMIL HYDROCHLORIDE (NCS HealthCare of KY), VERAPAMIL HYDROCHLORIDE (Northwind Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Physicians Total Care), VERAPAMIL HYDROCHLORIDE (Physicians Total Care), VERAPAMIL HYDROCHLORIDE (Physicians Total Care), VERAPAMIL HYDROCHLORIDE (Preferred Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Preferred Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (Rebel Distributors Corp), VERAPAMIL HYDROCHLORIDE (Rebel Distributors Corp), VERAPAMIL (St Marys Medical Park Pharmacy), VERAPAMIL HYDROCHLORIDE (St Marys Medical Park Pharmacy), VERAPAMIL (St Marys Medical Park Pharmacy), VERAPAMIL HYDROCHLORIDE (State of Florida DOH Central Pharmacy), VERAPAMIL HYDROCHLORIDE (State of Florida DOH Central Pharmacy), VERAPAMIL HYDROCHLORIDE (Teva Pharmaceuticals USA), VERAPAMIL HYDROCHLORIDE (Unit Dose Services), VERAPAMIL HYDROCHLORIDE (Unit Dose Services), VERAPAMIL (Unit Dose Services), VERAPAMIL HYDROCHLORIDE (Watson Laboratories)
Formula
C27H38N2O4. HCl
Exact mass
490.2598
Mol weight
491.0626
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-anginal;
Cardiac depressant [anti-arrhythmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class IV antiarrhythmic agent
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
potassium inwardly-rectifying channel (KCNJ6) blocker [HSA:3763] [KO:K05000];
voltage-gated potassium channel (KCNA10) blocker [HSA:3744] [KO:K04881];
voltage-gated potassium channel (KCNA3) blocker [HSA:3738] [KO:K04876];
voltage-gated potassium channel (KCNA7) blocker [HSA:3743] [KO:K04880];
voltage-gated potassium channel (KCNC2) blocker [HSA:3747] [KO:K04888]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Transporter: ABCB1 [HSA:5243]
Interaction
CYP inhibition: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Transporter inhibition: ABCB1 [HSA:5243], ABCB4 [HSA:5244], SLC22A3 [HSA:6581]
Drug interaction
Structure map
Calcium channel blocking drugs
Antiarrhythmic drugs
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08D SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
    C08DA Phenylalkylamine derivatives
     C08DA01 Verapamil
      D00619  Verapamil hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00619  Verapamil hydrochloride (JP16/USP)
   217  Vasodilators
    2171  Coronary dilators
     D00619  Verapamil hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Verapamil
      D00619  Verapamil hydrochloride (JP16/USP)
   K+ channel, KCNA, Kv1.x (Shaker)
    voltage-gated potassium channel (KCNA3)
     Verapamil
      D00619  Verapamil hydrochloride (JP16/USP)
    voltage-gated potassium channel (KCNA7)
     Verapamil
      D00619  Verapamil hydrochloride (JP16/USP)
    voltage-gated potassium channel (KCNA10)
     Verapamil
      D00619  Verapamil hydrochloride (JP16/USP)
   K+ channel, KCNC, Kv3.x (Shaw)
    voltage-gated potassium channel (KCNC2)
     Verapamil
      D00619  Verapamil hydrochloride (JP16/USP)
  Related to voltage-gated cation channels
   Inward rectifier channel (Kir)
    potassium inwardly-rectifying channel (KCNJ6)
     Verapamil
      D00619  Verapamil hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
  CYP3A4
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
  CYP3A5
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
  CYP3A7
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
 Inhbitors
  CYP1A2
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
  CYP2D6
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
  CYP3A4
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
  CYP3A5
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
  CYP3A7
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
  CYP3A
   Verapamil
    D00619  Verapamil hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00619  Verapamil hydrochloride
  D00619  Verapamil hydrochloride tablets
BRITE hierarchy
Other DBs
CAS: 
152-11-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        34
            1   C1d C    21.2610  -18.3478
            2   C8y C    20.0604  -19.0472
            3   C1b C    22.4731  -19.0413
            4   C1c C    21.3019  -16.9957
            5   C8x C    18.8483  -18.3478
            6   C8x C    20.0604  -20.4457
            7   C1b C    23.6853  -18.3419
            8   C1a C    22.5142  -16.2848
            9   C1a C    20.0955  -16.2964
            10  C8y C    17.6362  -19.0472
            11  C8x C    18.8483  -21.1509
            12  C1b C    24.8917  -19.0296
            13  C8y C    17.6362  -20.4457
            14  O2a O    16.4183  -18.3478
            15  N1c N    26.1038  -18.3361
            16  O2a O    16.4183  -21.1509
            17  C1a C    15.2061  -19.0472
            18  C1b C    27.3159  -19.0239
            19  C1a C    26.1038  -16.8851
            20  C1a C    15.2061  -20.4515
            21  C1b C    28.5280  -18.3302
            22  C8y C    29.7284  -19.0180
            23  C8x C    30.9407  -18.3185
            24  C8x C    29.7345  -20.4107
            25  C8y C    32.1471  -19.0122
            26  C8x C    30.9464  -21.1101
            27  C8y C    32.1529  -20.4049
            28  O2a O    33.3592  -18.3070
            29  O2a O    33.3708  -21.1042
            30  C1a C    34.5772  -19.0005
            31  C1a C    34.5828  -20.3991
            32  C3b C    21.2610  -19.7452
            33  N3a N    21.2610  -21.1427
            34  X   Cl   31.2200  -23.3100
BOND        34
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12   10  13 2
            13   10  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1
            17   15  18 1
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 2
            25   24  26 1
            26   25  27 1
            27   25  28 1
            28   27  29 1
            29   28  30 1
            30   29  31 1
            31   11  13 1
            32   26  27 2
            33    1  32 1
            34   32  33 3

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