KEGG   DRUG: D00620Help
Entry
D00620                      Drug                                   

Name
Benazepril hydrochloride (JAN/USAN);
Lotensin (TN)
Product
  Generic
BENAZEPRIL (International Labs), BENAZEPRIL HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), BENAZEPRIL HYDROCHLORIDE (American Health Packaging), BENAZEPRIL HYDROCHLORIDE (Amneal Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Apotex Corp), BENAZEPRIL HYDROCHLORIDE (Aurobindo Pharma Limited), BENAZEPRIL HYDROCHLORIDE (AvKARE), BENAZEPRIL HYDROCHLORIDE (AvPAK), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Cardinal Health), BENAZEPRIL HYDROCHLORIDE (Eon Labs), BENAZEPRIL HYDROCHLORIDE (International Labs), BENAZEPRIL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BENAZEPRIL HYDROCHLORIDE (Major Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Mylan Institutional), BENAZEPRIL HYDROCHLORIDE (Mylan Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Northwind Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Physicians Total Care), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (Ranbaxy Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Ranbaxy Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Rebel Distributors Corp.), BENAZEPRIL (STAT RX USA LLC), BENAZEPRIL HYDROCHLORIDE (Solco healthcare U.S.), BENAZEPRIL HYDROCHLORIDE (St Marys Medical Park Pharmacy), BENAZEPRIL HYDROCHLORIDE (St Marys Medical Park Pharmacy), BENAZEPRIL HYDROCHLORIDE (Stat Rx USA), BENAZEPRIL HYDROCHLORIDE (Teva Pharmaceuticals USA), BENAZEPRIL HYDROCHLORIDE (Trigen Laboratories), BENAZEPRIL HYDROCHLORIDE (Unit Dose Services), BENAZEPRIL HYDROCHLORIDE (Unit Dose Services), BENAZEPRIL HYDROCHLORIDE (Unit Dose Services)
Formula
C24H28N2O5. HCl
Exact mass
460.1765
Mol weight
460.9505
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Enzyme inhibitor [angiotensin-converting]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
prodrug, active substance: Benazeprilat [DR:D03077]
Target
angiotensin-converting enzyme (ACE) inhibitor [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system  
 
Interaction
Drug interaction
Structure map
Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA07 Benazepril
      D00620  Benazepril hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Benazepril
    D00620  Benazepril hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00620  Benazepril hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   angiotensin-converting enzyme (ACE)
    Benazepril
     D00620  Benazepril hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
86541-74-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C1x C    23.3231  -19.6615
            2   C8y C    22.4372  -18.5840
            3   C8y C    22.7197  -17.2133
            4   N1y N    23.9591  -16.5857
            5   C1x C    24.7308  -19.7019
            6   C5x C    25.2377  -17.1596
            7   C1y C    25.5777  -18.5180
            8   C8x C    21.6743  -16.2838
            9   C8x C    20.3466  -16.7242
            10  C8x C    20.0641  -18.0949
            11  C8x C    21.1095  -19.0246
            12  C1b C    23.9262  -15.1817
            13  C6a C    25.1248  -14.4519
            14  O6a O    26.3615  -15.1276
            15  O6a O    25.1625  -13.0836
            16  O5x O    26.3330  -16.2423
            17  N1b N    26.9766  -18.5180
            18  C1c C    27.6929  -19.7595
            19  C1b C    29.1069  -19.7602
            20  C7a C    27.0102  -20.9405
            21  C1b C    29.8213  -18.5252
            22  C8y C    31.2056  -18.5264
            23  O6a O    25.6102  -20.9399
            24  O7a O    27.6989  -22.1343
            25  C1b C    29.1070  -22.1349
            26  C1a C    29.7937  -23.3254
            27  C8x C    31.9096  -19.7481
            28  C8x C    33.3085  -19.7492
            29  C8x C    34.0091  -18.5383
            30  C8x C    33.3051  -17.3167
            31  C8x C    31.9062  -17.3155
            32  X   Cl   34.6331  -22.3162
BOND        33
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    4  12 1
            14   12  13 1
            15   13  14 1
            16   13  15 2
            17    6  16 2
            18    7  17 1 #Up
            19   17  18 1
            20   18  19 1 #Up
            21   18  20 1
            22   19  21 1
            23   21  22 1
            24   20  23 2
            25   20  24 1
            26   24  25 1
            27   25  26 1
            28   22  27 2
            29   27  28 1
            30   28  29 2
            31   29  30 1
            32   30  31 2
            33   22  31 1

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