KEGG   DRUG: D00621Help
Entry
D00621                      Drug                                   

Name
Enalapril maleate (JP16/USP);
Renivace (TN);
Vasotec (TN)
Product
  Generic
ENALAPRIL MALEATE (American Health Packaging), ENALAPRIL MALEATE (Apace Packaging), ENALAPRIL MALEATE (Bryant Ranch Prepack), ENALAPRIL MALEATE (Bryant Ranch Prepack), ENALAPRIL MALEATE (Bryant Ranch Prepack), ENALAPRIL MALEATE (Cardinal Health), ENALAPRIL MALEATE (Cardinal Health), ENALAPRIL MALEATE (Contract Pharmacy Services-PA), ENALAPRIL MALEATE (Contract Pharmacy Services-PA), ENALAPRIL MALEATE (Dispensing Solutions), ENALAPRIL MALEATE (Golden State Medical Supply), ENALAPRIL MALEATE (Golden State Medical Supply), ENALAPRIL MALEATE (Lake Erie Medical DBA Quality Care Products LLC), ENALAPRIL MALEATE (Lake Erie Medical DBA Quality Care Products LLC), ENALAPRIL MALEATE (Legacy Pharmaceutical Packaging), ENALAPRIL MALEATE (Major Pharmaceuticals), ENALAPRIL MALEATE (Med Health Pharma), ENALAPRIL MALEATE (Mylan Pharmaceuticals), ENALAPRIL MALEATE (NCS HealthCare of KY), ENALAPRIL MALEATE (PD-Rx Pharmaceuticals), ENALAPRIL MALEATE (PD-Rx Pharmaceuticals), ENALAPRIL MALEATE (PD-Rx Pharmaceuticals), ENALAPRIL MALEATE (Physicians Total Care), ENALAPRIL MALEATE (Preferred Pharmaceuticals), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (REMEDYREPACK), ENALAPRIL MALEATE (Rebel Distributors Corp), ENALAPRIL MALEATE (STAT Rx USA LLC), ENALAPRIL MALEATE (St Marys Medical Park Pharmacy), ENALAPRIL MALEATE (St Marys Medical Park Pharmacy), ENALAPRIL MALEATE (State of Florida DOH Central Pharmacy), ENALAPRIL MALEATE (State of Florida DOH Central Pharmacy), ENALAPRIL MALEATE (State of Florida DOH Central Pharmacy), ENALAPRIL MALEATE (Taro Pharmaceuticals U.S.A.), ENALAPRIL MALEATE (Taro Pharmaceuticals U.S.A.), ENALAPRIL MALEATE (Teva Pharmaceuticals USA), ENALAPRIL MALEATE (UDL Laboratories), ENALAPRIL MALEATE (Unit Dose Services), ENALAPRIL MALEATE (Unit Dose Services), ENALAPRIL MALEATE (Unit Dose Services), ENALAPRIL MALEATE (Unit Dose Services), ENALAPRIL MALEATE (Unit Dose Services), ENALAPRIL MALEATE (Wockhardt Limited), ENALAPRIL MALEATE (Wockhardt USA LLC.)
Formula
C20H28N2O5. C4H4O4
Exact mass
492.2108
Mol weight
492.5189
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
prodrug, active substance: Enalaprilat [DR:D03769]
Target
angiotensin-converting enzyme (ACE) inhibitor [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system  
 
Metabolism
Transporter: SLC15A1 [HSA:6564], SCL15A2 [HSA:6565]
Interaction
Drug interaction
Structure map
Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA02 Enalapril
      D00621  Enalapril maleate (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Enalapril
    D00621  Enalapril maleate (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00621  Enalapril maleate (JP16/USP)
   217  Vasodilators
    2179  Others
     D00621  Enalapril maleate (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   angiotensin-converting enzyme (ACE)
    Enalapril
     D00621  Enalapril maleate (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00621  Enalapril maleate
  D00621  Enalapril maleate tablets
BRITE hierarchy
Other DBs
CAS: 
76095-16-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   N1y N    30.6132  -16.0047
            2   C1x C    30.6011  -14.5972
            3   C5a C    29.4025  -16.7276
            4   C1y C    31.9477  -16.4196
            5   C1x C    31.9318  -14.1523
            6   C1c C    28.1801  -16.0341
            7   O5a O    29.4201  -18.1324
            8   C1x C    32.7630  -15.2776
            9   N1b N    26.9870  -16.7571
            10  C1a C    28.1684  -14.6294
            11  C1c C    25.7645  -16.0576
            12  C1b C    24.5538  -16.7806
            13  C7a C    25.7527  -14.6588
            14  C1b C    23.3372  -16.0871
            15  O7a O    24.5303  -13.9770
            16  O6a O    26.9458  -13.9535
            17  C8y C    22.1264  -16.8099
            18  C8x C    20.8948  -16.1226
            19  C8x C    19.6927  -16.8403
            20  C8x C    19.6432  -18.2401
            21  C8x C    20.9448  -18.9274
            22  C8x C    22.1469  -18.2098
            23  C1b C    23.2951  -14.7129
            24  C1a C    22.0792  -14.0328
            25  C6a C    31.9477  -17.8196
            26  O6a O    30.7012  -18.5388
            27  O6a O    33.1518  -18.5153
            28  C2b C    38.6529  -14.8470
            29  C2b C    37.0191  -14.8528
            30  C6a C    39.3289  -16.0166
            31  C6a C    36.3431  -16.0284
            32  O6a O    38.6589  -17.1920
            33  O6a O    40.6924  -16.0049
            34  O6a O    34.9855  -16.0284
            35  O6a O    37.0308  -17.2038
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 2
            7     4   8 1
            8     6   9 1
            9     6  10 1 #Up
            10    9  11 1
            11   11  12 1
            12   11  13 1 #Up
            13   12  14 1
            14   13  15 1
            15   13  16 2
            16   14  17 1
            17    5   8 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   17  22 1
            24   15  23 1
            25   23  24 1
            26    4  25 1 #Up
            27   25  26 2
            28   25  27 1
            29   28  29 2
            30   28  30 1
            31   29  31 1
            32   30  32 1
            33   30  33 2
            34   31  34 1
            35   31  35 2

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