KEGG   DRUG: D00626Help
Entry
D00626                      Drug                                   

Name
Candesartan cilexetil (JP16/USAN);
Atacand (TN)
Product
  Generic
Formula
C33H34N6O6
Exact mass
610.254
Mol weight
610.6597
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antagonist [angiotensin II receptor];
Antihypertensive
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Prodrug, active substance: Candesartan [DR:D00522]
Target
angiotensin II receptor type 1 (AT1) antagonist [HSA:185] [KO:K04166]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system  
 
Interaction
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA06 Candesartan
      D00626  Candesartan cilexetil (JP16/USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Candesartan
    D00626  Candesartan cilexetil (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00626  Candesartan cilexetil (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Candesartan
      D00626  Candesartan cilexetil (JP16/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Candesartan
    D00626  Candesartan cilexetil (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00626  Candesartan cilexetil
  D00626  Candesartan cilexetil tablets
BRITE hierarchy
Other DBs
CAS: 
145040-37-5
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        45
            1   C8y C    22.5038  -13.1468
            2   N4y N    22.0601  -11.8210
            3   C8y C    23.8997  -13.1525
            4   C8y C    21.8032  -14.3557
            5   C8y C    23.1989  -10.9859
            6   C1b C    20.8336  -11.1319
            7   N5x N    24.3377  -11.8210
            8   C8x C    24.5946  -14.3615
            9   C8x C    22.4981  -15.5646
            10  C7a C    21.0907  -15.5587
            11  O2a O    23.1989   -9.5843
            12  C8y C    19.6306  -11.8561
            13  C8x C    23.8938  -15.5704
            14  O7a O    19.6890  -15.5470
            15  O6a O    21.7739  -16.7735
            16  C1b C    24.4135   -8.8836
            17  C8x C    18.3983  -11.1729
            18  C8x C    19.6597  -13.2343
            19  C1c C    18.9882  -16.7501
            20  C1a C    24.4135   -7.4820
            21  C8x C    17.1953  -11.8971
            22  C8x C    18.4451  -13.9819
            23  O7a O    17.5923  -16.7501
            24  C1a C    19.6773  -17.9590
            25  C8y C    17.2302  -13.2987
            26  C7a C    16.8974  -17.9531
            27  C8y C    16.0215  -14.0170
            28  O7a O    15.5075  -17.9531
            29  O6a O    17.5923  -19.1680
            30  C8y C    14.7892  -13.3395
            31  C8x C    16.0447  -15.4186
            32  C1y C    14.8067  -19.1620
            33  C8y C    14.7658  -11.9321
            34  C8x C    13.5920  -14.0578
            35  C8x C    14.8417  -16.1428
            36  C1x C    13.4167  -19.1620
            37  C1x C    15.5075  -20.3769
            38  N4x N    13.6328  -11.1261
            39  N5x N    15.8987  -11.0853
            40  C8x C    13.6211  -15.4654
            41  C1x C    12.7159  -20.3769
            42  C1x C    14.8126  -21.5858
            43  N5x N    14.0416   -9.7829
            44  N5x N    15.4433   -9.7595
            45  C1x C    13.4167  -21.5858
BOND        50
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    8  13 2
            13   10  14 1
            14   10  15 2
            15   11  16 1
            16   12  17 1
            17   12  18 2
            18   14  19 1
            19   16  20 1
            20   17  21 2
            21   18  22 1
            22   19  23 1
            23   19  24 1
            24   21  25 1
            25   23  26 1
            26   25  27 1
            27   26  28 1
            28   26  29 2
            29   27  30 1
            30   27  31 2
            31   28  32 1
            32   30  33 1
            33   30  34 2
            34   31  35 1
            35   32  36 1
            36   32  37 1
            37   33  38 1
            38   33  39 2
            39   34  40 1
            40   36  41 1
            41   37  42 1
            42   38  43 1
            43   39  44 1
            44   41  45 1
            45    5   7 2
            46    9  13 1
            47   22  25 2
            48   35  40 2
            49   42  45 1
            50   43  44 2

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