KEGG   DRUG: D00627Help
Entry
D00627                      Drug                                   

Name
Telmisartan (JAN/USAN/INN);
Micardis (TN)
Product
  Generic
Formula
C33H30N4O2
Exact mass
514.2369
Mol weight
514.6169
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antagonist [angiotensin II receptor];
Antihypertensive
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
angiotensin II receptor type 1 (AT1) receptor antagonist [HSA:185] [KO:K04166]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system  
 
Metabolism
Enzyme: UGT [KO:K00699]
Transporter: SLCO1B3 [HSA:28234]
Interaction
Transporter inhibition: URAT1 [HSA:116085]
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00627  Telmisartan (JAN/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA07 Telmisartan
      D00627  Telmisartan (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Telmisartan
    D00627  Telmisartan (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor [HSA:185] [KO:K04166]
     Telmisartan [ATC:C09CA07]
      D00627  Telmisartan (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
144701-48-4
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        39
            1   C8x C     6.3000   -7.3500
            2   C8x C     6.3000   -8.7500
            3   C8x C     7.5124   -9.4500
            4   C8x C     8.7249   -8.7500
            5   C8y C     8.7249   -7.3500
            6   C8y C     7.5124   -6.6500
            7   C8y C     9.9560   -6.6390
            8   C8x C    11.1612   -7.3347
            9   C8x C    12.3735   -6.6346
            10  C8y C    12.3735   -5.2346
            11  C8x C    11.1683   -4.5389
            12  C8x C     9.9559   -5.2390
            13  C6a C     7.5124   -5.2502
            14  O6a O     6.2832   -4.5403
            15  O6a O     8.7080   -4.5598
            16  C1b C    13.5914   -4.5312
            17  N4y N    14.8034   -5.2307
            18  C8y C    15.2226   -6.5648
            19  C8y C    16.6225   -6.5780
            20  N5x N    17.0677   -5.2506
            21  C8y C    15.9428   -4.4171
            22  C1b C    15.9551   -3.0100
            23  C1b C    17.1773   -2.3185
            24  C1a C    18.3595   -3.0151
            25  C8x C    14.5112   -7.7706
            26  C8y C    15.1998   -9.0596
            27  C8x C    16.5998   -9.0027
            28  C8y C    17.3111   -7.7969
            29  C1a C    18.6894   -7.7394
            30  C8y C    14.5146  -10.2563
            31  N4y N    13.1146  -10.2563
            32  C1a C    12.4229   -9.0592
            33  C8y C    12.6819  -11.5878
            34  C8y C    13.8146  -12.4107
            35  N5x N    14.9472  -11.5878
            36  C8x C    13.8146  -13.8107
            37  C8x C    12.5931  -14.5162
            38  C8x C    11.3745  -13.8131
            39  C8x C    11.3745  -12.3904
BOND        44
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14    6  13 1
            15   13  14 2
            16   13  15 1
            17   10  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 2
            23   17  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   18  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   19  28 2
            32   28  29 1
            33   26  30 1
            34   30  31 1
            35   31  32 1
            36   31  33 1
            37   33  34 2
            38   34  35 1
            39   30  35 2
            40   34  36 1
            41   36  37 2
            42   37  38 1
            43   38  39 2
            44   39  33 1

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