KEGG   DRUG: D00631Help
Entry
D00631                      Drug                                   

Name
Bepridil hydrochloride hydrate (JAN);
Bepridil hydrochloride (USAN);
Vascor (TN)
Formula
C24H34N2O. HCl. H2O
Exact mass
420.2544
Mol weight
421.0158
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class IV antiarrhythmic agent
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
calcium channel T type blocker [HSA:8911 8912 8913] [KO:K04856 K04855 K04854];
voltage-gated potassium channel (KCNH2) blocker [HSA:3757] [KO:K04905];
voltage-gated potassium channel (KCNQ1) blocker [HSA:3784] [KO:K04926];
voltage-gated potassium channel (KCNA5) blocker [HSA:3741] [KO:K04878];
voltage-gated potassium channel (KCND3) blocker [HSA:3752] [KO:K04893];
potassium inwardly-rectifying channel (KCNJ3) [HSA:3760] [KO:K04997];
potassium inwardly-rectifying channel (KCNJ5) [HSA:3762] [KO:K04999];
potassium inwardly-rectifying channel (KCNJ8) [HSA:3764] [KO:K05001];
potassium inwardly-rectifying channel (KCNJ11) [HSA:3767] [KO:K05004];
potassium inwardly-rectifying channel (KCNJ12) [HSA:3768] [KO:K05005];
sodium channel blocker
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Calcium channel blocking drugs
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08E NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
    C08EA Phenylalkylamine derivatives
     C08EA02 Bepridil
      D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Bepridil
      D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
   K+ channel, KCNA, Kv1.x (Shaker)
    voltage-gated potassium channel (KCNA5)
     Bepridil
      D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
   K+ channel, KCND, Kv4.x (Shal)
    voltage-gated potassium channel (KCND3)
     Bepridil
      D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
   K+ channel, KCNQ, Kv7.x (KQT-like)
    voltage-gated potassium channel (KCNQ1)
     Bepridil
      D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH2)
     Bepridil
      D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
  Related to voltage-gated cation channels
   Inward rectifier channel (Kir)
    potassium inwardly-rectifying channel (KCNJ3)
     Bepridil
      D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
    potassium inwardly-rectifying channel (KCNJ5)
     Bepridil
      D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
    potassium inwardly-rectifying channel (KCNJ11)
     Bepridil
      D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
    potassium inwardly-rectifying channel (KCNJ12)
     Bepridil
      D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Bepridil
    D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
  CYP2D6
   Bepridil
    D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
  CYP3A4
   Bepridil
    D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
 Inhbitors
  CYP2D6
   Bepridil
    D00631  Bepridil hydrochloride hydrate (JAN); Bepridil hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
74764-40-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   N1c N    23.4624  -19.3400
            2   C1b C    24.6731  -20.0358
            3   C1b C    22.2518  -20.0418
            4   C1c C    25.8837  -19.3400
            5   C8y C    21.0411  -19.3400
            6   N1y N    27.1003  -20.0358
            7   C1b C    25.8837  -17.9363
            8   C8x C    19.8305  -20.0418
            9   C8x C    21.0411  -17.9421
            10  C1x C    28.2348  -19.2112
            11  C1x C    27.5330  -21.3693
            12  O2a O    27.0944  -17.2402
            13  C8x C    18.6141  -19.3400
            14  C8x C    19.8305  -17.2402
            15  C1x C    29.3695  -20.0358
            16  C1x C    28.9309  -21.3693
            17  C1b C    28.3108  -17.9363
            18  C8x C    18.6141  -17.9421
            19  C1c C    29.5214  -17.2345
            20  C1a C    30.7321  -17.9363
            21  C1a C    29.5214  -15.8367
            22  C8y C    23.4599  -17.9200
            23  C8x C    24.6637  -17.2222
            24  C8x C    24.6612  -15.8222
            25  C8x C    23.4475  -15.1243
            26  C8x C    22.2437  -15.8222
            27  C8x C    22.2462  -17.2222
            28  O0  O    36.0999  -19.7939
            29  X   Cl   33.2761  -19.7939
BOND        29
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     6  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 2
            14   10  15 1
            15   11  16 1
            16   12  17 1
            17   13  18 2
            18   17  19 1
            19   19  20 1
            20   19  21 1
            21   14  18 1
            22   15  16 1
            23    1  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   22  27 1

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