KEGG   DRUG: Bepridil hydrochlorideHelp
Entry
D00631                      Drug                                   

Name
Bepridil hydrochloride (USAN);
Bepridil hydrochloride hydrate (JAN);
Vascor (TN)
Formula
C24H34N2O. HCl. H2O
Exact mass
420.2544
Mol weight
421.0158
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01807  Phenylalkylamine derivative
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiarrhythmic, Vasodilator, Calcium channel blocker
Comment
Class IV antiarrhythmic agent
Target
calcium channel L type [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
calcium channel T type [HSA:8911 8912 8913] [KO:K04856 K04855 K04854];
voltage-gated potassium channel (KCNH2) [HSA:3757] [KO:K04905];
voltage-gated potassium channel (KCNQ1) [HSA:3784] [KO:K04926];
voltage-gated potassium channel (KCNA5) [HSA:3741] [KO:K04878];
voltage-gated potassium channel (KCND3) [HSA:3752] [KO:K04893];
potassium inwardly-rectifying channel (KCNJ3) [HSA:3760] [KO:K04997];
potassium inwardly-rectifying channel (KCNJ5) [HSA:3762] [KO:K04999];
potassium inwardly-rectifying channel (KCNJ8) [HSA:3764] [KO:K05001];
potassium inwardly-rectifying channel (KCNJ11) [HSA:3767] [KO:K05004];
potassium inwardly-rectifying channel (KCNJ12) [HSA:3768] [KO:K05005];
sodium channel
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Calcium channel blocking drugs
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08E NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
    C08EA Phenylalkylamine derivatives
     C08EA02 Bepridil
      D00631  Bepridil hydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00631  Bepridil hydrochloride (USAN); Bepridil hydrochloride hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Bepridil
      D00631  Bepridil hydrochloride (USAN)
   K+ channel, KCNA, Kv1.x (Shaker)
    voltage-gated potassium channel (KCNA5)
     Bepridil
      D00631  Bepridil hydrochloride (USAN)
   K+ channel, KCND, Kv4.x (Shal)
    voltage-gated potassium channel (KCND3)
     Bepridil
      D00631  Bepridil hydrochloride (USAN)
   K+ channel, KCNQ, Kv7.x (KQT-like)
    voltage-gated potassium channel (KCNQ1)
     Bepridil
      D00631  Bepridil hydrochloride (USAN)
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH2)
     Bepridil
      D00631  Bepridil hydrochloride (USAN)
  Related to voltage-gated cation channels
   Inward rectifier channel (Kir)
    potassium inwardly-rectifying channel (KCNJ3)
     Bepridil
      D00631  Bepridil hydrochloride (USAN)
    potassium inwardly-rectifying channel (KCNJ5)
     Bepridil
      D00631  Bepridil hydrochloride (USAN)
    potassium inwardly-rectifying channel (KCNJ11)
     Bepridil
      D00631  Bepridil hydrochloride (USAN)
    potassium inwardly-rectifying channel (KCNJ12)
     Bepridil
      D00631  Bepridil hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Bepridil
    D00631  Bepridil hydrochloride (USAN)
 CYP substrates
  CYP2C9
   Bepridil
    D00631  Bepridil hydrochloride (USAN)
  CYP2D6
   Bepridil
    D00631  Bepridil hydrochloride (USAN)
  CYP3A4
   Bepridil
    D00631  Bepridil hydrochloride (USAN)
Cardiovascular agents [br08364.html]
 Antiarrhythmics
  D00631
BRITE hierarchy
Other DBs
CAS: 
74764-40-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   N1c N    23.4624  -19.3400
            2   C1b C    24.6731  -20.0358
            3   C1b C    22.2518  -20.0418
            4   C1c C    25.8837  -19.3400
            5   C8y C    21.0411  -19.3400
            6   N1y N    27.1003  -20.0358
            7   C1b C    25.8837  -17.9363
            8   C8x C    19.8305  -20.0418
            9   C8x C    21.0411  -17.9421
            10  C1x C    28.2348  -19.2112
            11  C1x C    27.5330  -21.3693
            12  O2a O    27.0944  -17.2402
            13  C8x C    18.6141  -19.3400
            14  C8x C    19.8305  -17.2402
            15  C1x C    29.3695  -20.0358
            16  C1x C    28.9309  -21.3693
            17  C1b C    28.3108  -17.9363
            18  C8x C    18.6141  -17.9421
            19  C1c C    29.5214  -17.2345
            20  C1a C    30.7321  -17.9363
            21  C1a C    29.5214  -15.8367
            22  C8y C    23.4599  -17.9200
            23  C8x C    24.6637  -17.2222
            24  C8x C    24.6612  -15.8222
            25  C8x C    23.4475  -15.1243
            26  C8x C    22.2437  -15.8222
            27  C8x C    22.2462  -17.2222
            28  O0  O    36.0999  -19.7939
            29  X   Cl   33.2761  -19.7939
BOND        29
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     6  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 2
            14   10  15 1
            15   11  16 1
            16   12  17 1
            17   13  18 2
            18   17  19 1
            19   19  20 1
            20   19  21 1
            21   14  18 1
            22   15  16 1
            23    1  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   22  27 1

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