KEGG   DRUG: D00632Help
Entry
D00632                      Drug                                   

Name
Dobutamine hydrochloride (JP16/USP);
Dobutrex (TN)
Product
  Generic
Formula
C18H23NO3. HCl
Exact mass
337.1445
Mol weight
337.8411
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiotonic
Remark
Therapeutic category: 
ATC code: 
Target
beta1-adrenergic receptor agonist [HSA:153] [KO:K04141]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D00632  Dobutamine hydrochloride (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA07 Dobutamine
      D00632  Dobutamine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor [HSA:153] [KO:K04141]
     Dobutamine [ATC:C01CA07]
      D00632  Dobutamine hydrochloride (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
49745-95-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    33.0803  -15.7788
            2   C8x C    34.2973  -15.0858
            3   C8x C    33.1444  -17.1820
            4   C1b C    31.8691  -15.0800
            5   C8y C    35.5083  -15.7904
            6   C8x C    34.2856  -17.8866
            7   C1b C    30.6522  -15.7788
            8   C8y C    35.5026  -17.1879
            9   O1a O    36.7252  -15.0974
            10  N1b N    29.4411  -15.0858
            11  O1a O    36.7136  -17.8923
            12  C1c C    28.2359  -15.7845
            13  C1b C    27.0189  -15.0858
            14  C1a C    28.2359  -17.1820
            15  C1b C    25.8079  -15.7845
            16  C8y C    24.5909  -15.0858
            17  C8x C    23.3856  -15.7845
            18  C8x C    24.5909  -13.6883
            19  C8x C    22.1687  -15.0858
            20  C8x C    23.3856  -12.9839
            21  C8y C    22.1687  -13.6883
            22  O1a O    20.9518  -12.9839
            23  X   Cl   24.4937  -18.2392
BOND        23
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    8  11 1
            11   10  12 1
            12   12  13 1
            13   12  14 1
            14   13  15 1
            15   15  16 1
            16   16  17 2
            17   16  18 1
            18   17  19 1
            19   18  20 2
            20   19  21 2
            21   21  22 1
            22    6   8 1
            23   20  21 1

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