KEGG   DRUG: Dobutamine hydrochlorideHelp
Entry
D00632                      Drug                                   

Name
Dobutamine hydrochloride (JP17/USP);
Dobutrex (TN)
Product
  Generic
Formula
C18H23NO3. HCl
Exact mass
337.1445
Mol weight
337.8411
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
Unclassified
 DG01951  Catecholamine adrenergic receptor agonist
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Cardiotonic, beta1-Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
beta1-adrenergic receptor [HSA:153] [KO:K04141]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Salivary secretion
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA07 Dobutamine
      D00632  Dobutamine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D00632  Dobutamine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Dobutamine
      D00632  Dobutamine hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00632  Dobutamine hydrochloride
BRITE hierarchy
Other DBs
CAS: 
49745-95-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    14.3500  -16.3800
            2   C8x C    13.1600  -15.6800
            3   C8x C    14.3500  -17.7800
            4   C1b C    15.6100  -15.6800
            5   C8y C    11.9700  -16.3800
            6   C8x C    13.1600  -18.4800
            7   C1b C    16.8000  -16.3800
            8   C8y C    11.9700  -17.7800
            9   O1a O    10.7100  -15.6800
            10  N1b N    18.0600  -15.6800
            11  O1a O    10.7800  -18.4800
            12  C1c C    19.2500  -16.3800
            13  C1b C    20.4400  -15.6800
            14  C1a C    19.2500  -17.7800
            15  C1b C    21.7000  -16.3800
            16  C8y C    22.8900  -15.6800
            17  C8x C    24.0800  -16.3800
            18  C8x C    22.8900  -14.2800
            19  C8x C    25.3400  -15.6800
            20  C8x C    24.0800  -13.5800
            21  C8y C    25.3400  -14.2800
            22  O1a O    26.5300  -13.5800
            23  X   Cl   26.0400  -18.4800
BOND        23
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    8  11 1
            11   10  12 1
            12   12  13 1
            13   12  14 1
            14   13  15 1
            15   15  16 1
            16   16  17 2
            17   16  18 1
            18   17  19 1
            19   18  20 2
            20   19  21 2
            21   21  22 1
            22    6   8 1
            23   20  21 1

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