KEGG   DRUG: Dopamine hydrochlorideHelp
Entry
D00633                      Drug                                   

Name
Dopamine hydrochloride (JP17/USP);
Actopamin (TN);
Intropin (TN)
Product
  Generic
Formula
C8H11NO2. HCl
Exact mass
189.0557
Mol weight
189.6394
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01592  COMT substrate
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01467  Dopamine D1-receptor agonist
  DG01468  Dopamine D2-receptor agonist
  DG01469  Dopamine D3-receptor agonist
  DG01470  Dopamine D4-receptor agonist
  DG01471  Dopamine D5-receptor agonist
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Cardiotonic, Dopamine receptor agonist
Comment
Catecholamine derivative
Target
DRD1 [HSA:1812] [KO:K04144];
DRD2 [HSA:1813] [KO:K04145];
DRD3 [HSA:1814] [KO:K04146];
DRD4 [HSA:1815] [KO:K04147];
DRD5 [HSA:1816] [KO:K05840]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Metabolism
Enzyme: MAOB [HSA:4129], COMT [HSA:1312]
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA04 Dopamine
      D00633  Dopamine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D00633  Dopamine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D1-receptor
     Dopamine
      D00633  Dopamine hydrochloride (JP17/USP)
    dopamine D2-receptor
     Dopamine
      D00633  Dopamine hydrochloride (JP17/USP)
    dopamine D3-receptor
     Dopamine
      D00633  Dopamine hydrochloride (JP17/USP)
    dopamine D4-receptor
     Dopamine
      D00633  Dopamine hydrochloride (JP17/USP)
    dopamine D5-receptor
     Dopamine
      D00633  Dopamine hydrochloride (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  SLC22A2
   Dopamine
    D00633  Dopamine hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00633  Dopamine hydrochloride
  D00633  Dopamine hydrochloride injection
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tyrosine
   Isoquinoline alkaloids
    D00633  Dopamine hydrochloride (JP15/USP)
BRITE hierarchy
Other DBs
CAS: 
62-31-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        12
            1   C8y C    28.7000  -14.7000
            2   C8x C    27.5100  -14.0000
            3   C8x C    28.7000  -16.1000
            4   C1b C    29.8900  -14.0000
            5   C8y C    26.3200  -14.7000
            6   C8x C    27.5100  -16.8000
            7   C1b C    31.1500  -14.7000
            8   C8y C    26.3200  -16.1000
            9   O1a O    25.0600  -14.0000
            10  N1a N    32.3400  -14.0000
            11  O1a O    25.0600  -16.8000
            12  X   Cl   32.5500  -16.8000
BOND        11
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     5   9 1
            9     7  10 1
            10    8  11 1
            11    6   8 2

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