KEGG   DRUG: D00634Help
Entry
D00634                      Drug                                   

Name
Bisoprolol fumarate (JP16/USP);
Zebeta (TN)
Product
  Generic
Formula
(C18H31NO4)2. C4H4O4
Exact mass
766.4616
Mol weight
766.9582
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive [beta-blocker]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB07 Bisoprolol
      D00634  Bisoprolol fumarate (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Bisoprolol
    D00634  Bisoprolol fumarate (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00634  Bisoprolol fumarate (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Bisoprolol
      D00634  Bisoprolol fumarate (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00634  Bisoprolol fumarate
  D00634  Bisoprolol fumarate tablets
BRITE hierarchy
Other DBs
CAS: 
104344-23-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        54
            1   C2b C    24.3463   -9.3353
            2   C2b C    25.5331   -8.6372
            3   C6a C    23.1595   -8.7070
            4   C6a C    26.7896   -9.3353
            5   O6a O    21.9030   -9.4051
            6   O6a O    23.1595   -7.2410
            7   O6a O    27.9764   -8.6372
            8   O6a O    26.7896  -10.7315
            9   C8y C    11.2700   -7.3500
            10  C8x C    12.5300   -8.0500
            11  C8x C    10.0800   -8.0500
            12  O2a O    11.2700   -5.9500
            13  C8x C    12.5300   -9.4500
            14  C8x C    10.0800   -9.4500
            15  C1b C    12.5300   -5.3200
            16  C8y C    11.2700  -10.1500
            17  C1c C    13.7200   -5.9500
            18  C1b C    11.2700  -11.5500
            19  C1b C    14.9100   -5.3200
            20  O1a O    13.7200   -7.3500
            21  O2a O    10.0800  -12.2500
            22  N1b N    16.1700   -5.9500
            23  C1b C     8.8900  -11.5500
            24  C1c C    17.3600   -5.3200
            25  C1b C     7.7000  -12.2500
            26  C1a C    18.5500   -5.9500
            27  C1a C    17.3600   -3.9200
            28  O2a O     6.5100  -11.5500
            29  C1c C     5.3200  -12.2500
            30  C1a C     4.0600  -11.5500
            31  C1a C     5.3200  -13.6500
            32  C8y C    11.2700   -7.3500
            33  C8x C    12.5300   -8.0500
            34  C8x C    12.5300   -9.4500
            35  C8y C    11.2700  -10.1500
            36  C1b C    11.2700  -11.5500
            37  O2a O    10.0800  -12.2500
            38  C1b C     8.8900  -11.5500
            39  C1b C     7.7000  -12.2500
            40  O2a O     6.5100  -11.5500
            41  C1c C     5.3200  -12.2500
            42  C1a C     4.0600  -11.5500
            43  C1a C     5.3200  -13.6500
            44  C8x C    10.0800   -9.4500
            45  C8x C    10.0800   -8.0500
            46  O2a O    11.2700   -5.9500
            47  C1b C    12.5300   -5.3200
            48  C1c C    13.7200   -5.9500
            49  C1b C    14.9100   -5.3200
            50  N1b N    16.1700   -5.9500
            51  C1c C    17.3600   -5.3200
            52  C1a C    18.5500   -5.9500
            53  C1a C    17.3600   -3.9200
            54  O1a O    13.7200   -7.3500
BOND        53
            1     1   2 2
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     9  10 1
            9     9  11 2
            10    9  12 1
            11   10  13 2
            12   11  14 1
            13   12  15 1
            14   13  16 1
            15   15  17 1
            16   16  18 1
            17   17  19 1
            18   17  20 1
            19   18  21 1
            20   19  22 1
            21   21  23 1
            22   22  24 1
            23   23  25 1
            24   24  26 1
            25   24  27 1
            26   25  28 1
            27   28  29 1
            28   29  30 1
            29   29  31 1
            30   14  16 2
            31   32  33 1
            32   32  45 2
            33   32  46 1
            34   33  34 2
            35   45  44 1
            36   46  47 1
            37   34  35 1
            38   47  48 1
            39   35  36 1
            40   48  49 1
            41   48  54 1
            42   36  37 1
            43   49  50 1
            44   37  38 1
            45   50  51 1
            46   38  39 1
            47   51  52 1
            48   51  53 1
            49   39  40 1
            50   40  41 1
            51   41  42 1
            52   41  43 1
            53   44  35 2
BRACKET     1     2.5900  -14.3500    2.5900   -3.3600
            1    19.8800   -3.3600   19.8800  -14.3500
            1  2
 ORIGINAL  1    9  10  13  16  18  21  23  25  28  29  30  31  14  11  12  15
            1   17  19  22  24  26  27  20
 REPEAT    1   32  33  34  35  36  37  38  39  40  41  42  43  44  45  46  47
            1   48  49  50  51  52  53  54

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