KEGG   DRUG: Bisoprolol fumarateHelp
Entry
D00634                      Drug                                   

Name
Bisoprolol fumarate (JP17/USP);
Zebeta (TN)
Product
  Generic
Formula
(C18H31NO4)2. C4H4O4
Exact mass
766.4616
Mol weight
766.9582
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antihypertensive [beta-blocker]
Target
beta1-adrenergic receptor [HSA:153] [KO:K04141]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Salivary secretion
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB07 Bisoprolol
      D00634  Bisoprolol fumarate (JP17/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Bisoprolol
    D00634  Bisoprolol fumarate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00634  Bisoprolol fumarate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Bisoprolol
      D00634  Bisoprolol fumarate (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00634  Bisoprolol fumarate
  D00634  Bisoprolol fumarate tablets
Cardiovascular agents [br08364.html]
 Antihypertensives
  D00634
BRITE hierarchy
Other DBs
CAS: 
104344-23-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        54
            1   C2b C    24.3463   -9.3353
            2   C2b C    25.5331   -8.6372
            3   C6a C    23.1595   -8.7070
            4   C6a C    26.7896   -9.3353
            5   O6a O    21.9030   -9.4051
            6   O6a O    23.1595   -7.2410
            7   O6a O    27.9764   -8.6372
            8   O6a O    26.7896  -10.7315
            9   C8y C    11.2700   -7.3500
            10  C8x C    12.5300   -8.0500
            11  C8x C    10.0800   -8.0500
            12  O2a O    11.2700   -5.9500
            13  C8x C    12.5300   -9.4500
            14  C8x C    10.0800   -9.4500
            15  C1b C    12.5300   -5.3200
            16  C8y C    11.2700  -10.1500
            17  C1c C    13.7200   -5.9500
            18  C1b C    11.2700  -11.5500
            19  C1b C    14.9100   -5.3200
            20  O1a O    13.7200   -7.3500
            21  O2a O    10.0800  -12.2500
            22  N1b N    16.1700   -5.9500
            23  C1b C     8.8900  -11.5500
            24  C1c C    17.3600   -5.3200
            25  C1b C     7.7000  -12.2500
            26  C1a C    18.5500   -5.9500
            27  C1a C    17.3600   -3.9200
            28  O2a O     6.5100  -11.5500
            29  C1c C     5.3200  -12.2500
            30  C1a C     4.0600  -11.5500
            31  C1a C     5.3200  -13.6500
            32  C8y C    11.2700   -7.3500
            33  C8x C    12.5300   -8.0500
            34  C8x C    12.5300   -9.4500
            35  C8y C    11.2700  -10.1500
            36  C1b C    11.2700  -11.5500
            37  O2a O    10.0800  -12.2500
            38  C1b C     8.8900  -11.5500
            39  C1b C     7.7000  -12.2500
            40  O2a O     6.5100  -11.5500
            41  C1c C     5.3200  -12.2500
            42  C1a C     4.0600  -11.5500
            43  C1a C     5.3200  -13.6500
            44  C8x C    10.0800   -9.4500
            45  C8x C    10.0800   -8.0500
            46  O2a O    11.2700   -5.9500
            47  C1b C    12.5300   -5.3200
            48  C1c C    13.7200   -5.9500
            49  C1b C    14.9100   -5.3200
            50  N1b N    16.1700   -5.9500
            51  C1c C    17.3600   -5.3200
            52  C1a C    18.5500   -5.9500
            53  C1a C    17.3600   -3.9200
            54  O1a O    13.7200   -7.3500
BOND        53
            1     1   2 2
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     9  10 1
            9     9  11 2
            10    9  12 1
            11   10  13 2
            12   11  14 1
            13   12  15 1
            14   13  16 1
            15   15  17 1
            16   16  18 1
            17   17  19 1
            18   17  20 1
            19   18  21 1
            20   19  22 1
            21   21  23 1
            22   22  24 1
            23   23  25 1
            24   24  26 1
            25   24  27 1
            26   25  28 1
            27   28  29 1
            28   29  30 1
            29   29  31 1
            30   14  16 2
            31   32  33 1
            32   32  45 2
            33   32  46 1
            34   33  34 2
            35   45  44 1
            36   46  47 1
            37   34  35 1
            38   47  48 1
            39   35  36 1
            40   48  49 1
            41   48  54 1
            42   36  37 1
            43   49  50 1
            44   37  38 1
            45   50  51 1
            46   38  39 1
            47   51  52 1
            48   51  53 1
            49   39  40 1
            50   40  41 1
            51   41  42 1
            52   41  43 1
            53   44  35 2
BRACKET     1     2.5900  -14.3500    2.5900   -3.3600
            1    19.8800   -3.3600   19.8800  -14.3500
            1  2
 ORIGINAL  1    9  10  13  16  18  21  23  25  28  29  30  31  14  11  12  15
            1   17  19  22  24  26  27  20
 REPEAT    1   32  33  34  35  36  37  38  39  40  41  42  43  44  45  46  47
            1   48  49  50  51  52  53  54

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