KEGG   DRUG: D00637Help
Entry
D00637                      Drug                                   

Name
Disopyramide phosphate (JAN/USP);
Norpace (TN)
Product
  Generic
Formula
C21H29N3O. H3PO4
Exact mass
437.208
Mol weight
437.4696
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic] [DS:H00292]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: SLC22A3 [HSA:6581]
Interaction
Transporter inhibition: SLC22A1 [HSA:6580]
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA03 Disopyramide
      D00637  Disopyramide phosphate (JAN/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Disopyramide
    D00637  Disopyramide phosphate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00637  Disopyramide phosphate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Disopyramide
      D00637  Disopyramide phosphate (JAN/USP)
    voltage-gated sodium channel (SCN2A)
     Disopyramide
      D00637  Disopyramide phosphate (JAN/USP)
    voltage-gated sodium channel (SCN3A)
     Disopyramide
      D00637  Disopyramide phosphate (JAN/USP)
    voltage-gated sodium channel (SCN4A)
     Disopyramide
      D00637  Disopyramide phosphate (JAN/USP)
    voltage-gated sodium channel (SCN5A)
     Disopyramide
      D00637  Disopyramide phosphate (JAN/USP)
    voltage-gated sodium channel (SCN8A)
     Disopyramide
      D00637  Disopyramide phosphate (JAN/USP)
    voltage-gated sodium channel (SCN9A)
     Disopyramide
      D00637  Disopyramide phosphate (JAN/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Disopyramide
    D00637  Disopyramide phosphate (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
22059-60-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   P1b P    35.9712  -15.3016
            2   O1c O    37.3683  -15.3074
            3   O1c O    35.9655  -16.6987
            4   O1c O    34.5741  -15.3016
            5   O1c O    35.9655  -13.8986
            6   C8x C    25.2790  -16.8457
            7   C8x C    25.2790  -18.2076
            8   C8x C    26.4584  -18.8885
            9   N5x N    27.6379  -18.2076
            10  C8y C    27.6379  -16.8457
            11  C8x C    26.4584  -16.1647
            12  C8x C    29.9967  -18.2076
            13  C8y C    29.9967  -16.8457
            14  C1d C    28.8173  -16.1647
            15  C8x C    31.1762  -18.8885
            16  C8x C    32.3556  -18.2076
            17  C8x C    32.3556  -16.8457
            18  C8x C    31.1762  -16.1647
            19  C1b C    28.8173  -14.8028
            20  C1b C    29.9988  -14.1207
            21  C5a C    26.8208  -15.0752
            22  N1a N    26.8208  -13.7133
            23  O5a O    25.6650  -15.7548
            24  N1c N    29.9988  -12.6240
            25  C1c C    31.1623  -11.9521
            26  C1c C    28.8034  -11.9337
            27  C1a C    27.6325  -12.6097
            28  C1a C    28.8036  -10.5810
            29  C1a C    32.3174  -12.6190
            30  C1a C    31.1624  -10.5812
BOND        30
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 2
            5     6   7 2
            6     7   8 1
            7     8   9 2
            8     9  10 1
            9    10  11 2
            10    6  11 1
            11   12  13 1
            12   13  14 1
            13   10  14 1
            14   12  15 2
            15   15  16 1
            16   16  17 2
            17   17  18 1
            18   13  18 2
            19   14  19 1
            20   19  20 1
            21   14  21 1
            22   21  22 1
            23   21  23 2
            24   20  24 1
            25   24  25 1
            26   24  26 1
            27   26  27 1
            28   26  28 1
            29   25  29 1
            30   25  30 1

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