KEGG   DRUG: Flecainide acetateHelp
Entry
D00638                      Drug                                   

Name
Flecainide acetate (JP17/USP);
Tambocor (TN)
Product
  Generic
FLECAINIDE ACETATE (Ranbaxy Pharmaceuticals), FLECAINIDE ACETATE (A-S Medication Solutions), FLECAINIDE ACETATE (A-S Medication Solutions), FLECAINIDE ACETATE (A-S Medication Solutions), FLECAINIDE ACETATE (A-S Medication Solutions), FLECAINIDE ACETATE (American Health Packaging), FLECAINIDE ACETATE (Amneal Pharmaceuticals LLC), FLECAINIDE ACETATE (Apotex Corp.), FLECAINIDE ACETATE (Aurobindo Pharma Limited), FLECAINIDE ACETATE (AvKARE), FLECAINIDE ACETATE (AvPAK), FLECAINIDE ACETATE (Avera McKennan Hospital), FLECAINIDE ACETATE (Avera McKennan Hospital), FLECAINIDE ACETATE (Barr Laboratories), FLECAINIDE ACETATE (Carilion Materials Management), FLECAINIDE ACETATE (Citron Pharma LLC), FLECAINIDE ACETATE (KAISER FOUNDATION HOSPITALS), FLECAINIDE ACETATE (Physicians Total Care), FLECAINIDE ACETATE (West-Ward Pharmaceuticals Corp.), FLECAINIDE ACETATE (ANI Pharmaceuticals)
Formula
C17H20F6N2O3. C2H4O2
Exact mass
474.1589
Mol weight
474.3947
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiarrhythmic, Sodium channel blocker
Comment
Class I antiarrhythmic agent (Ic)
Target
SCN1A [HSA:6323] [KO:K04833] ;
SCN2A [HSA:6326] [KO:K04834] ;
SCN3A [HSA:6328] [KO:K04836] ;
SCN4A [HSA:6329] [KO:K04837] ;
SCN5A [HSA:6331] [KO:K04838] ;
SCN8A [HSA:6334] [KO:K04840] ;
SCN9A [HSA:6335] [KO:K04841];
SCN10A [HSA:6336] [KO:K04842]
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC04 Flecainide
      D00638  Flecainide acetate (JP17/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Flecainide
    D00638  Flecainide acetate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00638  Flecainide acetate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Flecainide
      D00638  Flecainide acetate (JP17/USP)
    voltage-gated sodium channel (SCN2A)
     Flecainide
      D00638  Flecainide acetate (JP17/USP)
    voltage-gated sodium channel (SCN3A)
     Flecainide
      D00638  Flecainide acetate (JP17/USP)
    voltage-gated sodium channel (SCN4A)
     Flecainide
      D00638  Flecainide acetate (JP17/USP)
    voltage-gated sodium channel (SCN5A)
     Flecainide
      D00638  Flecainide acetate (JP17/USP)
    voltage-gated sodium channel (SCN8A)
     Flecainide
      D00638  Flecainide acetate (JP17/USP)
    voltage-gated sodium channel (SCN9A)
     Flecainide
      D00638  Flecainide acetate (JP17/USP)
   K+ channel, KCND, Kv4.x (Shal)
    voltage-gated potassium channel (KCND3)
     Flecainide
      D00638  Flecainide acetate (JP17/USP)
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH6)
     Flecainide
      D00638  Flecainide acetate (JP17/USP)
    voltage-gated potassium channel (KCNH7)
     Flecainide
      D00638  Flecainide acetate (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Flecainide
    D00638  Flecainide acetate (JP17/USP)
  CYP3A4
   Flecainide
    D00638  Flecainide acetate (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00638  Flecainide acetate
  D00638  Flecainide acetate
Cardiovascular agents [br08364.html]
 Antiarrhythmics
  D00638
BRITE hierarchy
Other DBs
CAS: 
54143-56-5
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C1x C     3.7100  -14.3500
            2   C1x C     3.7100  -15.7500
            3   N1x N     4.9224  -16.4500
            4   C1y C     6.1349  -15.7500
            5   C1x C     6.1349  -14.3500
            6   C1x C     4.9224  -13.6500
            7   C1b C     7.3660  -16.4610
            8   N1b N     8.5712  -15.7653
            9   C5a C     9.7535  -16.4481
            10  C8y C    10.9475  -15.7588
            11  O5a O     9.7535  -17.8498
            12  C8y C    12.1354  -16.4448
            13  C8x C    13.3479  -15.7449
            14  C8x C    13.3480  -14.3449
            15  C8y C    12.1601  -13.6589
            16  C8x C    10.9476  -14.3588
            17  O2a O    12.1601  -12.2501
            18  C1b C    13.3874  -11.5414
            19  C1d C    14.5904  -12.2360
            20  X   F    15.8028  -12.9360
            21  X   F    13.8771  -13.4722
            22  X   F    15.2764  -11.0472
            23  O2a O    12.1354  -17.8498
            24  C1b C    13.3288  -18.5389
            25  C1d C    14.5148  -17.8542
            26  X   F    15.7273  -17.1542
            27  X   F    15.2066  -19.0527
            28  X   F    13.8071  -16.6279
            29  C6a C    19.2500  -15.3300
            30  C1a C    20.4639  -16.0327
            31  O6a O    18.0419  -16.0327
            32  O6a O    19.2500  -13.9303
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12   10  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   10  16 1
            18   15  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 1
            23   19  22 1
            24   12  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   25  27 1
            29   25  28 1
            30   29  30 1
            31   29  31 1
            32   29  32 2

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