KEGG   DRUG: D00638Help
Entry
D00638                      Drug                                   

Name
Flecainide acetate (JP16/USP);
Tambocor (TN)
Product
  Generic
Formula
C17H20F6N2O3. C2H4O2
Exact mass
474.1589
Mol weight
474.3947
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent (Ic)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
voltage-gated potassium channel (KCNH2) blocker [HSA:3757] [KO:K04905];
voltage-gated potassium channel (KCNH6) blocker [HSA:81033] [KO:K04909];
voltage-gated potassium channel (KCNH7) blocker [HSA:90134] [KO:K04910];
voltage-gated potassium channel (KCND3) blocker [HSA:3752] [KO:K04893]
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC04 Flecainide
      D00638  Flecainide acetate (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Flecainide
    D00638  Flecainide acetate (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00638  Flecainide acetate (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Flecainide
      D00638  Flecainide acetate (JP16/USP)
    voltage-gated sodium channel (SCN2A)
     Flecainide
      D00638  Flecainide acetate (JP16/USP)
    voltage-gated sodium channel (SCN3A)
     Flecainide
      D00638  Flecainide acetate (JP16/USP)
    voltage-gated sodium channel (SCN4A)
     Flecainide
      D00638  Flecainide acetate (JP16/USP)
    voltage-gated sodium channel (SCN5A)
     Flecainide
      D00638  Flecainide acetate (JP16/USP)
    voltage-gated sodium channel (SCN8A)
     Flecainide
      D00638  Flecainide acetate (JP16/USP)
    voltage-gated sodium channel (SCN9A)
     Flecainide
      D00638  Flecainide acetate (JP16/USP)
   K+ channel, KCND, Kv4.x (Shal)
    voltage-gated potassium channel (KCND3)
     Flecainide
      D00638  Flecainide acetate (JP16/USP)
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH6)
     Flecainide
      D00638  Flecainide acetate (JP16/USP)
    voltage-gated potassium channel (KCNH7)
     Flecainide
      D00638  Flecainide acetate (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Flecainide
    D00638  Flecainide acetate (JP16/USP)
  CYP3A4
   Flecainide
    D00638  Flecainide acetate (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00638  Flecainide acetate
  D00638  Flecainide acetate
BRITE hierarchy
Other DBs
CAS: 
54143-56-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C1x C     3.7100  -14.3500
            2   C1x C     3.7100  -15.7500
            3   N1x N     4.9224  -16.4500
            4   C1y C     6.1349  -15.7500
            5   C1x C     6.1349  -14.3500
            6   C1x C     4.9224  -13.6500
            7   C1b C     7.3660  -16.4610
            8   N1b N     8.5712  -15.7653
            9   C5a C     9.7535  -16.4481
            10  C8y C    10.9475  -15.7588
            11  O5a O     9.7535  -17.8498
            12  C8y C    12.1354  -16.4448
            13  C8x C    13.3479  -15.7449
            14  C8x C    13.3480  -14.3449
            15  C8y C    12.1601  -13.6589
            16  C8x C    10.9476  -14.3588
            17  O2a O    12.1601  -12.2501
            18  C1b C    13.3874  -11.5414
            19  C1d C    14.5904  -12.2360
            20  X   F    15.8028  -12.9360
            21  X   F    13.8771  -13.4722
            22  X   F    15.2764  -11.0472
            23  O2a O    12.1354  -17.8498
            24  C1b C    13.3288  -18.5389
            25  C1d C    14.5148  -17.8542
            26  X   F    15.7273  -17.1542
            27  X   F    15.2066  -19.0527
            28  X   F    13.8071  -16.6279
            29  C6a C    19.2500  -15.3300
            30  C1a C    20.4639  -16.0327
            31  O6a O    18.0419  -16.0327
            32  O6a O    19.2500  -13.9303
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12   10  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   10  16 1
            18   15  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 1
            23   19  22 1
            24   12  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   25  27 1
            29   25  28 1
            30   29  30 1
            31   29  31 1
            32   29  32 2

» Japanese version   » Back

DBGET integrated database retrieval system