KEGG   DRUG: D00639Help
Entry
D00639                      Drug                                   

Name
Mexiletine hydrochloride (JP16/USP);
Mexitil (TN)
Product
  Generic
Formula
C11H17NO. HCl
Exact mass
215.1077
Mol weight
215.7197
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent (Ib)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB02 Mexiletine
      D00639  Mexiletine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Mexiletine
    D00639  Mexiletine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  19  Other agents affecting nervous system and sensory organs
   190  Other agents affecting nervous system and sensory organs
    1900  Other agents affecting nervous system and sensory organs
     D00639  Mexiletine hydrochloride (JP16/USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00639  Mexiletine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Mexiletine
      D00639  Mexiletine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN2A)
     Mexiletine
      D00639  Mexiletine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN3A)
     Mexiletine
      D00639  Mexiletine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN4A)
     Mexiletine
      D00639  Mexiletine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN5A)
     Mexiletine
      D00639  Mexiletine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN8A)
     Mexiletine
      D00639  Mexiletine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN9A)
     Mexiletine
      D00639  Mexiletine hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Mexiletine
    D00639  Mexiletine hydrochloride (JP16/USP)
  CYP2D6
   Mexiletine
    D00639  Mexiletine hydrochloride (JP16/USP)
  CYP3A4
   Mexiletine
    D00639  Mexiletine hydrochloride (JP16/USP)
 Inhbitors
  CYP1A2
   Mexiletine
    D00639  Mexiletine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00639  Mexiletine hydrochloride
BRITE hierarchy
Other DBs
CAS: 
5370-01-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        14
            1   C8y C    22.8402  -16.9926
            2   C8y C    21.6292  -17.7005
            3   C8y C    22.8402  -15.6003
            4   O2a O    24.0511  -17.6946
            5   C8x C    20.4125  -16.9926
            6   C1a C    21.6292  -19.0986
            7   C8x C    21.6292  -14.8984
            8   C1a C    24.0511  -14.8984
            9   C1b C    25.2563  -16.9926
            10  C8x C    20.4125  -15.6003
            11  C1c C    26.4730  -17.6946
            12  C1a C    26.4730  -19.0986
            13  N1a N    27.6840  -16.9926
            14  X   Cl   31.3883  -16.8932
BOND        13
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 2
            10    9  11 1
            11   11  12 1
            12   11  13 1
            13    7  10 1

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