| Entry |
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| Name |
Propafenone hydrochloride (JP16/USP);
Rythmol (TN)
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| Product |
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| Generic |
PROPAFENONE HCL (American Health Packaging), PROPAFENONE HYDROCHLORIDE (Cardinal Health), PROPAFENONE HCL (McKesson Packaging Services a business unit of McKesson Corporation), PROPAFENONE HYDROCHLORIDE (Mutual Pharmaceutical), PROPAFENONE HYDROCHLORIDE (NCS HealthCare of KY), PROPAFENONE HYDROCHLORIDE (Par Pharmaceutical), PROPAFENONE HYDROCHLORIDE (Physicians Total Care), PROPAFENONE HYDROCHLORIDE (Qualitest Pharmaceuticals), PROPAFENONE (Rebel Distributors Corp), PROPAFENONE HYDROCHLORIDE (UDL Laboratories), PROPAFENONE HCL (Watson Laboratories) |
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| Formula |
C21H27NO3. HCl
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| Exact mass |
377.1758
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| Mol weight |
377.9049
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| Structure |
     |
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| Activity |
Cardiac depressant [anti-arrhythmic]
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| Remark |
Therapeutic category: ATC code: |
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| Comment |
Class I antiarrhythmic agent (Ic)
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| Target |
voltage-gated sodium channel (SCN1A) blocker [HSA: 6323] [KO: K04833]; voltage-gated sodium channel (SCN2A) blocker [HSA: 6326] [KO: K04834]; voltage-gated sodium channel (SCN3A) blocker [HSA: 6328] [KO: K04836]; voltage-gated sodium channel (SCN4A) blocker [HSA: 6329] [KO: K04837]; voltage-gated sodium channel (SCN5A) blocker [HSA: 6331] [KO: K04838]; voltage-gated sodium channel (SCN8A) blocker [HSA: 6334] [KO: K04840]; voltage-gated sodium channel (SCN9A) blocker [HSA: 6335] [KO: K04841]; beta1-adrenergic receptor antagonist [HSA: 153] [KO: K04141] |
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
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| Interaction |
Genomic biomarker: CYP2D6 [HSA: 1565]
CYP inhibition: CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565]
Transporter inhibition: ABCB1 [HSA: 5243]
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| Structure map |
| Antiarrhythmic drugs | | Sodium channel blocking drugs |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2129 Others
D00640 Propafenone hydrochloride (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BC Antiarrhythmics, class Ic
C01BC03 Propafenone
D00640 Propafenone hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
Cardiovascular Agents
Antiarrhythmics
Propafenone
D00640 Propafenone hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated cation channels
Na+ channel, SCN alpha, NaV1.x
voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
Propafenone [ATC:C01BC03]
D00640 Propafenone hydrochloride (JP16/USP)
voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
Propafenone [ATC:C01BC03]
D00640 Propafenone hydrochloride (JP16/USP)
voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
Propafenone [ATC:C01BC03]
D00640 Propafenone hydrochloride (JP16/USP)
voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
Propafenone [ATC:C01BC03]
D00640 Propafenone hydrochloride (JP16/USP)
voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
Propafenone [ATC:C01BC03]
D00640 Propafenone hydrochloride (JP16/USP)
voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
Propafenone [ATC:C01BC03]
D00640 Propafenone hydrochloride (JP16/USP)
voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
Propafenone [ATC:C01BC03]
D00640 Propafenone hydrochloride (JP16/USP)
K+ channel, KCNA, Kv1.x (Shaker)
voltage-gated potassium channel (KCNA5) [HSA:3741] [KO:K04878]
Propafenone [ATC:C01BC03]
D00640 Propafenone hydrochloride (JP16/USP)
K+ channel, KCNK, K2px.x
voltage-gated potassium channel (KCNK5) [HSA:8645] [KO:K04916]
Propafenone [ATC:C01BC03]
D00640 Propafenone hydrochloride (JP16/USP)
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| Other DBs |
CAS: 34183-22-7 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 26
1 C8y C 27.3415 -18.7772
2 C8y C 27.3474 -20.1862
3 O2a O 26.1247 -18.0844
4 C8x C 28.5641 -18.0785
5 C5a C 26.1363 -20.8906
6 C8x C 28.5641 -20.8849
7 C1b C 26.1363 -16.6871
8 C8x C 29.7753 -18.7772
9 C1b C 24.9311 -20.1919
10 O5a O 26.1422 -22.2880
11 C8x C 29.7693 -20.1803
12 C1c C 24.9311 -15.9825
13 C1b C 23.7259 -20.8965
14 C1b C 23.7259 -16.6928
15 O1a O 24.9253 -14.5851
16 C8y C 22.5090 -20.2036
17 N1b N 22.5149 -15.9941
18 C8x C 22.5090 -18.8005
19 C8x C 21.3097 -20.9082
20 C1b C 21.3097 -16.6987
21 C8x C 21.2921 -18.1135
22 C8x C 20.0869 -20.2212
23 C1b C 20.0928 -16.0000
24 C8x C 20.0754 -18.8121
25 C1a C 18.8819 -16.7045
26 X Cl 31.8596 -18.4395
BOND 26
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 1
7 4 8 1
8 5 9 1
9 5 10 2
10 6 11 1
11 7 12 1
12 9 13 1
13 12 14 1
14 12 15 1
15 13 16 1
16 14 17 1
17 16 18 2
18 16 19 1
19 17 20 1
20 18 21 1
21 19 22 2
22 20 23 1
23 21 24 2
24 23 25 1
25 8 11 2
26 22 24 1
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