KEGG   DRUG: Quinidine polygalacturonateHelp
Entry
D00643                      Drug                                   

Name
Quinidine polygalacturonate;
Cardioquin (TN)
Formula
C20H24N2O2. (C6H10O7)mon
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Cyp substrate
 DG01633  CYP3A substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
ATC code: C01BA01
Chemical structure group: DG00192
Product (DG00192): D00642<US> D02272<JP/US>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: SLC22A1 [HSA:6580], SLC22A3 [HSA:6581]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Transporter inhibition: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802], ABCB1 [HSA:5243]
Drug interaction
Structure map
map07025  Quinolines
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA01 Quinidine
      D00643  Quinidine polygalacturonate
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Quinidine
    D00643  Quinidine polygalacturonate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00643  Quinidine polygalacturonate
    SCN2A
     D00643  Quinidine polygalacturonate
    SCN3A
     D00643  Quinidine polygalacturonate
    SCN4A
     D00643  Quinidine polygalacturonate
    SCN5A
     D00643  Quinidine polygalacturonate
    SCN8A
     D00643  Quinidine polygalacturonate
    SCN9A
     D00643  Quinidine polygalacturonate
    SCN10A
     D00643  Quinidine polygalacturonate
    SCN11A
     D00643  Quinidine polygalacturonate
BRITE hierarchy
Other DBs
CAS: 27555-34-6
PubChem: 7847709
ChEBI: 28569
DrugBank: DB00908
LigandBox: D00643
KCF data Show

ATOM        37
            1   C8y C    15.8200  -25.3400
            2   C8y C    17.0100  -24.6400
            3   C8y C    15.8200  -26.7400
            4   C8x C    14.5600  -24.6400
            5   C1c C    17.0100  -23.2400
            6   C8x C    18.2000  -25.3400
            7   C8x C    14.5600  -27.4400
            8   N5x N    17.0100  -27.4400
            9   C8y C    13.3700  -25.3400
            10  C1y C    18.2700  -22.5400
            11  O1a O    15.8200  -22.5400
            12  C8x C    18.2000  -26.7400
            13  C8x C    13.3700  -26.7400
            14  O2a O    12.1800  -24.6400
            15  N1y N    19.6700  -21.6300
            16  C1x C    17.5000  -21.4900
            17  C1a C    12.1800  -23.2400
            18  C1x C    19.6700  -20.4400
            19  C1x C    21.2100  -22.4700
            20  C1y C    18.9000  -20.6500
            21  C1y C    18.9000  -19.6700
            22  C1x C    20.5100  -21.3500
            23  C2b C    18.4100  -18.3400
            24  C2a C    19.2500  -17.2200
            25  C1c C    26.9500  -26.0400
            26  C1c C    25.7600  -25.4100
            27  C1c C    28.1400  -25.4100
            28  O1a O    26.9500  -27.5100
            29  C1c C    24.5000  -26.0400
            30  O1a O    25.7600  -23.9400
            31  C6a C    29.4000  -26.0400
            32  O1a O    28.1400  -23.9400
            33  C4a C    23.3100  -25.4100
            34  O1a O    24.5000  -27.5100
            35  O6a O    30.5900  -25.4100
            36  O6a O    29.4000  -27.5100
            37  O4a O    22.1200  -26.0400
BOND        39
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1 #Down
            11    6  12 1
            12    7  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16   14  17 1
            17   15  18 1
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   19  22 1
            22   21  23 1 #Up
            23   23  24 2
            24    8  12 2
            25    9  13 2
            26   20  21 1
            27   20  22 1
            28   25  26 1
            29   25  27 1
            30   25  28 1 #Down
            31   26  29 1
            32   26  30 1 #Up
            33   27  31 1
            34   27  32 1 #Down
            35   29  33 1
            36   29  34 1 #Up
            37   31  35 1
            38   31  36 2
            39   33  37 2
BRACKET     1    21.4200  -28.5600   21.4200  -23.1000
            1    32.4800  -23.1000   32.4800  -28.5600
            1  MON
 ORIGINAL  1   26  27  28  29  30  31  32  33  34  35  36  37  38
 REPEAT    1

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