KEGG   DRUG: D00646Help
Entry
D00646                      Drug                                   

Name
Tolterodine (USAN/INN)
Formula
C22H31NO
Exact mass
325.2406
Mol weight
325.4876
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticholinergic
Remark
Same as: 
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor M3 antagonist [HSA:1131] [KO:K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD07 Tolterodine
      D00646  Tolterodine (USAN/INN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Tolterodine
    D00646  Tolterodine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M3
     Tolterodine
      D00646  Tolterodine (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Tolterodine
    D00646  Tolterodine (USAN/INN)
  CYP3A4
   Tolterodine
    D00646  Tolterodine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
124937-51-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C1c C    14.3599  -16.8800
            2   N1c N    15.5739  -17.5809
            3   C1b C    16.7880  -16.8800
            4   C1b C    18.0020  -17.5809
            5   C1c C    19.2160  -16.8800
            6   C8y C    20.4301  -17.5809
            7   C8x C    21.6441  -16.8800
            8   C8y C    22.8582  -17.5809
            9   C1a C    24.0723  -16.8800
            10  C1a C    13.1458  -17.5809
            11  C1a C    14.3599  -15.4781
            12  C1c C    15.5739  -18.9825
            13  C1a C    14.3430  -19.6934
            14  C1a C    16.7711  -19.6739
            15  C8y C    19.2160  -15.4782
            16  C8y C    20.4301  -18.9824
            17  C8x C    22.8582  -18.9826
            18  C8x C    21.6650  -19.6957
            19  O1a O    19.2369  -19.6715
            20  C8x C    20.4152  -14.7858
            21  C8x C    20.4151  -13.3839
            22  C8x C    19.2010  -12.6831
            23  C8x C    18.0018  -13.3755
            24  C8x C    18.0019  -14.7774
BOND        25
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     5   4 1 #Down
            5     5   6 1
            6     6   7 1
            7     7   8 2
            8     8   9 1
            9     1  10 1
            10    1  11 1
            11    2  12 1
            12   12  13 1
            13   12  14 1
            14    5  15 1
            15    6  16 2
            16    8  17 1
            17   16  18 1
            18   18  17 2
            19   16  19 1
            20   15  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   15  24 1

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