KEGG   DRUG: D00649Help
Entry
D00649                      Drug                                   

Name
Amiloride hydrochloride (USP);
Midamor (TN)
Product
  Generic
Formula
C6H8ClN7O. 2H2O. HCl
Exact mass
301.0457
Mol weight
302.1185
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic
Remark
ATC code: 
Drug group: 
Target
Epithelial sodium channel (SCNN) blocker [HSA:6337 6338 6340] [KO:K04824 K04825 K04827]
  Pathway
hsa04960  Aldosterone-regulated sodium reabsorption  
 
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03D POTASSIUM-SPARING AGENTS
    C03DB Other potassium-sparing agents
     C03DB01 Amiloride
      D00649  Amiloride hydrochloride (USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Potassium-sparing
   Amiloride
    D00649  Amiloride hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Epithelial and related channels
   Epithelial sodium channel (SCNN)
    renal epithelial Na+ channel (SCNN)
     Amiloride
      D00649  Amiloride hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
17440-83-4
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        18
            1   C8y C    22.0858  -17.2962
            2   C5a C    23.3026  -17.9925
            3   C8y C    22.0858  -15.8920
            4   N5x N    20.8805  -17.9925
            5   N1b N    24.5137  -17.2904
            6   O5a O    23.3026  -19.3907
            7   N5x N    20.8805  -15.1959
            8   N1a N    23.3026  -15.1959
            9   C8y C    19.6636  -17.2962
            10  C2c C    25.7247  -17.9925
            11  C8y C    19.6636  -15.8920
            12  X   Cl   18.4466  -17.9925
            13  N1a N    26.9358  -17.2904
            14  N2a N    25.7247  -19.3907
            15  N1a N    18.4466  -15.1959
            16  O0  O    32.0313  -18.1505
            17  X   Cl   31.6217  -15.6801
            18  O0  O    32.0313  -18.1505
BOND        15
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    7  11 1
            11    9  12 1
            12   10  13 1
            13   10  14 2
            14   11  15 1
            15    9  11 2
BRACKET     1    30.0300  -19.1100   30.0300  -17.2200
            1    32.6200  -17.2200   32.6200  -19.1100
            1  2
 ORIGINAL  1   16
 REPEAT    1   18

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