KEGG   DRUG: BrinzolamideHelp
Entry
D00652                      Drug                                   

Name
Brinzolamide (JAN/USP/INN);
Azopt (TN)
Product
Formula
C12H21N3O5S3
Exact mass
383.0643
Mol weight
383.5072
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01534  Carbonic anhydrase inhibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiglaucoma, Carbonic anhydrase inhibitor
Target
CA2 [HSA:760] [KO:K18245]
  Pathway
Proximal tubule bicarbonate reclamation
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EC Carbonic anhydrase inhibitors
     S01EC04 Brinzolamide
      D00652  Brinzolamide (JAN/USP/INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Brinzolamide
    D00652  Brinzolamide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00652  Brinzolamide (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases
   carbonic anhydrase 2
    Brinzolamide
     D00652  Brinzolamide (JAN/USP/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00652
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00652
BRITE hierarchy
Other DBs
CAS: 
138890-62-7
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    22.7083  -13.1828
            2   C8y C    22.7024  -14.5595
            3   S2x S    23.8982  -12.5004
            4   S2x S    21.3899  -12.7628
            5   C1y C    23.8982  -15.2479
            6   C8x C    21.3957  -14.9854
            7   N1y N    25.0825  -13.1828
            8   O3c O    22.6383  -11.5902
            9   O3c O    25.0067  -11.6602
            10  C8y C    20.5849  -13.8828
            11  C1x C    25.0825  -14.5595
            12  N1b N    23.8982  -16.6246
            13  C1b C    26.2784  -12.5004
            14  S4a S    19.2140  -13.8828
            15  C1b C    25.0884  -17.3073
            16  C1b C    27.4919  -13.2062
            17  N1a N    19.1614  -15.4812
            18  O3c O    19.1614  -12.5004
            19  O3c O    17.7730  -13.8887
            20  C1a C    25.0942  -18.6839
            21  C1b C    28.7052  -12.5004
            22  O2a O    29.9185  -13.2062
            23  C1a C    31.1261  -12.5004
BOND        24
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     3   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1 #Down
            12    7  13 1
            13   10  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 2
            18   14  19 2
            19   15  20 1
            20   16  21 1
            21   21  22 1
            22   22  23 1
            23    6  10 2
            24    7  11 1

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