KEGG   DRUG: D00658Help
Entry
D00658                      Drug                                   

Name
Trichlormethiazide (JP16/USP/INN);
Naqua (TN)
Formula
C8H8Cl3N3O4S2
Exact mass
378.9022
Mol weight
380.6558
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive;
Diuretic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
Na+-Cl- symport inhibitor [HSA:6559] [KO:K14426]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Ion transporter inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2132  Thiazides
     D00658  Trichlormethiazide (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03A LOW-CEILING DIURETICS, THIAZIDES
    C03AA Thiazides, plain
     C03AA06 Trichlormethiazide
      D00658  Trichlormethiazide (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3 [HSA:6559] [KO:K14426] [TC:2.A.30.4.2]
     Trichlormethiazide [ATC:C03AA06]
      D00658  Trichlormethiazide (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
133-67-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C8y C    24.9600  -17.0201
            2   C8y C    25.0243  -18.4245
            3   C8x C    26.1773  -16.3296
            4   S2x S    23.7547  -16.3238
            5   N1x N    23.7547  -19.1210
            6   C8x C    26.1656  -19.1267
            7   C8y C    27.3827  -17.0318
            8   N1x N    22.5374  -17.0201
            9   O3c O    22.5316  -15.6216
            10  O3c O    24.9543  -15.6158
            11  C1y C    22.5374  -18.4245
            12  C8y C    27.3769  -18.4305
            13  S4a S    28.5823  -16.3296
            14  C1c C    21.3203  -19.1210
            15  X   Cl   28.5765  -19.1267
            16  N1a N    29.7936  -15.4811
            17  O3c O    27.5933  -15.3290
            18  O3c O    29.6356  -17.1781
            19  X   Cl   20.1090  -18.4245
            20  X   Cl   21.3844  -20.5195
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     4   9 2
            9     4  10 2
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 2
            17   13  18 2
            18   14  19 1
            19   14  20 1
            20    7  12 1
            21    8  11 1

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