KEGG   DRUG: D00661Help
Entry
D00661                      Drug                                   

Name
Cevimeline hydrochloride hydrate (JAN);
Cevimeline hydrochloride (USAN);
Evoxac (TN);
Saligren (TN)
Product
  Generic
Formula
(C10H17NOS)2. 2HCl. H2O
Exact mass
488.1701
Mol weight
489.5633
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of dry mouth in Sjogren's syndrome [DS:H00162];
Alzheimer's disease treatment [adjunct]
Remark
Therapeutic category: 
ATC code: 
Target
muscarinic cholinergic receptor M1, M3 agonist [HSA:1128 1131] [KO:K04129 K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00661  Cevimeline hydrochloride hydrate (JAN); Cevimeline hydrochloride (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX03 Cevimeline
      D00661  Cevimeline hydrochloride hydrate (JAN); Cevimeline hydrochloride (USAN)
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Cevimeline
   D00661  Cevimeline hydrochloride hydrate (JAN); Cevimeline hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M1 [HSA:1128] [KO:K04129]
     Cevimeline [ATC:N07AX03]
      D00661  Cevimeline hydrochloride hydrate (JAN); Cevimeline hydrochloride (USAN)
    muscarinic cholinergic receptor M3 [HSA:1131] [KO:K04131]
     Cevimeline [ATC:N07AX03]
      D00661  Cevimeline hydrochloride hydrate (JAN); Cevimeline hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
153504-70-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C1z C    24.9536  -15.4572
            2   C1y C    24.9536  -14.0450
            3   C1x C    23.6698  -16.2274
            4   C1x C    23.6698  -13.2748
            5   C1x C    24.0550  -14.9437
            6   N1y N    22.3861  -15.4572
            7   C1x C    22.3861  -14.0450
            8   C1x C    23.4130  -14.4302
            9   O2x O    24.9536  -16.8968
            10  C1y C    26.3228  -17.3417
            11  S2x S    27.1689  -16.1770
            12  C1x C    26.3228  -15.0123
            13  C1a C    26.7689  -18.7147
            14  O0  O    31.1826  -14.4759
            15  X   Cl   31.0386  -16.9232
            16  C1z C    24.9536  -15.4572
            17  C1y C    24.9536  -14.0450
            18  C1x C    23.6698  -13.2748
            19  C1x C    22.3861  -14.0450
            20  N1y N    22.3861  -15.4572
            21  C1x C    23.6698  -16.2274
            22  C1x C    23.4130  -14.4302
            23  C1x C    24.0550  -14.9437
            24  O2x O    24.9536  -16.8968
            25  C1y C    26.3228  -17.3417
            26  S2x S    27.1689  -16.1770
            27  C1x C    26.3228  -15.0123
            28  C1a C    26.7689  -18.7147
            29  X   Cl   31.0386  -16.9232
BOND        30
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   7 1
            9     6   8 1
            10    1   9 1 #Up
            11    9  10 1
            12   10  11 1
            13   11  12 1
            14    1  12 1
            15   10  13 1 #Down
            16   16  17 1
            17   16  21 1
            18   17  18 1
            19   17  23 1
            20   21  20 1
            21   18  19 1
            22   23  22 1
            23   20  19 1
            24   20  22 1
            25   16  24 1 #Up
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   16  27 1
            30   25  28 1 #Down
BRACKET     1    21.7000  -19.3900   21.7000  -12.8100
            1    28.1400  -12.8100   28.1400  -19.3900
            1  2
 ORIGINAL  1    1   2   4   7   6   3   8   5   9  10  11  12  13
 REPEAT    1   16  17  18  19  20  21  22  23  24  25  26  27  28
            2    29.4700  -17.7800   29.4700  -15.9600
            2    31.7100  -15.9600   31.7100  -17.7800
            2  2
 ORIGINAL  2   15
 REPEAT    2   29

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