KEGG   DRUG: Cevimeline hydrochlorideHelp
Entry
D00661                      Drug                                   

Name
Cevimeline hydrochloride (USAN);
Cevimeline hydrochloride hydrate (JAN);
Evoxac (TN);
Saligren (TN)
Product
  Generic
Formula
(C10H17NOS)2. 2HCl. H2O
Exact mass
488.1701
Mol weight
489.5633
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
Other
 DG01719  Parasympathomimetic agent
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Treatment of dry mouth in Sjogren's syndrome, Alzheimer's disease treatment [adjunct]
Target
muscarinic cholinergic receptor M1, M3 [HSA:1128 1131] [KO:K04129 K04131]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX03 Cevimeline
      D00661  Cevimeline hydrochloride (USAN)
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Cevimeline
   D00661  Cevimeline hydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00661  Cevimeline hydrochloride (USAN); Cevimeline hydrochloride hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M1
     Cevimeline
      D00661  Cevimeline hydrochloride (USAN)
    muscarinic cholinergic receptor M3
     Cevimeline
      D00661  Cevimeline hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Cevimeline
    D00661  Cevimeline hydrochloride (USAN)
  CYP3A4
   Cevimeline
    D00661  Cevimeline hydrochloride (USAN)
Gastrointestinal agents [br08371.html]
 Agent for intraoral diseases
  D00661
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00661
BRITE hierarchy
Other DBs
CAS: 
153504-70-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C1z C    24.9536  -15.4572
            2   C1y C    24.9536  -14.0450
            3   C1x C    23.6698  -16.2274
            4   C1x C    23.6698  -13.2748
            5   C1x C    24.0550  -14.9437
            6   N1y N    22.3861  -15.4572
            7   C1x C    22.3861  -14.0450
            8   C1x C    23.4130  -14.4302
            9   O2x O    24.9536  -16.8968
            10  C1y C    26.3228  -17.3417
            11  S2x S    27.1689  -16.1770
            12  C1x C    26.3228  -15.0123
            13  C1a C    26.7689  -18.7147
            14  O0  O    31.1826  -14.4759
            15  X   Cl   31.0386  -16.9232
            16  C1z C    24.9536  -15.4572
            17  C1y C    24.9536  -14.0450
            18  C1x C    23.6698  -13.2748
            19  C1x C    22.3861  -14.0450
            20  N1y N    22.3861  -15.4572
            21  C1x C    23.6698  -16.2274
            22  C1x C    23.4130  -14.4302
            23  C1x C    24.0550  -14.9437
            24  O2x O    24.9536  -16.8968
            25  C1y C    26.3228  -17.3417
            26  S2x S    27.1689  -16.1770
            27  C1x C    26.3228  -15.0123
            28  C1a C    26.7689  -18.7147
            29  X   Cl   31.0386  -16.9232
BOND        30
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   7 1
            9     6   8 1
            10    1   9 1 #Up
            11    9  10 1
            12   10  11 1
            13   11  12 1
            14    1  12 1
            15   10  13 1 #Down
            16   16  17 1
            17   16  21 1
            18   17  18 1
            19   17  23 1
            20   21  20 1
            21   18  19 1
            22   23  22 1
            23   20  19 1
            24   20  22 1
            25   16  24 1 #Up
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   16  27 1
            30   25  28 1 #Down
BRACKET     1    21.7000  -19.3900   21.7000  -12.8100
            1    28.1400  -12.8100   28.1400  -19.3900
            1  2
 ORIGINAL  1    1   2   4   7   6   3   8   5   9  10  11  12  13
 REPEAT    1   16  17  18  19  20  21  22  23  24  25  26  27  28
            2    29.4700  -17.7800   29.4700  -15.9600
            2    31.7100  -15.9600   31.7100  -17.7800
            2  2
 ORIGINAL  2   15
 REPEAT    2   29

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