| Entry |
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| Name |
Cetirizine hydrochloride (JP16/USAN);
Zyrtec (TN)
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| Product |
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| Generic |
CETIRIZINE HYDROCHLORIDE (Amneal Pharmaceuticals), CETIRIZINE HYDROCHLORIDE (Aurobindo Pharma Limited), CETIRIZINE HYDROCHLORIDE (Bryant Ranch Prepack), CETIRIZINE HYDROCHLORIDE (Caraco Pharmaceutical Laboratories), CETIRIZINE HYDROCHLORIDE (Cypress Pharmaceutical), CETIRIZINE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), CETIRIZINE HYDROCHLORIDE (Perrigo New York), CETIRIZINE HYDROCHLORIDE (Preferred Pharmaceuticals), CETIRIZINE HYDROCHLORIDE (Qualitest Pharmaceuticals), CETIRIZINE HYDROCHLORIDE (REMEDYREPACK), CETIRIZINE HYDROCHLORIDE (REMEDYREPACK), CETIRIZINE HYDROCHLORIDE (Silarx Pharmaceuitcals), CETIRIZINE HYDROCHLORIDE (Teva Pharmaceuticals USA), CETIRIZINE HYDROCHLORIDE (WOCKHARDT LLC.) |
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| Formula |
C21H25ClN2O3. 2HCl
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| Exact mass |
460.1087
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| Mol weight |
461.8097
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| Structure |
     |
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| Activity |
Antihistaminic
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| Remark |
Therapeutic category: ATC code: |
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| Target |
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| Pathway |
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction | |
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| Metabolism |
Transporter: ABCB1 (P-gp) [HSA: 5243], SLC22A2 [HSA: 6582]
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| Interaction |
Transporter inhibition: SLC22A2 [HSA: 6582]
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| Structure map |
| Histamine H1 receptor antagonists |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
449 Miscellaneous
4490 Miscellaneous
D00664 Cetirizine hydrochloride (JP16/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AE Piperazine derivatives
R06AE07 Cetirizine
D00664 Cetirizine hydrochloride (JP16/USAN)
USP drug classification [BR:br08302]
Respiratory Tract Agents
Antihistamines
Histamine1 (H1) Receptor Antagonists, Mildly / Non-sedating
Cetirizine
D00664 Cetirizine hydrochloride (JP16/USAN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
H1-receptor [HSA:3269] [KO:K04149]
Cetirizine [ATC:R06AE07]
D00664 Cetirizine hydrochloride (JP16/USAN)
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| Other DBs |
CAS: 83881-52-1 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 29
1 C8x C 22.3396 -18.4537
2 C8y C 22.3396 -19.8566
3 C8x C 23.5544 -20.5580
4 C8x C 24.7694 -19.8566
5 C8y C 24.7694 -18.4537
6 C8x C 23.5544 -17.7523
7 C8x C 27.1992 -19.8566
8 C8y C 27.1992 -18.4537
9 C1c C 25.9843 -17.7523
10 C8x C 28.4141 -20.5580
11 C8x C 29.6290 -19.8566
12 C8x C 29.6290 -18.4537
13 C8x C 28.4141 -17.7523
14 N1y N 25.9843 -16.3494
15 C1x C 27.2013 -15.6468
16 C1x C 27.2013 -14.2439
17 N1y N 25.9863 -13.5425
18 C1x C 24.7694 -14.2451
19 C1x C 24.7694 -15.6480
20 X Cl 21.1247 -20.5580
21 C1b C 25.9863 -12.1408
22 C1b C 27.2018 -11.4391
23 O2a O 28.3999 -12.1310
24 C1b C 29.5895 -11.4443
25 C6a C 30.7833 -12.1337
26 O6a O 31.9752 -11.4456
27 O6a O 30.7833 -13.5434
28 X Cl 31.6686 -16.0688
29 X Cl 31.6686 -16.0688
BOND 29
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 9 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 14 19 1
22 2 20 1
23 17 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 24 25 1
28 25 26 1
29 25 27 2
BRACKET 1 30.2400 -16.8000 30.2400 -15.2600
1 32.3400 -15.2600 32.3400 -16.8000
1 2
ORIGINAL 1 28
REPEAT 1 29
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