KEGG   DRUG: Cetirizine hydrochlorideHelp
Entry
D00664                      Drug                                   

Name
Cetirizine hydrochloride (JP17/USAN);
Zyrtec (TN)
Product
  Generic
CETIRIZINE HYDROCHLORIDE (Amneal Pharmaceuticals), CETIRIZINE HYDROCHLORIDE (Breckenridge Pharmaceutical), CETIRIZINE HYDROCHLORIDE (Bryant Ranch Prepack), CETIRIZINE HYDROCHLORIDE (Caraco Pharmaceutical Laboratories), CETIRIZINE HYDROCHLORIDE (Carilion Materials Management), CETIRIZINE HYDROCHLORIDE (Heritage Pharmaceuticals), CETIRIZINE HYDROCHLORIDE (Nostrum Laboratories), CETIRIZINE HYDROCHLORIDE (Perrigo New York), CETIRIZINE HYDROCHLORIDE (Preferred Pharmaceuticals), CETIRIZINE HYDROCHLORIDE (Preferred Pharmaceuticals), CETIRIZINE HYDROCHLORIDE (Preferred Pharmaceuticals), CETIRIZINE HYDROCHLORIDE (Proficient Rx LP), CETIRIZINE HYDROCHLORIDE (REMEDYREPACK), CETIRIZINE HYDROCHLORIDE (REMEDYREPACK), CETIRIZINE HYDROCHLORIDE (REMEDYREPACK), CETIRIZINE HYDROCHLORIDE (Silarx Pharmaceuticals), CETIRIZINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), CETIRIZINE HYDROCHLORIDE (WOCKHARDT LLC.)
Formula
C21H25ClN2O3. 2HCl
Exact mass
460.1087
Mol weight
461.8097
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Transporter substrate
 DG01665  P-glycoprotein substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiallergic, H1-receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Metabolism
Transporter: ABCB1 [HSA:5243], SLC22A2 [HSA:6582]
Interaction
Transporter inhibition: SLC22A2 [HSA:6582]
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AE Piperazine derivatives
     R06AE07 Cetirizine
      D00664  Cetirizine hydrochloride (JP17/USAN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Cetirizine
    D00664  Cetirizine hydrochloride (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D00664  Cetirizine hydrochloride (JP17/USAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D00664  Cetirizine hydrochloride (JP17/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Cetirizine
    D00664  Cetirizine hydrochloride (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Cetirizine
      D00664  Cetirizine hydrochloride (JP17/USAN)
Cytochrome P450 interactions [BR:br08309]
 Transporter inhibitors
  SLC22A2
   Cetirizine
    D00664  Cetirizine hydrochloride (JP17/USAN)
 Transporter substrates
  ABCB1
   Cetirizine
    D00664  Cetirizine hydrochloride (JP17/USAN)
  SLC22A2
   Cetirizine
    D00664  Cetirizine hydrochloride (JP17/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00664  Cetirizine hydrochloride
  D00664  Cetirizine hydrochloride tablets
Anti-allergic agents [br08362.html]
 D00664
Rx-to-OTC switch list in the USA [br08315.html]
 D00664
Rx-to-OTC switch list in Japan [br08314.html]
 D00664
BRITE hierarchy
Other DBs
CAS: 
83881-52-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C8x C    22.3396  -18.4537
            2   C8y C    22.3396  -19.8566
            3   C8x C    23.5544  -20.5580
            4   C8x C    24.7694  -19.8566
            5   C8y C    24.7694  -18.4537
            6   C8x C    23.5544  -17.7523
            7   C8x C    27.1992  -19.8566
            8   C8y C    27.1992  -18.4537
            9   C1c C    25.9843  -17.7523
            10  C8x C    28.4141  -20.5580
            11  C8x C    29.6290  -19.8566
            12  C8x C    29.6290  -18.4537
            13  C8x C    28.4141  -17.7523
            14  N1y N    25.9843  -16.3494
            15  C1x C    27.2013  -15.6468
            16  C1x C    27.2013  -14.2439
            17  N1y N    25.9863  -13.5425
            18  C1x C    24.7694  -14.2451
            19  C1x C    24.7694  -15.6480
            20  X   Cl   21.1247  -20.5580
            21  C1b C    25.9863  -12.1408
            22  C1b C    27.2018  -11.4391
            23  O2a O    28.3999  -12.1310
            24  C1b C    29.5895  -11.4443
            25  C6a C    30.7833  -12.1337
            26  O6a O    31.9752  -11.4456
            27  O6a O    30.7833  -13.5434
            28  X   Cl   31.6686  -16.0688
            29  X   Cl   31.6686  -16.0688
BOND        29
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22    2  20 1
            23   17  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   25  27 2
BRACKET     1    30.2400  -16.8000   30.2400  -15.2600
            1    32.3400  -15.2600   32.3400  -16.8000
            1  2
 ORIGINAL  1   28
 REPEAT    1   29

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