KEGG   DRUG: D00665Help
Entry
D00665                      Drug                                   

Name
Chlorpheniramine maleate (JP16/USP);
Chlor-trimeton (TN);
Teldrin (TN)
Formula
C16H19ClN2. C4H4O4
Exact mass
390.1346
Mol weight
390.8606
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB04 Chlorphenamine
      D00665  Chlorpheniramine maleate (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4419  Others
     D00665  Chlorpheniramine maleate (JP16/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00665  Chlorpheniramine maleate (JP16/USP)
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D00665  Chlorpheniramine maleate (JP16/USP)
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00665  Chlorpheniramine maleate (JP16/USP)
  -- Hemorrhoid oinments
   D00665  Chlorpheniramine maleate (JP16/USP)
 Allergic agents
  52 Antihistamine based drugs
   D00665  Chlorpheniramine maleate (JP16/USP)
  -- Allergic agents (oral use)
   D00665  Chlorpheniramine maleate (JP16/USP)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00665  Chlorpheniramine maleate (JP16/USP)
  -- Eczematous and dermatitis remedies
   D00665  Chlorpheniramine maleate (JP16/USP)
 Agents for ophthalmologic use
  64 Allergy eye drops
   D00665  Chlorpheniramine maleate (JP16/USP)
  67 Eyewash
   D00665  Chlorpheniramine maleate (JP16/USP)
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D00665  Chlorpheniramine maleate (JP16/USP)
  70 Nasal sprays for inflammation
   D00665  Chlorpheniramine maleate (JP16/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Category 2
  Inorganic and organic chemicals
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP16/USP)
 Category 3
  Inorganic and organic chemicals
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Chlorphenamine
      D00665  Chlorpheniramine maleate (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP16/USP)
  CYP3A4
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP16/USP)
  CYP3A5
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP16/USP)
  CYP3A7
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP16/USP)
 Inhbitors
  CYP2D6
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00665  Chlorpheniramine maleate
  D00665  Chlorpheniramine maleate powder
  D00665  Chlorpheniramine maleate tablets
  D00665  Chlorpheniramine maleate injection
BRITE hierarchy
Other DBs
CAS: 
113-92-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C2b C    19.2774  -11.8495
            2   C2b C    17.7264  -11.8554
            3   C6a C    19.9250  -12.9665
            4   C6a C    17.0845  -12.9784
            5   O6a O    19.2832  -14.0898
            6   O6a O    21.2204  -12.9607
            7   O6a O    15.7890  -12.9784
            8   O6a O    17.7381  -14.0956
            9   C8x C     7.0000  -14.8400
            10  C8y C     7.0000  -16.2400
            11  C8x C     8.2124  -16.9400
            12  C8x C     9.4249  -16.2400
            13  C8y C     9.4249  -14.8400
            14  C8x C     8.2124  -14.1400
            15  C8x C    11.8497  -16.2400
            16  C8y C    11.8497  -14.8400
            17  C1c C    10.6373  -14.1400
            18  C8x C    13.0622  -16.9400
            19  C8x C    14.2746  -16.2400
            20  C8x C    14.2746  -14.8400
            21  N5x N    13.0622  -14.1400
            22  X   Cl    5.7876  -16.9400
            23  C1b C    10.6373  -12.7400
            24  C1b C    11.8518  -12.0388
            25  N1c N    11.8518  -10.6402
            26  C1a C    13.0479   -9.9495
            27  C1a C    10.6230   -9.9306
BOND        27
            1     1   2 2
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14   15  16 1
            15   16  17 1
            16   13  17 1
            17   15  18 2
            18   18  19 1
            19   19  20 2
            20   20  21 1
            21   16  21 2
            22   10  22 1
            23   17  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   25  27 1

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