| Entry |
|
|---|
| Name |
Chlorpheniramine maleate (JP16/USP);
Chlor-trimeton (TN);
Teldrin (TN)
|
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| Formula |
C16H19ClN2. C4H4O4
|
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| Exact mass |
390.1346
|
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| Mol weight |
390.8606
|
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| Structure |
     |
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| Activity |
Antihistaminic
|
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Target |
|
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| Pathway |
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction | |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577], CYP3A7 [HSA: 1551]
|
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
 |
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| Structure map |
| Histamine H1 receptor antagonists |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
441 Antihistamines
4419 Others
D00665 Chlorpheniramine maleate (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AB Substituted alkylamines
R06AB04 Chlorphenamine
D00665 Chlorpheniramine maleate (JP16/USP)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
H1-receptor [HSA:3269] [KO:K04149]
Chlorphenamine [ATC:R06AB04]
D00665 Chlorpheniramine maleate (JP16/USP)
 |
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| Other DBs |
CAS: 113-92-8 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 27
1 C2b C 19.2774 -11.8495
2 C2b C 17.7264 -11.8554
3 C6a C 19.9250 -12.9665
4 C6a C 17.0845 -12.9784
5 O6a O 19.2832 -14.0898
6 O6a O 21.2204 -12.9607
7 O6a O 15.7890 -12.9784
8 O6a O 17.7381 -14.0956
9 C8x C 7.0000 -14.8400
10 C8y C 7.0000 -16.2400
11 C8x C 8.2124 -16.9400
12 C8x C 9.4249 -16.2400
13 C8y C 9.4249 -14.8400
14 C8x C 8.2124 -14.1400
15 C8x C 11.8497 -16.2400
16 C8y C 11.8497 -14.8400
17 C1c C 10.6373 -14.1400
18 C8x C 13.0622 -16.9400
19 C8x C 14.2746 -16.2400
20 C8x C 14.2746 -14.8400
21 N5x N 13.0622 -14.1400
22 X Cl 5.7876 -16.9400
23 C1b C 10.6373 -12.7400
24 C1b C 11.8518 -12.0388
25 N1c N 11.8518 -10.6402
26 C1a C 13.0479 -9.9495
27 C1a C 10.6230 -9.9306
BOND 27
1 1 2 2
2 1 3 1
3 2 4 1
4 3 5 1
5 3 6 2
6 4 7 1
7 4 8 2
8 9 10 2
9 10 11 1
10 11 12 2
11 12 13 1
12 13 14 2
13 9 14 1
14 15 16 1
15 16 17 1
16 13 17 1
17 15 18 2
18 18 19 1
19 19 20 2
20 20 21 1
21 16 21 2
22 10 22 1
23 17 23 1
24 23 24 1
25 24 25 1
26 25 26 1
27 25 27 1
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