| Entry |
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| Name |
Clemastine fumarate (JP16/USP);
Tavist (TN)
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| Product |
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| Generic |
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| Formula |
C21H26ClNO. C4H4O4
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| Exact mass |
459.1813
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| Mol weight |
459.9624
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| Structure |
     |
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| Activity |
Antihistaminic
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| Remark |
Therapeutic category: ATC code: |
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| Target |
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| Pathway |
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction | |
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
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| Structure map |
| Histamine H1 receptor antagonists |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
441 Antihistamines
4419 Others
D00666 Clemastine fumarate (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA14 Clemastine
D00666 Clemastine fumarate (JP16/USP)
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AA Aminoalkyl ethers
R06AA04 Clemastine
D00666 Clemastine fumarate (JP16/USP)
USP drug classification [BR:br08302]
Respiratory Tract Agents
Antihistamines
Histamine1 (H1) Receptor Antagonists, Sedating
Clemastine
D00666 Clemastine fumarate (JP16/USP)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
H1-receptor [HSA:3269] [KO:K04149]
Clemastine [ATC:D04AA14 R06AA04]
D00666 Clemastine fumarate (JP16/USP)
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| Other DBs |
CAS: 14976-57-9 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 32
1 C2b C 29.0912 -14.7933
2 C2b C 30.2988 -14.0933
3 C6a C 27.8838 -14.0992
4 C6a C 31.5181 -14.7876
5 O6a O 26.6703 -14.7993
6 O6a O 27.8721 -12.6991
7 O6a O 32.7256 -14.0875
8 O6a O 31.5064 -16.1877
9 C1y C 23.9026 -11.9129
10 N1y N 23.9026 -10.5120
11 C1a C 22.6687 -9.7996
12 C1x C 25.2349 -12.3458
13 C1x C 26.0583 -11.2124
14 C1x C 25.2349 -10.0792
15 C8x C 16.6632 -14.7099
16 C8y C 16.6632 -16.1107
17 C8x C 17.8763 -16.8111
18 C8x C 19.0896 -16.1107
19 C8y C 19.0896 -14.7099
20 C8x C 17.8763 -14.0095
21 C1d C 20.3027 -14.0095
22 X Cl 15.4501 -16.8111
23 O2a O 20.3027 -12.6087
24 C1b C 21.5179 -11.9071
25 C1b C 22.7151 -12.5985
26 C8x C 21.5158 -16.1107
27 C8y C 21.5158 -14.7099
28 C8x C 22.7290 -16.8111
29 C8x C 23.9421 -16.1107
30 C8x C 23.9421 -14.7099
31 C8x C 22.7290 -14.0095
32 C1a C 19.0896 -13.3091
BOND 33
1 1 2 2
2 1 3 1
3 2 4 1
4 3 5 1
5 3 6 2
6 4 7 1
7 4 8 2
8 9 10 1
9 10 11 1
10 9 12 1
11 12 13 1
12 13 14 1
13 10 14 1
14 15 16 2
15 16 17 1
16 17 18 2
17 18 19 1
18 19 20 2
19 15 20 1
20 19 21 1
21 16 22 1
22 21 23 1
23 23 24 1
24 24 25 1
25 26 27 1
26 26 28 2
27 28 29 1
28 29 30 2
29 30 31 1
30 27 31 2
31 21 27 1 #Down
32 21 32 1 #Up
33 9 25 1 #Down
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