KEGG   DRUG: D00668Help
Entry
D00668                      Drug                                   

Name
d-Chlorpheniramine maleate (JP16);
Dexchlorpheniramine maleate (USP);
Mylaramine (TN);
Polaramine (TN)
Product
  Generic
Formula
C16H19ClN2. C4H4O4
Exact mass
390.1346
Mol weight
390.8606
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB02 Dexchlorpheniramine
      D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4419  Others
     D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
 Allergic agents
  52 Antihistamine based drugs
   D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
  -- Allergic agents (oral use)
   D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Dexchlorpheniramine
      D00668  Dexchlorpheniramine maleate (USP)
     Chlorphenamine
      D00668  Dexchlorpheniramine maleate (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Dexchlorpheniramine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
  CYP3A4
   Dexchlorpheniramine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
  CYP3A5
   Dexchlorpheniramine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
  CYP3A7
   Dexchlorpheniramine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
 Inhbitors
  CYP2D6
   Dexchlorpheniramine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00668  d-Chlorpheniramine maleate
BRITE hierarchy
Other DBs
CAS: 
2438-32-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C8x C    20.6148  -17.3864
            2   C8y C    20.6148  -18.7909
            3   C8x C    21.8313  -19.4932
            4   C8x C    23.0477  -18.7909
            5   C8y C    23.0477  -17.3864
            6   C8x C    21.8313  -16.6840
            7   C8x C    25.4806  -18.7909
            8   C8y C    25.4806  -17.3864
            9   C1c C    24.2641  -16.6840
            10  C8x C    26.6971  -19.4932
            11  C8x C    27.9134  -18.7909
            12  C8x C    27.9134  -17.3864
            13  N5x N    26.6971  -16.6840
            14  X   Cl   19.3984  -19.4932
            15  C1b C    24.2641  -15.2794
            16  C1b C    25.4827  -14.5758
            17  N1c N    25.4827  -13.1727
            18  C1a C    26.6827  -12.4797
            19  C1a C    24.2497  -12.4607
            20  C6a C    33.4389  -15.9340
            21  C2b C    32.7702  -14.7804
            22  O6a O    32.8450  -17.1623
            23  O6a O    34.7766  -15.9277
            24  C2b C    31.1688  -14.7865
            25  C6a C    30.5061  -15.9461
            26  O6a O    29.1684  -15.9461
            27  O6a O    31.1811  -17.1684
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    2  14 1
            16    9  15 1 #Down
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1
            21   20  21 1
            22   20  22 1
            23   20  23 2
            24   21  24 2
            25   24  25 1
            26   25  26 1
            27   25  27 2

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