KEGG   DRUG: Donepezil hydrochlorideHelp
Entry
D00670                      Drug                                   

Name
Donepezil hydrochloride (JP17/USAN);
Aricept (TN)
Product
  Generic
DONEPEZIL HYDROCHLORIDE (AvKARE), DONEPEZIL HYDROCHLORIDE (Camber Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (INDICUS PHARMA LLC), DONEPEZIL HYDROCHLORIDE (A-S Medication Solutions), DONEPEZIL HYDROCHLORIDE (Actavis Pharma), DONEPEZIL HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), DONEPEZIL HYDROCHLORIDE (Alembic Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Alembic Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Alembic Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (American Health Packaging), DONEPEZIL HYDROCHLORIDE (American Health Packaging), DONEPEZIL HYDROCHLORIDE (Aurobindo Pharma Limited), DONEPEZIL HYDROCHLORIDE (AvKARE), DONEPEZIL HYDROCHLORIDE (BIOMES PHARMACEUTICALS LLC), DONEPEZIL HYDROCHLORIDE (Bi-Coastal Pharma International LLC), DONEPEZIL HYDROCHLORIDE (Bionpharma), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Cadila Healthcare Limited), DONEPEZIL HYDROCHLORIDE (Cadila Healthcare Limited), DONEPEZIL (Camber Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Cardinal Health), DONEPEZIL HYDROCHLORIDE (Cardinal Health), DONEPEZIL HYDROCHLORIDE (Cardinal Health), DONEPEZIL HYDROCHLORIDE (Cardinal Health), DONEPEZIL HYDROCHLORIDE (Cardinal Health), DONEPEZIL HYDROCHLORIDE (Carilion Materials Management), DONEPEZIL HYDROCHLORIDE (Citron Pharma LLC), DONEPEZIL HYDROCHLORIDE (Contract Pharmacy Services-PA), DONEPEZIL HYDROCHLORIDE (Dexcel Pharma Technologies), DONEPEZIL HYDROCHLORIDE (Dr. Reddys Laboratories Limited), DONEPEZIL HYDROCHLORIDE (Dr. Reddys Laboratories Limited), DONEPEZIL HYDROCHLORIDE (Golden State Medical Supply), DONEPEZIL HYDROCHLORIDE (Hikma Pharmaceutical), DONEPEZIL HYDROCHLORIDE (Jubilant Cadista Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), DONEPEZIL HYDROCHLORIDE (LUCID PHARMA LLC), DONEPEZIL HYDROCHLORIDE (Lupin Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Macleods Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Macleods Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Macleods Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Major Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Major Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (McKesson Contract Packaging), DONEPEZIL HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), DONEPEZIL HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), DONEPEZIL HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), DONEPEZIL HYDROCHLORIDE (Mylan Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Mylan Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (NCS HealthCare of KY), DONEPEZIL HYDROCHLORIDE (NCS HealthCare of KY), DONEPEZIL HYDROCHLORIDE (NCS HealthCare of KY), DONEPEZIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Par Pharmaceutical), DONEPEZIL HYDROCHLORIDE (Physicians Total Care), DONEPEZIL HYDROCHLORIDE (Proficient Rx LP), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (Ranbaxy Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Rebel Distributors Corp), DONEPEZIL HYDROCHLORIDE (Sandoz), DONEPEZIL HYDROCHLORIDE (Sandoz), DONEPEZIL HYDROCHLORIDE (ScieGen Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Solco Healthcare US), DONEPEZIL HYDROCHLORIDE (St Marys Medical Park Pharmacy), DONEPEZIL HYDROCHLORIDE (Sun Pharmaceutical Industries Limited), DONEPEZIL HYDROCHLORIDE (TWi Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Torrent Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), DONEPEZIL HYDROCHLORIDE (Unit Dose Services), DONEPEZIL HYDROCHLORIDE (Unit Dose Services), DONEPEZIL HYDROCHLORIDE (Unit Dose Services), DONEPEZIL HYDROCHLORIDE (Vensun Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (West-ward Pharmaceutical Corp), DONEPEZIL HYDROCHLORIDE (Wockhardt Limited), DONEPEZIL HYDROCHLORIDE (Wockhardt USA LLC.), DONEPEZIL HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), DONEPEZIL HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C24H29NO3. HCl
Exact mass
415.1914
Mol weight
415.9529
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Unclassified
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Nootropic, Acetylcholinesterase inhibitor
  Disease
Alzheimer's disease [DS:H00056]
Target
ACHE [HSA:43] [KO:K01049]
  Pathway
Glycerophospholipid metabolism
Cholinergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA02 Donepezil
      D00670  Donepezil hydrochloride (JP17/USAN)
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Donepezil
    D00670  Donepezil hydrochloride (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D00670  Donepezil hydrochloride (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Donepezil
     D00670  Donepezil hydrochloride (JP17/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Donepezil
    D00670  Donepezil hydrochloride (JP17/USAN)
  CYP3A4
   Donepezil
    D00670  Donepezil hydrochloride (JP17/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00670  Donepezil hydrochloride
  D00670  Donepezil hydrochloride tablets
  D00670  Donepezil hydrochloride fine granules
Neurological agents [br08367.html]
 Anti-Alzheimer agents
  D00670
BRITE hierarchy
Other DBs
CAS: 
120011-70-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   X   Cl   25.2087  -22.5699
            2   C8y C    24.0800  -25.5500
            3   C8x C    24.0800  -26.9500
            4   C8x C    25.2924  -27.6500
            5   C8x C    26.5049  -26.9500
            6   C8x C    26.5049  -25.5500
            7   C8x C    25.2924  -24.8500
            8   C1b C    22.8676  -24.8500
            9   N1y N    21.6721  -25.5404
            10  C1x C    20.4847  -24.8549
            11  C1x C    19.2723  -25.5550
            12  C1y C    19.2724  -26.9550
            13  C1x C    20.4597  -27.6404
            14  C1x C    21.6721  -26.9404
            15  C1b C    18.0455  -27.6636
            16  C1y C    16.8381  -26.9666
            17  C5x C    16.8881  -25.5501
            18  C8y C    15.5615  -25.0643
            19  C8y C    14.6895  -26.1759
            20  C1x C    15.4772  -27.3487
            21  O5x O    18.0372  -24.7769
            22  C8x C    15.0396  -23.7652
            23  C8y C    13.6536  -23.5677
            24  C8y C    12.7816  -24.6793
            25  C8x C    13.3035  -25.9784
            26  O2a O    13.1387  -22.2867
            27  C1a C    11.7702  -22.2314
            28  O2a O    11.4279  -24.6970
            29  C1a C    10.7132  -23.4957
BOND        31
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15   12  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   16  20 1
            22   17  21 2
            23   18  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   19  25 2
            28   23  26 1
            29   26  27 1
            30   24  28 1
            31   28  29 1

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