KEGG   DRUG: D00670Help
Entry
D00670                      Drug                                   

Name
Donepezil hydrochloride (JP16/USAN);
Aricept (TN)
Product
  Generic
DONEPEZIL HYDROCHLORIDE (INDICUS PHARMA LLC), DONEPEZIL HYDROCHLORIDE (ALVOGEN), DONEPEZIL HYDROCHLORIDE (Accord Healthcare), DONEPEZIL HYDROCHLORIDE (Actavis), DONEPEZIL HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), DONEPEZIL HYDROCHLORIDE (American Health Packaging), DONEPEZIL HYDROCHLORIDE (Aurobindo Pharma Limited), DONEPEZIL HYDROCHLORIDE (Cadila Healthcare Limited), DONEPEZIL HYDROCHLORIDE (Cadila Healthcare Limited), DONEPEZIL HYDROCHLORIDE (Cardinal Health), DONEPEZIL HYDROCHLORIDE (Contract Pharmacy Services-PA), DONEPEZIL HYDROCHLORIDE (Dr. Reddys Laboratories Limited), DONEPEZIL HYDROCHLORIDE (Dr. Reddys Laboratories Limited), DONEPEZIL HYDROCHLORIDE (Hikma Pharmaceutical), DONEPEZIL HYDROCHLORIDE (Jubilant Cadista Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Macleods Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Macleods Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Macleods Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Major Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Major Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (McKesson Contract Packaging), DONEPEZIL HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), DONEPEZIL HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), DONEPEZIL HYDROCHLORIDE (Mylan Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (NCS HealthCare of KY), DONEPEZIL HYDROCHLORIDE (NorthStar RxLLC), DONEPEZIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Par Pharmaceutical), DONEPEZIL HYDROCHLORIDE (Physicians Total Care), DONEPEZIL HYDROCHLORIDE (Preferred Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (Ranbaxy Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Rebel Distributors Corp), DONEPEZIL HYDROCHLORIDE (Sandoz), DONEPEZIL HYDROCHLORIDE (Sandoz), DONEPEZIL HYDROCHLORIDE (Solco Healthcare US), DONEPEZIL HYDROCHLORIDE (Sun Pharmaceutical Industries Limited), DONEPEZIL HYDROCHLORIDE (Teva Pharmaceuticals USA), DONEPEZIL HYDROCHLORIDE (Torrent Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Unit Dose Services), DONEPEZIL HYDROCHLORIDE (Unit Dose Services), DONEPEZIL HYDROCHLORIDE (West-ward Pharmaceutical Corp), DONEPEZIL HYDROCHLORIDE (Wockhardt Limited), DONEPEZIL HYDROCHLORIDE (Wockhardt USA LLC.), DONEPEZIL HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), DONEPEZIL HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C24H29NO3. HCl
Exact mass
415.1914
Mol weight
415.9529
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Alzheimer's disease treatment [adjunct];
Dementia symptoms treatment adjunct;
Cognition adjuvant;
Inhibitor [acetylcholinesterase] [DS:H00056]
Remark
Therapeutic category: 
ATC code: 
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D00670  Donepezil hydrochloride (JP16/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA02 Donepezil
      D00670  Donepezil hydrochloride (JP16/USAN)
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Donepezil
    D00670  Donepezil hydrochloride (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE) [HSA:43] [KO:K01049]
    Donepezil [ATC:N06DA02]
     D00670  Donepezil hydrochloride (JP16/USAN)
BRITE hierarchy
Other DBs
CAS: 
120011-70-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   X   Cl   32.5296  -24.5080
            2   C8y C    21.6300  -22.4000
            3   C8y C    21.6300  -21.0000
            4   C8x C    22.8900  -20.3000
            5   C8y C    24.0800  -21.0000
            6   C8y C    24.0800  -22.4000
            7   C8x C    22.8900  -23.1000
            8   O2a O    20.4400  -23.1000
            9   C1a C    19.2500  -22.4000
            10  O2a O    20.4400  -20.3000
            11  C1a C    19.2500  -21.0000
            12  C5x C    25.4100  -20.5800
            13  C1y C    26.2500  -21.7000
            14  C1x C    25.4100  -22.8200
            15  O5x O    25.8300  -19.2500
            16  C1b C    27.4400  -22.4000
            17  C1y C    28.6300  -21.7000
            18  C1x C    28.6300  -20.3000
            19  C1x C    29.8900  -19.6000
            20  N1y N    31.0800  -20.3000
            21  C1x C    31.0800  -21.7000
            22  C1x C    29.8900  -22.4000
            23  C1b C    32.2700  -19.6000
            24  C8y C    33.4600  -20.3000
            25  C8x C    34.6500  -19.6000
            26  C8x C    35.9100  -20.3000
            27  C8x C    35.9100  -21.7000
            28  C8x C    34.7200  -22.4000
            29  C8x C    33.4600  -21.7000
BOND        31
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     8   9 1
            9     3  10 1
            10   10  11 1
            11    5  12 1
            12   12  13 1
            13   13  14 1
            14    6  14 1
            15   12  15 2
            16   16  17 1
            17   16  13 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   17  22 1
            24   20  23 1
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   24  29 1

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