KEGG   DRUG: D00672Help
Entry
D00672                      Drug                                   

Name
Hydroxyzine hydrochloride (JP16/USP);
Atarax (TN);
Vistaril (TN)
Product
  Generic
HYDROXYZINE HYDROCHLORIDE (Blenheim Pharmacal), HYDROXYZINE (Blenheim Pharmacal), HYDROXYZINE (Blenheim Pharmacal), HYDROXYZINE (General Injectables & Vaccines), HYDROXYZINE (General Injectables & Vaccines), HYDROXYZINE (General Injectables & Vaccines), HYDROXYZINE (General Injectables & Vaccines), HYDROXYZINE HYDROCHLORIDE (Golden State Medical Supply), HYDROXYZINE HYDROCHLORIDE (Harris Pharmaceutical), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Physicians Total Care), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions LLC), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions LLC), HYDROXYZINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), HYDROXYZINE HYDROCHLORIDE (American Health Packaging), HYDROXYZINE HYDROCHLORIDE (American Regent), HYDROXYZINE HYDROCHLORIDE (Blenheim Pharmacal), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Caraco Pharmaceutical Laboratories), HYDROXYZINE HYDROCHLORIDE (Cardinal Health), HYDROXYZINE HYDROCHLORIDE (Cardinal Health), HYDROXYZINE HYDROCHLORIDE (Cardinal Health), HYDROXYZINE HYDROCHLORIDE (Clinical Solutions Wholesale), HYDROXYZINE HYDROCHLORIDE (Dispensing Solutions), HYDROXYZINE HYDROCHLORIDE (Glenmark Generics), HYDROXYZINE HYDROCHLORIDE (H.J. Harkins Company), HYDROXYZINE HYDROCHLORIDE (Heritage Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Hi-Tech Pharmacal), HYDROXYZINE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), HYDROXYZINE HYDROCHLORIDE (KVK-Tech), HYDROXYZINE HYDROCHLORIDE (KVK-Tech), HYDROXYZINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), HYDROXYZINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), HYDROXYZINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), HYDROXYZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), HYDROXYZINE HYDROCHLORIDE (Liberty Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Life Line Home Care Services), HYDROXYZINE (Major Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (McKesson Contract Packaging), HYDROXYZINE HYDROCHLORIDE (McKesson Packaging Services Business Unit of McKesson Corporation), HYDROXYZINE HYDROCHLORIDE (Morton Grove Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Mylan Pharmaceuticals), HYDROXYZINE (NCS HealthCare of KY), HYDROXYZINE HYDROCHLORIDE (Northstar RxLLC), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Physicians Total Care), HYDROXYZINE HYDROCHLORIDE (Physicians Total Care), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Qualitest Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Qualitest Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (Rebel Distributors Corp), HYDROXYZINE HYDROCHLORIDE (RedPharm Drug), HYDROXYZINE HYDROCHLORIDE (RedPharm Drug), HYDROXYZINE HYDROCHLORIDE (RedPharm Drug), HYDROXYZINE (Silarx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Teva Pharmaceuticals USA), HYDROXYZINE HYDROCHLORIDE (UDL Laboratories), HYDROXYZINE HYDROCHLORIDE (Watson Laboratories)
Formula
C21H27ClN2O2. 2HCl
Exact mass
446.1295
Mol weight
447.8262
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer [minor]
Remark
Therapeutic category: 
ATC code: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Anxiolytics
Hypnotics
Histamine H1 receptor antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00672  Hydroxyzine hydrochloride (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BB Diphenylmethane derivatives
     N05BB01 Hydroxyzine
      D00672  Hydroxyzine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Hydroxyzine
    D00672  Hydroxyzine hydrochloride (JP16/USP)
 Anxiolytics
  Anxiolytics, Other
   Hydroxyzine
    D00672  Hydroxyzine hydrochloride (JP16/USP)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Hydroxyzine
    D00672  Hydroxyzine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Hydroxyzine [ATC:N05BB01]
      D00672  Hydroxyzine hydrochloride (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
2192-20-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8x C     8.6800  -18.1300
            2   C8y C     8.6800  -19.5300
            3   C8x C     9.8924  -20.2300
            4   C8x C    11.1049  -19.5300
            5   C8y C    11.1049  -18.1300
            6   C8x C     9.8924  -17.4300
            7   C8x C    13.5297  -19.5300
            8   C8y C    13.5297  -18.1300
            9   C1c C    12.3173  -17.4300
            10  N1y N    12.3173  -16.0300
            11  C1x C    13.5318  -15.3288
            12  C1x C    13.5318  -13.9288
            13  N1y N    12.3193  -13.2288
            14  C1x C    11.1049  -13.9300
            15  C1x C    11.1049  -15.3300
            16  C8x C    14.7422  -20.2300
            17  C8x C    15.9546  -19.5300
            18  C8x C    15.9546  -18.1300
            19  C8x C    14.7422  -17.4300
            20  X   Cl    7.4676  -20.2300
            21  C1b C    12.3193  -11.8300
            22  C1b C    13.5323  -11.1297
            23  O2a O    14.7280  -11.8202
            24  C1b C    15.9152  -11.1349
            25  C1b C    17.1065  -11.8229
            26  O1a O    18.2960  -11.1362
            27  X   Cl   17.8500  -15.4000
            28  X   Cl   17.8500  -15.4000
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   10  15 1
            17    7  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21    8  19 2
            22    2  20 1
            23   13  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
BRACKET     1    16.2400  -16.2400   16.2400  -14.6300
            1    18.6900  -14.6300   18.6900  -16.2400
            1  2
 ORIGINAL  1   27
 REPEAT    1   28

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