KEGG   DRUG: D00674Help
Entry
D00674                      Drug                                   

Name
Naratriptan hydrochloride (JAN/USAN);
Amerge (TN)
Product
  Generic
Formula
C17H25N3O2S. HCl
Exact mass
371.1434
Mol weight
371.9252
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antimigraine
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
5-HT1A-receptor agonist [HSA:3350] [KO:K04153];
5-HT1B-receptor agonist [HSA:3351] [KO:K04153];
5-HT1D-receptor agonist [HSA:3352] [KO:K04153];
5-HT1E-receptor agonist [HSA:3354] [KO:K04153];
5-HT1F-receptor agonist [HSA:3355] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C9 [HSA:1559], CYP2D6 [HSA:1565], CYP2E1 [HSA:1571], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Drug interaction
Structure map
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC02 Naratriptan
      D00674  Naratriptan hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Antimigraine Agents
  Serotonin (5-HT) 1b/1d Receptor Agonists
   Naratriptan
    D00674  Naratriptan hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00674  Naratriptan hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1A-receptor
     Naratriptan
      D00674  Naratriptan hydrochloride (JAN/USAN)
    5-HT1B-receptor
     Naratriptan
      D00674  Naratriptan hydrochloride (JAN/USAN)
    5-HT1D-receptor
     Naratriptan
      D00674  Naratriptan hydrochloride (JAN/USAN)
    5-HT1E-receptor
     Naratriptan
      D00674  Naratriptan hydrochloride (JAN/USAN)
    5-HT1F-receptor
     Naratriptan
      D00674  Naratriptan hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Naratriptan
    D00674  Naratriptan hydrochloride (JAN/USAN)
  CYP2C9
   Naratriptan
    D00674  Naratriptan hydrochloride (JAN/USAN)
  CYP2D6
   Naratriptan
    D00674  Naratriptan hydrochloride (JAN/USAN)
  CYP3A4
   Naratriptan
    D00674  Naratriptan hydrochloride (JAN/USAN)
  CYP3A5
   Naratriptan
    D00674  Naratriptan hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
143388-64-1
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        24
            1   C8y C    33.6700  -19.1800
            2   C8y C    35.0000  -18.6900
            3   C8y C    33.6700  -20.5800
            4   C8x C    32.4100  -18.4800
            5   C8x C    35.8400  -19.8800
            6   N4x N    35.0000  -21.0000
            7   C8x C    32.4100  -21.2800
            8   C8y C    31.2200  -19.1800
            9   C8x C    31.2200  -20.5800
            10  C1b C    30.0300  -18.4800
            11  C1b C    28.8400  -19.1800
            12  S4a S    27.5800  -18.4800
            13  N1b N    26.3900  -19.1800
            14  O3c O    28.8400  -17.7800
            15  O3c O    26.3900  -17.7800
            16  C1a C    25.2000  -18.4800
            17  C1y C    35.0000  -17.2900
            18  C1x C    36.1900  -16.5900
            19  C1x C    36.1900  -15.1900
            20  N1y N    35.0000  -14.4900
            21  C1x C    33.8100  -15.1900
            22  C1x C    33.8100  -16.5900
            23  C1a C    35.0000  -13.0900
            24  X   Cl   38.9900  -19.8800
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     7   9 2
            9     8  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   12  14 2
            14   12  15 2
            15   13  16 1
            16    5   6 1
            17    8   9 1
            18    2  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   17  22 1
            25   20  23 1

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