KEGG   DRUG: Rizatriptan benzoateHelp
Entry
D00675                      Drug                                   

Name
Rizatriptan benzoate (JAN/USAN);
Maxalt (TN)
Product
  Generic
RIZATRIPTAN (Macleods Pharmaceuticals Limited), RIZATRIPTAN (Preferred Pharmaceuticals), RIZATRIPTAN (REMEDYREPACK), RIZATRIPTAN BENZOATE (A-S Medication Solutions), RIZATRIPTAN BENZOATE (A-S Medication Solutions), RIZATRIPTAN BENZOATE (A-S Medication Solutions), RIZATRIPTAN BENZOATE (Apotex Corp), RIZATRIPTAN BENZOATE (Apotex Corp), RIZATRIPTAN BENZOATE (Ascend Laboratories), RIZATRIPTAN BENZOATE (Aurobindo Pharma Limited), RIZATRIPTAN BENZOATE (Aurobindo Pharma Limited), RIZATRIPTAN BENZOATE (Bionpharma Inc.,), RIZATRIPTAN BENZOATE (Breckenridge Pharmaceutical), RIZATRIPTAN BENZOATE (Breckenridge Pharmaceutical), RIZATRIPTAN BENZOATE (Camber Pharmaceuticals), RIZATRIPTAN BENZOATE (Cipla USA), RIZATRIPTAN BENZOATE (Cipla USA), RIZATRIPTAN BENZOATE (Citron Pharma LLC), RIZATRIPTAN BENZOATE (Citron Pharma LLC), RIZATRIPTAN BENZOATE (Glenmark Pharmaceuticals), RIZATRIPTAN BENZOATE (Glenmark Pharmaceuticals), RIZATRIPTAN BENZOATE (Heritage Pharmaceuticals), RIZATRIPTAN BENZOATE (Jubilant Cadista Pharmaceuticals), RIZATRIPTAN BENZOATE (Jubilant Cadista Pharmaceuticals), RIZATRIPTAN BENZOATE (Macleods Pharmaceuticals Limited), RIZATRIPTAN BENZOATE (Medsource Pharmaceuticals), RIZATRIPTAN BENZOATE (Mesource Pharmaceuticals), RIZATRIPTAN BENZOATE (Mylan Pharmaceuticals), RIZATRIPTAN BENZOATE (Mylan Pharmaceuticals), RIZATRIPTAN BENZOATE (Par Pharmaceutical), RIZATRIPTAN BENZOATE (Physicians Total Care), RIZATRIPTAN BENZOATE (Physicians Total Care), RIZATRIPTAN BENZOATE (Preferred Pharmaceuuticals), RIZATRIPTAN BENZOATE (Proficient Rx LP), RIZATRIPTAN BENZOATE (Sandoz), RIZATRIPTAN BENZOATE (Sandoz), RIZATRIPTAN BENZOATE (Teva Pharmaceuticals USA), RIZATRIPTAN BENZOATE (Unichem Pharmaceuticals (USA)), RIZATRIPTAN BENZOATE (Unichem Pharmaceuticals (USA))
Formula
C15H19N5. C7H6O2
Exact mass
391.2008
Mol weight
391.4662
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Analgesic
 DG01484  5-HT1B-receptor agonist
 DG01485  5-HT1D-receptor agonist
 DG01518  5-HT1B/1D-receptor agonist
 DG01943  Triptan
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antimigraine, Vasoconstrictor, Serotonin receptor agonist
Comment
Sumatriptan derivative
Target
HTR1B [HSA:3351] [KO:K04153];
HTR1D [HSA:3352] [KO:K04153]
  Pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
Metabolism
Enzyme: MAOA [HSA:4128]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC04 Rizatriptan
      D00675  Rizatriptan benzoate (JAN/USAN)
USP drug classification [BR:br08302]
 Antimigraine Agents
  Serotonin (5-HT) 1b/1d Receptor Agonists
   Rizatriptan
    D00675  Rizatriptan benzoate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00675  Rizatriptan benzoate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1B-receptor
     Rizatriptan
      D00675  Rizatriptan benzoate (JAN/USAN)
    5-HT1D-receptor
     Rizatriptan
      D00675  Rizatriptan benzoate (JAN/USAN)
Anesthetics, analgesics and anti-inflammatory drugs [br08369.html]
 Therapeutic / prophylactic agents for migraine
  D00675
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00675
BRITE hierarchy
Other DBs
CAS: 
145202-66-0
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C8y C    30.1421  -18.0733
            2   C8y C    30.1421  -19.4722
            3   C8y C    31.4714  -17.6437
            4   C8x C    28.9347  -17.3768
            5   N4x N    31.4714  -19.9075
            6   C8x C    28.9347  -20.1687
            7   C8x C    32.2898  -18.7699
            8   C8y C    27.7215  -18.0733
            9   C8x C    27.7215  -19.4663
            10  C1b C    26.5030  -17.3679
            11  N4y N    25.3135  -18.0529
            12  N5x N    25.3135  -19.4529
            13  C8x C    23.9820  -17.6203
            14  N5x N    23.1591  -18.7529
            15  C8x C    23.9820  -19.8856
            16  C1b C    31.4714  -16.2437
            17  C1b C    32.7068  -15.5303
            18  N1c N    33.9108  -16.2253
            19  C1a C    35.0937  -15.5422
            20  C1a C    33.9113  -17.6397
            21  C8y C    39.2467  -17.9866
            22  C8x C    38.0392  -18.6832
            23  C8x C    40.4483  -18.6832
            24  C6a C    39.2467  -16.5994
            25  C8x C    38.0392  -20.0706
            26  C8x C    40.4483  -20.0706
            27  O6a O    40.4540  -15.9028
            28  O6a O    38.0451  -15.9028
            29  C8x C    39.2467  -20.7613
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     6   9 1
            9     5   7 1
            10    8   9 2
            11    8  10 1
            12   10  11 1
            13   11  12 1
            14   11  13 1
            15   13  14 2
            16   14  15 1
            17   12  15 2
            18    3  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 1
            23   21  22 1
            24   21  23 2
            25   21  24 1
            26   22  25 2
            27   23  26 1
            28   24  27 1
            29   24  28 2
            30   25  29 1
            31   26  29 2

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