KEGG   DRUG: D00676Help
Entry
D00676                      Drug                                   

Name
Sumatriptan succinate (JAN/USAN);
Alsuma (TN);
Imitrex (TN);
Sumave dosepro (TN);
Zecutity (TN)
Product
  Generic
SUMATRIPTAN (AGILA SPECIALTIES PRIVATE LIMITED), SUMATRIPTAN SUCCINATE (APP Pharmaceuticals), SUMATRIPTAN (Northstar Rx LLC), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN (Ranbaxy Pharmaceuticals), SUMATRIPTAN (Unit Dose Services), SUMATRIPTAN (Unit Dose Services), SUMATRIPTAN SUCCINATE (American Health Packaging), SUMATRIPTAN SUCCINATE (Aurobindo Pharma Limited), SUMATRIPTAN SUCCINATE (Cobalt Laboratories), SUMATRIPTAN SUCCINATE (Dispensing Solutions), SUMATRIPTAN SUCCINATE (Dr. Reddy's Laboratories Limited), SUMATRIPTAN SUCCINATE (Dr. Reddy's Laboratories Limited), SUMATRIPTAN (Greenstone LLC), SUMATRIPTAN SUCCINATE (H.J. Harkins Company), SUMATRIPTAN SUCCINATE (JHP Pharmaceuticals LLC), SUMATRIPTAN SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), SUMATRIPTAN SUCCINATE (MedVantx), SUMATRIPTAN SUCCINATE (Mylan Pharmaceuticals), SUMATRIPTAN SUCCINATE (Preferred Pharmaceuticals), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN (REMEDYREPACK), SUMATRIPTAN (REMEDYREPACK), SUMATRIPTAN SUCCINATE (REMEDYREPACK), SUMATRIPTAN SUCCINATE (Rebel Distributors Corp), SUMATRIPTAN SUCCINATE (Rebel Distributors Corp), SUMATRIPTAN SUCCINATE (STAT Rx USA LLC), SUMATRIPTAN SUCCINATE (SUN PHARMACEUTICAL INDUSTRIES LIMITED), SUMATRIPTAN SUCCINATE (Sagent Pharmaceuticals), SUMATRIPTAN SUCCINATE (Sagent Pharmaceuticals), SUMATRIPTAN SUCCINATE (Sun Pharma Global FZE), SUMATRIPTAN SUCCINATE (Teva Parenteral Medicines), SUMATRIPTAN SUCCINATE (Unit Dose Services), SUMATRIPTAN (West-Ward Pharmaceutical Corp), SUMATRIPTAN SUCCINATE (Wockhardt Limited), SUMATRIPTAN SUCCINATE (Wockhardt USA LLC.)
Formula
C14H21N3O2S. C4H6O4
Exact mass
413.1621
Mol weight
413.4885
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antimigraine
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Triptans
Target
5-HT1B-receptor agonist [HSA:3351] [KO:K04153];
5-HT1D-receptor agonist [HSA:3352] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: MAOA [HSA:4128]
Interaction
Drug interaction
Structure map
Antimigraines
Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC01 Sumatriptan
      D00676  Sumatriptan succinate (JAN/USAN)
USP drug classification [BR:br08302]
 Antimigraine Agents
  Serotonin (5-HT) 1b/1d Receptor Agonists
   Sumatriptan
    D00676  Sumatriptan succinate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00676  Sumatriptan succinate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1B-receptor
     Sumatriptan
      D00676  Sumatriptan succinate (JAN/USAN)
    5-HT1D-receptor
     Sumatriptan
      D00676  Sumatriptan succinate (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
103628-48-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    23.6794  -17.9951
            2   C8y C    23.6853  -19.3996
            3   C8y C    25.0140  -17.5639
            4   C8x C    22.4731  -17.2843
            5   N4x N    25.0197  -19.8250
            6   C8x C    22.4673  -20.0930
            7   C8x C    25.8357  -18.6886
            8   C1b C    25.3287  -16.1944
            9   C8y C    21.2553  -17.9893
            10  C8x C    21.2610  -19.3937
            11  C1b C    26.6633  -15.7807
            12  C1b C    20.0373  -17.2957
            13  N1c N    26.9720  -14.4170
            14  S4a S    18.8310  -18.0010
            15  C1a C    28.3066  -14.0033
            16  C1a C    25.9464  -13.4671
            17  N1b N    17.6247  -17.3017
            18  O3c O    19.8217  -19.0033
            19  O3c O    17.8344  -19.0033
            20  C1a C    16.4124  -18.0067
            21  C1b C    30.7583  -18.8477
            22  C1b C    31.9646  -18.1484
            23  C6a C    29.5461  -18.1543
            24  C6a C    33.1767  -18.8420
            25  O6a O    28.3397  -18.8536
            26  O6a O    29.5461  -16.7557
            27  O6a O    34.3889  -18.1426
            28  O6a O    33.1767  -20.2406
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    8  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 2
            18   14  19 2
            19   17  20 1
            20    5   7 1
            21    9  10 2
            22   21  22 1
            23   21  23 1
            24   22  24 1
            25   23  25 1
            26   23  26 2
            27   24  27 1
            28   24  28 2

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