KEGG   DRUG: Granisetron hydrochlorideHelp
Entry
D00677                      Drug                                   

Name
Granisetron hydrochloride (JAN/USAN);
Kytril (TN)
Product
  Generic
GRANISETRON (Sandoz), GRANISETRON HYDROCHLORIDE (Akorn), GRANISETRON HYDROCHLORIDE (Ascend Laboratories), GRANISETRON HYDROCHLORIDE (AuroMedics Pharma LLC), GRANISETRON HYDROCHLORIDE (Avera McKennan Hospital), GRANISETRON HYDROCHLORIDE (Breckenridge Pharmaceutical), GRANISETRON HYDROCHLORIDE (Cipla Limited), GRANISETRON HYDROCHLORIDE (Cipla USA), GRANISETRON (Fresenius Kabi USA), GRANISETRON HYDROCHLORIDE (Northstar Rx LLC), GRANISETRON HYDROCHLORIDE (Northstar Rx LLC), GRANISETRON HYDROCHLORIDE (OrchidPharma), GRANISETRON HYDROCHLORIDE (Sagent Pharmaceuticals), GRANISETRON HYDROCHLORIDE (Sagent Pharmaceuticals), GRANISETRON HYDROCHLORIDE (Sagent Pharmaceuticals), GRANISETRON HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), GRANISETRON HYDROCHLORIDE (Teva Pharmaceuticals USA), GRANISETRON HYDROCHLORIDE (WOCKHARDT LIMITED), GRANISETRON HYDROCHLORIDE (WOCKHARDT LIMITED), GRANISETRON HYDROCHLORIDE (WOCKHARDT LIMITED), GRANISETRON HYDROCHLORIDE (WOCKHARDT USA LLC), GRANISETRON HYDROCHLORIDE (WOCKHARDT USA LLC), GRANISETRON HYDROCHLORIDE (WOCKHARDT USA LLC), GRANISETRON HYDROCHLORIDE (West-Ward Pharmaceutical Corp), GRANISETRON HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.)
Formula
C18H24N4O. HCl
Exact mass
348.1717
Mol weight
348.8703
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Gastrointestinal agent
 DG01762  Antiemetic
Other
 DG01489  5-HT3-receptor antagonist
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Anti-emetic, 5-HT3 receptor antagonist
Target
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Structure map
Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA02 Granisetron
      D00677  Granisetron hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Granisetron
    D00677  Granisetron hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D00677  Granisetron hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT3-receptor
     Granisetron
      D00677  Granisetron hydrochloride (JAN/USAN)
Gastrointestinal agents [br08371.html]
 Antiemetic
  D00677
BRITE hierarchy
Other DBs
CAS: 
107007-99-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   X   Cl   38.4938  -15.6255
            2   C1x C    25.8300  -15.8200
            3   C1x C    25.9700  -14.9100
            4   C1y C    26.9500  -15.5400
            5   C1y C    27.2300  -14.4200
            6   N1y N    26.0400  -13.1600
            7   C1x C    28.7000  -15.5400
            8   C1x C    28.4200  -14.4200
            9   C1y C    29.6800  -16.0300
            10  N1b N    30.7300  -16.9400
            11  C5a C    31.8500  -16.9400
            12  C8y C    32.4100  -15.8900
            13  O5a O    32.4100  -17.9900
            14  C1a C    25.3400  -12.0400
            15  C1x C    24.8500  -14.4200
            16  C8y C    33.7400  -15.8900
            17  C8y C    34.1600  -14.6300
            18  N4y N    33.1100  -13.8600
            19  N5x N    31.9900  -14.6300
            20  C8x C    34.6500  -16.8700
            21  C8x C    35.9100  -16.5900
            22  C8x C    36.3300  -15.3300
            23  C8x C    35.4200  -14.3500
            24  C1a C    33.1100  -12.5300
BOND        26
            1     2   4 1
            2     3   5 1
            3     4   6 1
            4     4   7 1
            5     5   8 1
            6     7   9 1
            7     9  10 1
            8    10  11 1
            9    11  12 1
            10   11  13 2
            11    5   6 1
            12    8   9 1
            13    6  14 1
            14    3  15 1
            15    2  15 1
            16   12  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   12  19 2
            21   16  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   17  23 2
            26   18  24 1

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