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Entry
D00678                      Drug                                   

Name
Ondansetron hydrochloride hydrate (JAN/USP);
Ondansetron hydrochloride;
Zofran (TN)
Product
  Generic
ONDANSETRON (Actavis), ONDANSETRON (Amneal Pharmaceuticals of New York), ONDANSETRON (Atlantic Biologicals Corps), ONDANSETRON (Atlantic Biologicals Corps), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Clinical Solutions Wholesale), ONDANSETRON (DIRECT RX), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Life Line Home Care Services), ONDANSETRON (Mylan Institutional), ONDANSETRON (Mylan Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (Pfizer Laboratories Div Pfizer), ONDANSETRON (Pfizer Laboratories Div Pfizer), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Proficient Rx LP), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (Ranbaxy Pharmaceuticals), ONDANSETRON (STAT Rx USA LLC), ONDANSETRON (Sandoz), ONDANSETRON (Sandoz), ONDANSETRON (Sandoz), ONDANSETRON (Teva Parenteral Medicines), ONDANSETRON (Teva Parenteral Medicines), ONDANSETRON (West-Ward Pharmaceutical Corp.), ONDANSETRON (West-Ward Pharmaceutical Corp.), ONDANSETRON HCL (Northwind Pharmaceuticals), ONDANSETRON (APP Pharmaceuticals), ONDANSETRON (APP Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), ONDANSETRON HYDROCHLORIDE (American Health Packaging), ONDANSETRON (Apotex Corp), ONDANSETRON HYDROCHLORIDE (Ascend Laboratories), ONDANSETRON (AuroMedics Pharma LLC), ONDANSETRON (AuroMedics Pharma LLC), ONDANSETRON HYDROCHLORIDE (Aurobindo Pharma Limited), ONDANSETRON (Aurobindo Pharma Limited), ONDANSETRON (BD Rx), ONDANSETRON (Baxter Healthcare Corporation), ONDANSETRON (Baxter Healthcare Corporation), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Cardinal Health), ONDANSETRON HYDROCHLORIDE (Cardinal Health), ONDANSETRON HYDROCHLORIDE (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON HYDROCHLORIDE (Claris Lifesciences), ONDANSETRON HYDROCHLORIDE (Dispensing Solutions), ONDANSETRON HYDROCHLORIDE (Dispensing Solutions), ONDANSETRON HYDROCHLORIDE (Dr.Reddy's Laboratories Limited), ONDANSETRON HYDROCHLORIDE (H.J. Harkins Company), ONDANSETRON HYDROCHLORIDE (Heritage Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Heritage Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Heritage Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Heritage Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Hospira), ONDANSETRON (Hospira), ONDANSETRON (Hospira), ONDANSETRON HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), ONDANSETRON HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Lannett Company), ONDANSETRON (Major Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (MedVantx), ONDANSETRON (NorthStar Rx LLC), ONDANSETRON HYDROCHLORIDE (Pfizer Laboratories Div Pfizer), ONDANSETRON HYDROCHLORIDE (Pfizer Laboratories Div Pfizer), ONDANSETRON HYDROCHLORIDE (Physicians Total Care), ONDANSETRON (Physicians Total Care), ONDANSETRON HYDROCHLORIDE (Precision Dose), ONDANSETRON HYDROCHLORIDE (Preferred Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Preferred Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (Rebel Distributors Corp), ONDANSETRON HYDROCHLORIDE (Roxane Laboratories), ONDANSETRON HYDROCHLORIDE (Sagent Pharmaceuticals), ONDANSETRON (Silarx Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Sun Pharmaceutical Industries Limited), ONDANSETRON HYDROCHLORIDE (Sun Pharmaceutical Industries Limited), ONDANSETRON HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), ONDANSETRON (Taro Pharmaceuticals U.S.A.), ONDANSETRON HYDROCHLORIDE (Teva Pharmaceuticals USA), ONDANSETRON (The Medicines Company), ONDANSETRON HYDROCHLORIDE (Unit Dose Services), ONDANSETRON HYDROCHLORIDE (Unit Dose Services), ONDANSETRON HYDROCHLORIDE (WOCKHARDT LIMITED), ONDANSETRON HYDROCHLORIDE (WOCKHARDT USA LLC), ONDANSETRON (West-Ward Pharmaceutical Corp), ONDANSETRON (West-ward Pharmaceutical Corp), ONDANSETRON HYDROCHLORIDE AND DEXTROSE (Claris Lifesciences), ONDANSETRON HYDROCHLORIDE AND DEXTROSE (Pfizer Labs), ONDANSETRON HYDROCHLORIDE AND DEXTROSE (West-ward Pharmaceutical Corp)
Formula
C18H19N3O. 2H2O. HCl
Exact mass
365.1506
Mol weight
365.8545
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-anxiety agent;
Anti-emetic;
Antischizophrenic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
5-HT3-receptor antagonist [HSA:3359 9177 170572 200909 285242] [KO:K04819]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA01 Ondansetron
      D00678  Ondansetron hydrochloride hydrate (JAN/USP)
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Ondansetron
    D00678  Ondansetron hydrochloride hydrate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D00678  Ondansetron hydrochloride hydrate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT3-receptor
     Ondansetron
      D00678  Ondansetron hydrochloride hydrate (JAN/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Ondansetron
    D00678  Ondansetron hydrochloride hydrate (JAN/USP)
  CYP2D6
   Ondansetron
    D00678  Ondansetron hydrochloride hydrate (JAN/USP)
  CYP3A4
   Ondansetron
    D00678  Ondansetron hydrochloride hydrate (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
103639-04-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    27.9300   -8.4700
            2   C8y C    29.2600   -8.9600
            3   C8y C    27.9300   -7.0700
            4   C5x C    26.7400   -9.1700
            5   C8y C    30.0300   -7.7700
            6   C8x C    29.8200  -10.2200
            7   N4y N    29.2600   -6.6500
            8   C1x C    26.7400   -6.3700
            9   C1y C    25.4800   -8.4700
            10  O5x O    26.7400  -10.5700
            11  C8x C    31.4300   -7.9100
            12  C8x C    31.2200  -10.3600
            13  C1a C    29.6800   -5.3200
            14  C1x C    25.4800   -7.0700
            15  C1b C    24.2900   -9.1700
            16  C8x C    32.0600   -9.2400
            17  N4y N    23.1000   -8.4700
            18  C8y C    23.1000   -7.0700
            19  C8x C    21.7000   -8.8900
            20  N5x N    21.7700   -6.5800
            21  C1a C    24.2900   -6.3000
            22  C8x C    20.9300   -7.7000
            23  X   Cl   34.7900   -6.5800
            24  O0  O    35.4900   -8.5400
            25  O0  O    35.4900   -8.5400
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 1
            16   15  17 1
            17   17  18 1
            18   17  19 1
            19   18  20 2
            20   18  21 1
            21   19  22 2
            22    5   7 1
            23    9  14 1
            24   12  16 2
            25   20  22 1
BRACKET     1    33.3200   -9.3800   33.3200   -7.7700
            1    35.9800   -7.7700   35.9800   -9.3800
            1  2
 ORIGINAL  1   24
 REPEAT    1   25

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