KEGG   DRUG: D00685Help
Entry
D00685                      Drug                                   

Name
Orciprenaline sulfate (JP16);
Metaproterenol sulfate (USP);
Alupent (TN)
Product
  Generic
Formula
(C11H17NO3)2. H2SO4
Exact mass
520.2091
Mol weight
520.5936
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Bronchodilator [DS:H00079]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AB Non-selective beta-adrenoreceptor agonists
     R03AB03 Orciprenaline
      D00685  Orciprenaline sulfate (JP16); Metaproterenol sulfate (USP)
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CB Non-selective beta-adrenoreceptor agonists
     R03CB03 Orciprenaline
      D00685  Orciprenaline sulfate (JP16); Metaproterenol sulfate (USP)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Metaproterenol
    D00685  Orciprenaline sulfate (JP16); Metaproterenol sulfate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2252  Isoprenalines
     D00685  Orciprenaline sulfate (JP16); Metaproterenol sulfate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta2-adrenergic receptor
     Orciprenaline
      D00685  Orciprenaline sulfate (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00685  Orciprenaline sulfate
BRITE hierarchy
Other DBs
CAS: 
5874-97-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   C8y C    22.0811  -19.6871
            2   C8x C    20.8691  -20.3923
            3   C8x C    22.0811  -18.2886
            4   C1c C    23.2933  -20.3923
            5   C8y C    19.6511  -19.6871
            6   C8y C    20.8691  -17.5893
            7   C1b C    24.5113  -19.6871
            8   O1a O    23.2991  -21.7909
            9   C8x C    19.6511  -18.2886
            10  O1a O    18.4448  -20.3923
            11  O1a O    20.8691  -16.1848
            12  N1b N    25.7233  -20.3864
            13  C1c C    26.9355  -19.6813
            14  C1a C    28.1476  -20.3864
            15  C1a C    26.9355  -18.2827
            16  S4a S    33.8138  -18.9878
            17  O1d O    32.4211  -18.9820
            18  O1d O    35.2125  -18.9878
            19  O1d O    33.8081  -17.5951
            20  O1d O    33.8081  -20.3806
            21  C8y C    22.0811  -19.6871
            22  C8x C    20.8691  -20.3923
            23  C8y C    19.6511  -19.6871
            24  C8x C    19.6511  -18.2886
            25  C8y C    20.8691  -17.5893
            26  C8x C    22.0811  -18.2886
            27  O1a O    20.8691  -16.1848
            28  O1a O    18.4448  -20.3923
            29  C1c C    23.2933  -20.3923
            30  C1b C    24.5113  -19.6871
            31  N1b N    25.7233  -20.3864
            32  C1c C    26.9355  -19.6813
            33  C1a C    28.1476  -20.3864
            34  C1a C    26.9355  -18.2827
            35  O1a O    23.2991  -21.7909
BOND        34
            1    16  17 1
            2    16  18 1
            3    16  19 2
            4    16  20 2
            5     1   2 2
            6     1   3 1
            7     1   4 1
            8     2   5 1
            9     3   6 2
            10    4   7 1
            11    4   8 1
            12    5   9 2
            13    5  10 1
            14    6  11 1
            15    7  12 1
            16   12  13 1
            17   13  14 1
            18   13  15 1
            19    6   9 1
            20   21  22 2
            21   21  26 1
            22   21  29 1
            23   22  23 1
            24   26  25 2
            25   29  30 1
            26   29  35 1
            27   23  24 2
            28   23  28 1
            29   25  27 1
            30   30  31 1
            31   31  32 1
            32   32  33 1
            33   32  34 1
            34   25  24 1
BRACKET     1    17.1500  -22.8200   17.1500  -15.1200
            1    29.6100  -15.1200   29.6100  -22.8200
            1  2
 ORIGINAL  1    1   2   5   9   6   3  11  10   4   7  12  13  14  15   8
 REPEAT    1   21  22  23  24  25  26  27  28  29  30  31  32  33  34  35

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