KEGG   DRUG: D00694Help
Entry
D00694                      Drug                                   

Name
Clorazepate dipotassium (JP16/USP);
Tranxene (TN)
Product
  Generic
Formula
C16H10ClN2O3. KOH. K
Exact mass
407.9681
Mol weight
408.9191
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer [minor]
Remark
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Interaction
Drug interaction
Structure map
Anxiolytics
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00694  Clorazepate dipotassium (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA05 Potassium clorazepate
      D00694  Clorazepate dipotassium (JP16/USP)
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Clorazepate
    D00694  Clorazepate dipotassium (JP16/USP)
 Anxiolytics
  Benzodiazepines
   Clorazepate
    D00694  Clorazepate dipotassium (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Potassium clorazepate [ATC:N05BA05]
      D00694  Clorazepate dipotassium (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
57109-90-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C2y C    24.3534  -14.2894
            2   C8y C    23.5113  -13.1798
            3   C8y C    23.8465  -11.8230
            4   N1x N    25.1075  -11.2449
            5   N2x N    25.7592  -14.3146
            6   C5x C    26.3611  -11.8672
            7   C1y C    26.6476  -13.2359
            8   C8x C    22.8394  -10.8546
            9   C8x C    21.4974  -11.2427
            10  C8y C    21.1622  -12.5995
            11  C8x C    22.1693  -13.5676
            12  X   Cl   19.7974  -12.9939
            13  C8y C    23.7189  -15.5391
            14  C8x C    22.3173  -15.5391
            15  C8x C    21.6173  -16.7516
            16  C8x C    22.3173  -17.9640
            17  C8x C    23.7189  -17.9640
            18  C8x C    24.4189  -16.7516
            19  C6a C    27.8601  -13.9359
            20  O6a O    29.0725  -13.2359 #-
            21  O5x O    27.4703  -11.0095
            22  O6a O    27.8601  -15.3300
            23  Z   K    30.5200  -13.3000 #+
            24  Z   K    27.5100  -17.3600
            25  O1a O    28.9100  -17.3600
BOND        25
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   13  18 2
            21    7  19 1
            22   19  20 1
            23    6  21 2
            24   19  22 2
            25   24  25 1

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