KEGG   DRUG: D00695Help
Entry
D00695                      Drug                                   
Name
Flurazepam hydrochloride (USP);
Flurazepam dihydrochloride;
Dalmane (TN)
Product
  Generic
Formula
C21H23ClFN3O. 2HCl
Exact mass
459.1047
Mol weight
460.8001
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsants;
Relaxant [muscle];
Sedative-hypnotic
Remark
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD01 Flurazepam
      D00695  Flurazepam hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Flurazepam [ATC:N05CD01]
      D00695  Flurazepam hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
1172-18-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   X   Cl   36.4700  -16.9400
            2   C2y C    31.1500  -17.4300
            3   C8y C    30.3100  -16.3100
            4   C8y C    30.6600  -14.9100
            5   N1y N    31.9200  -14.3500
            6   N2x N    32.6200  -17.4300
            7   C5x C    33.1800  -14.9800
            8   C1x C    33.4600  -16.3800
            9   C8x C    29.6800  -13.9300
            10  C8x C    28.3500  -14.3500
            11  C8y C    28.0000  -15.6800
            12  C8x C    28.9800  -16.6600
            13  O5x O    34.1600  -14.0700
            14  X   Cl   26.6000  -16.1000
            15  C8y C    30.5200  -18.6900
            16  C8x C    29.1200  -18.6900
            17  C8x C    28.4200  -19.8800
            18  C8x C    29.1200  -21.0700
            19  C8x C    30.5200  -21.0700
            20  C8y C    31.2200  -19.8800
            21  X   F    32.6900  -19.8800
            22  C1b C    31.9200  -12.9500
            23  C1b C    33.1100  -12.3200
            24  N1c N    33.1100  -10.8500
            25  C1b C    34.3000  -10.1500
            26  C1b C    31.9200  -10.1500
            27  C1a C    30.7300  -10.8500
            28  C1a C    35.4900  -10.8500
            29  X   Cl   36.4700  -16.9400
BOND        29
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13    7  13 2
            14   11  14 1
            15    2  15 1
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   15  20 2
            22   20  21 1
            23    5  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   24  26 1
            28   26  27 1
            29   25  28 1
BRACKET     1    35.0000  -17.6400   35.0000  -16.2400
            1    37.2400  -16.2400   37.2400  -17.6400
            1  2
 ORIGINAL  1    1
 REPEAT    1   29

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