KEGG   DRUG: Midazolam hydrochlorideHelp
Entry
D00696                      Drug                                   

Name
Midazolam hydrochloride (USAN);
Versed (TN)
Product
  Generic
MIDAZOLAM (A-S Medication Solutions), MIDAZOLAM (Cardinal Health), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (West-Ward Pharmaceuticals Corp.), MIDAZOLAM (West-Ward Pharmaceuticals Corp.), MIDAZOLAM (West-Ward Pharmaceuticals Corp.), MIDAZOLAM (Akorn), MIDAZOLAM (Alvogen), MIDAZOLAM (Alvogen), MIDAZOLAM (Athenex Pharmaceutical Division), MIDAZOLAM (Athenex Pharmaceutical Division), MIDAZOLAM HYDROCHLORIDE (Atlantic Biologicals Corps), MIDAZOLAM HYDROCHLORIDE (Atlantic Biologicals Corps), MIDAZOLAM HYDROCHLORIDE (Cardinal Health), MIDAZOLAM HYDROCHLORIDE (Cardinal Health), MIDAZOLAM HYDROCHLORIDE (Cardinal Health), MIDAZOLAM HYDROCHLORIDE (Dispensing Solutions), MIDAZOLAM HYDROCHLORIDE (Dispensing Solutions), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM HYDROCHLORIDE (General Injectables & Vaccines), MIDAZOLAM HYDROCHLORIDE (Gland Pharma Limited), MIDAZOLAM HYDROCHLORIDE (Gland Pharma Limited), MIDAZOLAM HYDROCHLORIDE (Heritage Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Heritage Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Paddock Laboratories), MIDAZOLAM HYDROCHLORIDE (Physicians Total Care), MIDAZOLAM HYDROCHLORIDE (Precision Dose), MIDAZOLAM HYDROCHLORIDE (Precision Dose), MIDAZOLAM HYDROCHLORIDE (Ranbaxy Pharmaceuticlas), MIDAZOLAM (Sagent Pharmaceuticals), MIDAZOLAM (Sagent Pharmaceuticals), MIDAZOLAM (Sun Pharmaceutical Industries), MIDAZOLAM (Sun Pharmaceutical Industries), MIDAZOLAM (The Medicines Company), MIDAZOLAM HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), MIDAZOLAM HYDROCHLORIDE (Wockhardt Limited), MIDAZOLAM HYDROCHLORIDE (Wockhardt Limited), MIDAZOLAM HYDROCHLORIDE (Wockhardt USA LLC.), MIDAZOLAM HYDROCHLORIDE (Wockhardt USA LLC.)
  Other
Formula
C18H13ClFN3. HCl
Exact mass
361.0549
Mol weight
362.2283
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
Cyp substrate
 DG01633  CYP3A substrate
Remark
ATC code: N05CD08
Chemical structure group: DG00920
Product (DG00920): D00550<JP> D00696<US>
Efficacy
Anesthetic (intravenous), Sedative-hypnotic
Comment
Benzodiazepines
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD08 Midazolam
      D00696  Midazolam hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Midazolam
      D00696  Midazolam hydrochloride (USAN)
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00696
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00696
BRITE hierarchy
Other DBs
CAS: 59467-96-8
PubChem: 7847761
ChEBI: 6932
ChEMBL: CHEMBL1200420
DrugBank: DB00683
LigandBox: D00696
NIKKAJI: J300.613A
KCF data Show

ATOM        24
            1   X   Cl   37.0651  -16.6762
            2   C2y C    32.2059  -17.5222
            3   C8y C    31.3632  -16.4118
            4   C8y C    31.6986  -15.0540
            5   N4y N    32.9606  -14.4754
            6   N2x N    33.6128  -17.4775
            7   C8y C    34.2151  -15.0982
            8   C1x C    34.5018  -16.4679
            9   C8x C    30.6908  -14.0849
            10  C8x C    29.3478  -14.4732
            11  C8y C    29.0123  -15.8311
            12  C8x C    30.0202  -16.7999
            13  X   Cl   27.6465  -16.2258
            14  C8y C    31.5709  -18.7729
            15  C8x C    30.1683  -18.7729
            16  C8x C    29.4677  -19.9863
            17  C8x C    30.1683  -21.1996
            18  C8x C    31.5709  -21.1996
            19  C8y C    32.2715  -19.9863
            20  X   F    33.6834  -19.9864
            21  C8x C    35.1952  -14.0976
            22  N5x N    34.5463  -12.8563
            23  C8y C    33.1652  -13.0899
            24  C1a C    32.1836  -12.1282
BOND        26
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13   11  13 1
            14    2  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   14  19 2
            21   19  20 1
            22    7  21 2
            23   21  22 1
            24   22  23 2
            25    5  23 1
            26   23  24 1

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