KEGG   DRUG: D00696Help
Entry
D00696                      Drug                                   

Name
Midazolam hydrochloride (USAN);
Versed (TN)
Product
  Generic
MIDAZOLAM (Cardinal Health), MIDAZOLAM (Cardinal Health), MIDAZOLAM (Cardinal Health), MIDAZOLAM (West-ward Pharmaceutical Corp.), MIDAZOLAM HYDROCHLORIDE (A-S Medication Solutions LLC), MIDAZOLAM (APP Pharmaceuticals), MIDAZOLAM (Akorn), MIDAZOLAM HYDROCHLORIDE (Atlantic Biologicals Corps), MIDAZOLAM HYDROCHLORIDE (Baxter Healthcare Corporation), MIDAZOLAM (Caraco Pharmaceutical Laboratories), MIDAZOLAM (Caraco Pharmaceutical Laboratories), MIDAZOLAM HYDROCHLORIDE (Cardinal Health), MIDAZOLAM HYDROCHLORIDE (Cardinal Health), MIDAZOLAM HYDROCHLORIDE (Cardinal Health), MIDAZOLAM HYDROCHLORIDE (Cardinal Health), MIDAZOLAM (Cardinal Health), MIDAZOLAM HYDROCHLORIDE (Cardinal Health), MIDAZOLAM HYDROCHLORIDE (Cardinal Health), MIDAZOLAM HYDROCHLORIDE (Dispensing Solutions), MIDAZOLAM HYDROCHLORIDE (Dispensing Solutions), MIDAZOLAM HYDROCHLORIDE (General Injectables & Vaccines), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Paddock Laboratories), MIDAZOLAM HYDROCHLORIDE (Physicians Total Care), MIDAZOLAM HYDROCHLORIDE (Precision Dose), MIDAZOLAM HYDROCHLORIDE (Ranbaxy Pharmaceuticlas), MIDAZOLAM HYDROCHLORIDE (Roxane Laboratories), MIDAZOLAM (Sagent Pharmaceuticals), MIDAZOLAM (Sagent Pharmaceuticals), MIDAZOLAM (The Medicines Company), MIDAZOLAM HYDROCHLORIDE (Wockhardt Limited), MIDAZOLAM HYDROCHLORIDE (Wockhardt Limited), MIDAZOLAM HYDROCHLORIDE (Wockhardt USA LLC.), MIDAZOLAM HYDROCHLORIDE (Wockhardt USA LLC.)
  Other
Formula
C18H13ClFN3. HCl
Exact mass
361.0549
Mol weight
362.2283
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [injectable]
Remark
ATC code: 
Drug group: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP4B1 [HSA:1580]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD08 Midazolam
      D00696  Midazolam hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Midazolam
      D00696  Midazolam hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Midazolam
    D00696  Midazolam hydrochloride (USAN)
  CYP3A5
   Midazolam
    D00696  Midazolam hydrochloride (USAN)
  CYP3A7
   Midazolam
    D00696  Midazolam hydrochloride (USAN)
  CYP4B1
   Midazolam
    D00696  Midazolam hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
59467-96-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   X   Cl   37.0651  -16.6762
            2   C2y C    32.2059  -17.5222
            3   C8y C    31.3632  -16.4118
            4   C8y C    31.6986  -15.0540
            5   N4y N    32.9606  -14.4754
            6   N2x N    33.6128  -17.4775
            7   C8y C    34.2151  -15.0982
            8   C1x C    34.5018  -16.4679
            9   C8x C    30.6908  -14.0849
            10  C8x C    29.3478  -14.4732
            11  C8y C    29.0123  -15.8311
            12  C8x C    30.0202  -16.7999
            13  X   Cl   27.6465  -16.2258
            14  C8y C    31.5709  -18.7729
            15  C8x C    30.1683  -18.7729
            16  C8x C    29.4677  -19.9863
            17  C8x C    30.1683  -21.1996
            18  C8x C    31.5709  -21.1996
            19  C8y C    32.2715  -19.9863
            20  X   F    33.6834  -19.9864
            21  C8x C    35.1952  -14.0976
            22  N5x N    34.5463  -12.8563
            23  C8y C    33.1652  -13.0899
            24  C1a C    32.1836  -12.1282
BOND        26
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13   11  13 1
            14    2  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   14  19 2
            21   19  20 1
            22    7  21 2
            23   21  22 1
            24   22  23 2
            25    5  23 1
            26   23  24 1

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