KEGG   DRUG: D00702Help
Entry
D00702                      Drug                                   

Name
Buspirone hydrochloride (USP);
Buspar (TN)
Product
  Generic
BUSPIRONE HYDROCHLORIDE (Physicians Total Care), BUSPIRONE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), BUSPIRONE HCL (American Health Packaging), BUSPIRONE HYDROCHLORIDE (AvKARE), BUSPIRONE HYDROCHLORIDE (AvKARE), BUSPIRONE HCL (Bryant Ranch Prepack), BUSPIRONE HCL (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Cadila Healthcare Limited), BUSPIRONE HYDROCHLORIDE (Cardinal Health), BUSPIRONE HCL (Clinical Solutions Wholesale), BUSPIRONE HYDROCHLORIDE (Direct Rx), BUSPIRONE HCL (Dispensing Solutions), BUSPIRONE HCL (Dispensing Solutions), BUSPIRONE HYDROCHLORIDE (Dr. Reddy's Laboratories), BUSPIRONE HYDROCHLORIDE (H.J. Harkins Company), BUSPIRONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BUSPIRONE HCL (Lake Erie Medical DBA Quality Care Products LLC), BUSPIRONE HYDROCHLORIDE (Major Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (McKesson Contract Packaging), BUSPIRONE HYDROCHLORIDE (Mylan Institutional), BUSPIRONE HYDROCHLORIDE (Mylan Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NCS HealthCare of KY), BUSPIRONE HYDROCHLORIDE (NCS HealthCare of KY), BUSPIRONE HYDROCHLORIDE (NCS HealthCare of KY), BUSPIRONE HYDROCHLORIDE (NCS HealthCare of KY), BUSPIRONE HYDROCHLORIDE (New Horizon Rx Group), BUSPIRONE HCL (PD-Rx Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Par Pharmaceutical), BUSPIRONE HYDROCHLORIDE (Preferred Pharmaceuticals), BUSPIRONE HCL (Preferred Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (Rebel Distributors Corp), BUSPIRONE HYDROCHLORIDE (Rebel Distributors Corp), BUSPIRONE HCL (Rebel Distributors Corp.), BUSPIRONE HYDROCHLORIDE (STAT RX USA LLC), BUSPIRONE HCL (STAT RX USA LLC), BUSPIRONE (STAT RX USA LLC), BUSPIRONE HYDROCHLORIDE (STAT Rx USA LLC), BUSPIRONE HCL (State of Florida DOH Central Pharmacy), BUSPIRONE HYDROCHLORIDE (Teva Pharmaceuticals USA), BUSPIRONE HCL (Unit Dose Services), BUSPIRONE HCL (Watson Laboratories), BUSPIRONE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C21H31N5O2. HCl
Exact mass
421.2245
Mol weight
421.9641
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer [minor]
Remark
ATC code: 
Drug group: 
Target
5-HT1A-receptor agonist [HSA:3350] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Structure map
Anxiolytics
Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BE Azaspirodecanedione derivatives
     N05BE01 Buspirone
      D00702  Buspirone hydrochloride (USP)
USP drug classification [BR:br08302]
 Anxiolytics
  Anxiolytics, Other
   Buspirone
    D00702  Buspirone hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1A-receptor
     Buspirone
      D00702  Buspirone hydrochloride (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A
   Buspirone
    D00702  Buspirone hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
33386-08-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C1z C    30.6703  -12.8797
            2   C1x C    29.4326  -12.1783
            3   C1x C    30.6740  -14.2783
            4   C5x C    28.2471  -12.9204
            5   C5x C    29.4419  -15.0222
            6   N1y N    28.2509  -14.3190
            7   O5x O    27.0095  -12.2190
            8   O5x O    29.4440  -16.3742
            9   C1b C    27.0637  -15.0147
            10  C1b C    25.8261  -14.3132
            11  C1b C    24.6389  -15.0088
            12  C1b C    23.4014  -14.3074
            13  N1y N    22.2159  -15.0496
            14  C1x C    20.9783  -14.3482
            15  C1x C    22.2197  -16.4482
            16  C1x C    19.7911  -15.0437
            17  C1x C    20.9859  -17.1454
            18  N1y N    19.7949  -16.4424
            19  C8y C    18.5612  -17.1396
            20  N5x N    17.3702  -16.4366
            21  N5x N    18.5183  -18.5383
            22  C8x C    16.0664  -17.1338
            23  C8x C    17.3311  -19.2338
            24  C8x C    16.0935  -18.5308
            25  C1x C    32.0020  -13.3124
            26  C1x C    32.8245  -12.1795
            27  C1x C    32.0012  -11.0471
            28  C1x C    30.6698  -11.4802
            29  X   Cl   32.5491  -16.1055
BOND        31
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 2
            7     5   8 2
            8     6   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   18  19 1
            19   19  20 1
            20   19  21 2
            21   20  22 2
            22   21  23 1
            23   22  24 1
            24    5   6 1
            25   17  18 1
            26   23  24 2
            27    1  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31    1  28 1

» Japanese version   » Back

DBGET integrated database retrieval system