KEGG   DRUG: D00706Help
Entry
D00706                      Drug                                   

Name
Zolpidem tartrate (JP16/USAN);
Ambien (TN);
Intermezzo (TN)
Product
AMBIEN (A-S Medication Solutions LLC), AMBIEN (A-S Medication Solutions LLC), AMBIEN CR (Bryant Ranch Prepack), AMBIEN CR (Bryant Ranch Prepack), AMBIEN (Bryant Ranch Prepack), ZOLPIMIST (ECR Pharmaceuticals), ZOLPIDEM TARTRATE (KAISER FOUNDATION HOSPITALS), AMBIEN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), AMBIEN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), AMBIEN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), EDLUAR (Meda Pharmaceuticals), AMBIEN (PD-Rx Pharmaceuticals), AMBIEN CR (Physicians Total Care), ZOLPIDEM TARTRATE (Physicians Total Care), INTERMEZZO (Purdue Pharma LP), AMBIEN CR (Rebel Distributors Corp.), AMBIEN (Rebel Distributors Corp.), AMBIEN (STAT Rx USA LLC), AMBIEN (STAT Rx USA LLC), AMBIEN CR (St Marys Medical Park Pharmacy), AMBIEN (sanofi-aventis U.S. LLC), AMBIEN (sanofi-aventis U.S. LLC)
  Generic
ZOLPIDEM TARTRATE (A-S Medication Solutions LLC), ZOLPIDEM TARTRATE (A-S Medication Solutions LLC), ZOLPIDEM TARTRATE (APOTHECA), ZOLPIDEM TARTRATE (Actavis Elizabeth LLC), ZOLPIDEM TARTRATE (Aidarex Pharmaceuticals LLC), ZOLPIDEM TARTRATE (American Health Packaging), ZOLPIDEM TARTRATE (American Health Packaging), ZOLPIDEM TARTRATE (American Health Packaging), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Apotex Corp.), ZOLPIDEM TARTRATE (Aurobindo Pharma Limited), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Cardinal Health), ZOLPIDEM TARTRATE (Cardinal Health), ZOLPIDEM TARTRATE (Cardinal Health), ZOLPIDEM TARTRATE (Cardinal Health), ZOLPIDEM TARTRATE (Cardinal Health), ZOLPIDEM TARTRATE (Cardinal Health), ZOLPIDEM TARTRATE (Carlsbad Technology), ZOLPIDEM TARTRATE (DIRECT RX), ZOLPIDEM TARTRATE (Dispensing Solutions), ZOLPIDEM TARTRATE (Dispensing Solutions), ZOLPIDEM TARTRATE (Dispensing Solutions), ZOLPIDEM TARTRATE (Dr. Reddy's Laboratories Limited), ZOLPIDEM TARTRATE (H.J. Harkins Company), ZOLPIDEM TARTRATE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Life Line Home Care Services), ZOLPIDEM TARTRATE (Lupin Pharmaceuticals), ZOLPIDEM TARTRATE (Major Pharmaceuticals), ZOLPIDEM TARTRATE (McKesson Contract Packaging), ZOLPIDEM TARTRATE (McKesson Packaging Services Business Unit of McKesson Corporation), ZOLPIDEM TARTRATE (Mylan Institutional), ZOLPIDEM TARTRATE (Mylan Pharmaceuticals), ZOLPIDEM TARTRATE (NorthStar Rx LLC), ZOLPIDEM TARTRATE (PD-Rx Pharmaceuticals), ZOLPIDEM TARTRATE (PD-Rx Pharmaceuticals), ZOLPIDEM TARTRATE (PD-Rx Pharmaceuticals), ZOLPIDEM TARTRATE (PD-Rx Pharmaceuticals), ZOLPIDEM TARTRATE (Par Pharmaceutical), ZOLPIDEM TARTRATE (Physicians Total Care), ZOLPIDEM TARTRATE (Physicians Total Care), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Qualitest Pharmaceuticals), ZOLPIDEM TARTRATE (REMEDYREPACK), ZOLPIDEM TARTRATE (REMEDYREPACK), ZOLPIDEM TARTRATE (REMEDYREPACK), ZOLPIDEM TARTRATE (Ranbaxy Pharmaceuticals), ZOLPIDEM TARTRATE (Rebel Distributors Corp.), ZOLPIDEM TARTRATE (RedPharm Drug), ZOLPIDEM TARTRATE (RedPharm Drug), ZOLPIDEM TARTRATE (RedPharm Drug), ZOLPIDEM TARTRATE (RedPharm Drug), ZOLPIDEM TARTRATE (Roxane Laboratories), ZOLPIDEM TARTRATE (STAT Rx USA LLC), ZOLPIDEM TARTRATE (STAT Rx USA LLC), ZOLPIDEM TARTRATE (Sandoz), ZOLPIDEM TARTRATE (Sandoz), ZOLPIDEM TARTRATE (St Marys Medical Park Pharmacy), ZOLPIDEM TARTRATE EXTENDED RELEASE (St Marys Medical Park Pharmacy), ZOLPIDEM TARTRATE (TYA Pharmaceuticals), ZOLPIDEM TARTRATE (Teva Pharmaceuticals USA), ZOLPIDEM TARTRATE (Torrent Pharmaceuticals Limited), ZOLPIDEM TARTRATE (Unit Dose Services), ZOLPIDEM TARTRATE (Unit Dose Services), ZOLPIDEM TARTRATE (Watson Laboratories), ZOLPIDEM (West-ward Pharmaceutical Corp), ZOLPIDEM TARTRATE (Winthrop U.S), ZOLPIDEM TARTRATE (Wockhardt Limited), ZOLPIDEM TARTRATE (Wockhardt USA LLC.)
Formula
(C19H21N3O)2. C4H6O6
Exact mass
764.3534
Mol weight
764.8659
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Sedative-hypnotic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
imidazopyridines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C9 [HSA:1559], Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CF Benzodiazepine related drugs
     N05CF02 Zolpidem
      D00706  Zolpidem tartrate (JP16/USAN)
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  GABA Receptor Modulators
   Zolpidem
    D00706  Zolpidem tartrate (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1129  Others
     D00706  Zolpidem tartrate (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Zolpidem
      D00706  Zolpidem tartrate (JP16/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Zolpidem
    D00706  Zolpidem tartrate (JP16/USAN)
  CYP2C9
   Zolpidem
    D00706  Zolpidem tartrate (JP16/USAN)
  CYP3A4
   Zolpidem
    D00706  Zolpidem tartrate (JP16/USAN)
   Zolpidem
    D00706  Zolpidem tartrate (JP16/USAN)
  CYP3A5
   Zolpidem
    D00706  Zolpidem tartrate (JP16/USAN)
  CYP3A7
   Zolpidem
    D00706  Zolpidem tartrate (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00706  Zolpidem tartrate
  D00706  Zolpidem tartrate tablets
BRITE hierarchy
Other DBs
CAS: 
99294-93-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        56
            1   C8y C    19.9502  -16.5666
            2   C8y C    20.7843  -15.4409
            3   N4y N    18.6204  -16.1292
            4   C1b C    19.9445  -17.9607
            5   C8y C    22.1841  -15.4469
            6   N5x N    19.9562  -14.2979
            7   C8y C    18.6263  -14.7236
            8   C8x C    17.4130  -16.8291
            9   C5a C    21.1576  -18.6547
            10  C8x C    22.8783  -16.6542
            11  C8x C    22.8900  -14.2336
            12  C8x C    17.4130  -14.0237
            13  C8y C    16.1942  -16.1234
            14  N1c N    21.1576  -20.0546
            15  O5a O    22.3709  -17.9490
            16  C8x C    24.2782  -16.6600
            17  C8x C    24.2898  -14.2395
            18  C8x C    16.1942  -14.7236
            19  C1a C    14.9809  -16.8291
            20  C1a C    22.3709  -20.7428
            21  C1a C    19.9445  -20.7487
            22  C8y C    24.9838  -15.4585
            23  C1a C    26.3837  -15.4643
            24  C1c C    32.6423  -17.7973
            25  C1c C    33.8437  -17.0974
            26  C6a C    31.4292  -17.1033
            27  O1a O    32.6423  -19.1972
            28  C6a C    35.0570  -17.7856
            29  O1a O    33.8437  -15.6918
            30  O6a O    30.2159  -17.8032
            31  O6a O    31.4233  -15.7035
            32  O6a O    36.2701  -17.0916
            33  O6a O    35.0511  -19.1914
            34  C8y C    19.9502  -16.5666
            35  C8y C    20.7843  -15.4409
            36  C8y C    22.1841  -15.4469
            37  C8x C    22.8783  -16.6542
            38  C8x C    24.2782  -16.6600
            39  C8y C    24.9838  -15.4585
            40  C1a C    26.3837  -15.4643
            41  C8x C    24.2898  -14.2395
            42  C8x C    22.8900  -14.2336
            43  N5x N    19.9562  -14.2979
            44  C8y C    18.6263  -14.7236
            45  N4y N    18.6204  -16.1292
            46  C8x C    17.4130  -16.8291
            47  C8y C    16.1942  -16.1234
            48  C1a C    14.9809  -16.8291
            49  C8x C    16.1942  -14.7236
            50  C8x C    17.4130  -14.0237
            51  C1b C    19.9445  -17.9607
            52  C5a C    21.1576  -18.6547
            53  N1c N    21.1576  -20.0546
            54  C1a C    22.3709  -20.7428
            55  C1a C    19.9445  -20.7487
            56  O5a O    22.3709  -17.9490
BOND        59
            1    24  25 1
            2    24  26 1
            3    24  27 1 #Up
            4    25  28 1
            5    25  29 1 #Up
            6    26  30 1
            7    26  31 2
            8    28  32 1
            9    28  33 2
            10    1   2 2
            11    1   3 1
            12    1   4 1
            13    2   5 1
            14    2   6 1
            15    3   7 1
            16    3   8 1
            17    4   9 1
            18    5  10 2
            19    5  11 1
            20    7  12 1
            21    8  13 2
            22    9  14 1
            23    9  15 2
            24   10  16 1
            25   11  17 2
            26   12  18 2
            27   13  19 1
            28   14  20 1
            29   14  21 1
            30   16  22 2
            31   22  23 1
            32    6   7 2
            33   13  18 1
            34   17  22 1
            35   34  35 2
            36   34  45 1
            37   34  51 1
            38   35  36 1
            39   35  43 1
            40   45  44 1
            41   45  46 1
            42   51  52 1
            43   36  37 2
            44   36  42 1
            45   44  50 1
            46   46  47 2
            47   52  53 1
            48   52  56 2
            49   37  38 1
            50   42  41 2
            51   50  49 2
            52   47  48 1
            53   53  54 1
            54   53  55 1
            55   38  39 2
            56   39  40 1
            57   43  44 2
            58   47  49 1
            59   41  39 1
BRACKET     1    13.0900  -21.8400   13.0900  -12.8100
            1    28.1400  -12.8100   28.1400  -21.8400
            1  2
 ORIGINAL  1    1   2   5  10  16  22  23  17  11   6   7   3   8  13  19  18
            1   12   4   9  14  20  21  15
 REPEAT    1   34  35  36  37  38  39  40  41  42  43  44  45  46  47  48  49
            1   50  51  52  53  54  55  56

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