KEGG   DRUG: D00710Help
Entry
D00710                      Drug                                   
Name
Sodium valproate (JP16);
Valproate sodium (USAN);
Depakene (TN);
Selenica (TN)
Product
  Generic
Formula
C8H15O2. Na
Exact mass
166.097
Mol weight
166.1933
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant
Remark
Therapeutic category: 
ATC code: 
Comment
Valproic acid is contraindicated in patients with known urea cycle disorders [DS:H00164 H00185 H00186 H00187 H01028 H01032]
Target
GABA transaminase inhibitor [HSA:18] [KO:K13524];
calcium channel T type blocker [HSA:8911 8912 8913] [KO:K04856 K04855 K04854];
histone acetyltransferase inhibitor [HSA:203611 253175 9085 9426] [KO:K00653];
histone deacetylases (HDACs) inhibitor [HSA:3065 3066 8841 9759 10014 10013 51564 55869 9734 83933] [KO:K06067 K11404 K11406 K11407 K11408 K11405 K11409]
  Pathway
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00280  Valine, leucine and isoleucine degradation
hsa00410  beta-Alanine metabolism
hsa00640  Propanoate metabolism
hsa00650  Butanoate metabolism
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: NAGS [HSA:162417], CPS [HSA:1373], ASS [HSA:445], OTC [HSA:5009], ASL [HSA:435], ARG [HSA:383 384]
Drug interaction
Structure map
Anticonvulsants
Calcium channel blocking drugs
Antimigraines
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00710  Sodium valproate (JP16); Valproate sodium (USAN)
   117  Psychotropics
    1179  Others
     D00710  Sodium valproate (JP16); Valproate sodium (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AG Fatty acid derivatives
     N03AG01 Valproic acid
      D00710  Sodium valproate (JP16); Valproate sodium (USAN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Valproate
    D00710  Sodium valproate (JP16); Valproate sodium (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel T type [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
     Valproic acid [ATC:N03AG01]
      D00710  Valproate sodium (USAN)
 Enzymes
  Transferases
   histone acetyltransferase [HSA:203611 253175 9085 9426] [KO:K00653]
    Valproic acid [ATC:N03AG01]
     D00710  Valproate sodium (USAN)
   GABA transaminase [HSA:18] [KO:K13524]
    Valproic acid [ATC:N03AG01]
     D00710  Valproate sodium (USAN)
  Hydrolases
   histone deacetylase [HSA:3065 3066 8841 9759 10014 10013 51564 55869 9734 83933] [KO:K06067 K11404 K11405 K11406 K11407 K11408 K11409]
    Valproic acid [ATC:N03AG01]
     D00710  Sodium valproate (JP16); Valproate sodium (USAN)
BRITE hierarchy
Other DBs
CAS: 
1069-66-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        11
            1   C1c C    24.8619  -18.6957
            2   C1b C    24.8619  -17.3175
            3   C1b C    23.6530  -19.4139
            4   C6a C    26.0650  -19.4139
            5   C1b C    23.6472  -16.6109
            6   C1b C    22.4441  -18.6957
            7   O6a O    27.2738  -18.6957
            8   O6a O    26.0650  -20.8098 #-
            9   C1a C    22.4384  -17.3175
            10  C1a C    21.2412  -19.4139
            11  Z   Na   28.5001  -20.7280 #+
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 1

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