KEGG   DRUG: D00715Help
Entry
D00715                      Drug                                   

Name
Hyoscine methobromide (INN);
Methscopolamine bromide;
Pamine (TN)
Product
  Generic
Formula
C18H24NO4. Br
Exact mass
397.0889
Mol weight
398.2915
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticholinergic
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Methscopolamine
    D00715  Hyoscine methobromide (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Hyoscine
      D00715  Hyoscine methobromide (INN)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D00715  Hyoscine methobromide (INN)
BRITE hierarchy
Other DBs
CAS: 
155-41-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   X   Br   39.7175  -18.0800 #-
            2   C1y C    27.7900  -17.2900
            3   C1y C    27.1600  -18.3400
            4   C1y C    28.7000  -16.9400
            5   O2x O    26.2500  -17.2900
            6   C1y C    28.4900  -17.8500
            7   N2y N    27.7200  -15.8900 #+
            8   C1x C    30.1700  -16.9400
            9   C1x C    30.1000  -17.8500
            10  C1a C    28.0700  -14.6300
            11  C1a C    26.4600  -15.1900
            12  C1y C    31.4300  -18.4100
            13  O7a O    32.4100  -19.1800
            14  C7a C    33.8100  -19.1800
            15  O6a O    34.4400  -20.3700
            16  C1c C    34.4400  -18.0600
            17  C8y C    35.7700  -18.0600
            18  C1b C    33.8100  -16.8700
            19  O1a O    34.4400  -15.6800
            20  C8x C    36.4700  -19.2500
            21  C8x C    37.8000  -19.2500
            22  C8x C    38.5000  -18.0600
            23  C8x C    37.8000  -16.8700
            24  C8x C    36.4700  -16.8700
BOND        26
            1     2   3 1
            2     2   4 1
            3     2   5 1
            4     3   6 1
            5     4   7 1
            6     4   8 1
            7     6   9 1
            8     7  10 1
            9     7  11 1
            10    8  12 1
            11   12  13 1 #Down
            12    3   5 1
            13    6   7 1
            14    9  12 1
            15   13  14 1
            16   14  15 2
            17   14  16 1
            18   16  17 1 #Down
            19   16  18 1
            20   18  19 1
            21   17  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   17  24 1

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