KEGG   DRUG: D00719Help
Entry
D00719                      Drug                                   

Name
Hyoscyamine sulfate (USP);
Hyoscyamine sulfate dihydrate;
Egacene (TN)
Product
  Other
HYOSCYAMINE SULFATE (Aidarex Pharmaceuticals LLC), LEVSIN (Alaven Pharmaceutical LLC), NULEV (Alaven Pharmaceutical LLC), LEVSIN (Alaven Pharmaceutical LLC), LEVSIN (Alaven Pharmaceutical LLC), ANASPAZ (BF ASCHER AND), HYOSCYAMINE SULFATE (Bryant Ranch Prepack), SYMAX DUOTAB (Capellon Pharmaceuticals), SYMAX FASTAB (Capellon Pharmaceuticals), SYMAX SL (Capellon Pharmaceuticals), SYMAX SR (Capellon Pharmaceuticals), HYOSCYAMINE SULFATE (Carilion Materials Management), HYOSCYAMINE SULFATE (Clinical Solutions Wholesale), HYOSCYAMINE SULFATE (County Line Pharmaceuticals), HYOSCYAMINE SULFATE (County Line Pharmaceuticals), HYOSCYAMINE SULFATE (County Line Pharmaceuticals), HYOSCYAMINE SULFATE (Cypress Pharmaceutical), HYOSCYAMINE SULFATE (Cypress Pharmaceutical), ED-SPAZ (EDWARDS PHARMACEUTICALS), HYOSCYAMINE SULFATE (Franklin Pharmaceutical LLC), HYOSCYAMINE SULFATE SL (Franklin Pharmaceutical LLC), HYOSCYAMINE SULFATE (Franklin Pharmaceutical LLC), HYOSCYAMINE SULFATE (KAISER FOUNDATION HOSPITALS), OSCIMIN (Larken Laboratories), OSCIMIN (Larken Laboratories), OSCIMIN (Larken Laboratories), OSCIMIN (Larken Laboratories), HYOSCYAMINE SULFATE (Method Pharmaceuticals), HYOSCYAMINE SULFATE (PD-Rx Pharmaceuticals), HYOSCYAMINE SULFATE (Paddock Laboratories), HYOSCYAMINE SULFATE (Paddock Laboratories), HYOSCYAMINE SULFATE (Paddock Laboratories), HYOSCYAMINE (Patrin Pharma), HYOSCYAMINE (Patrin Pharma), HYOSCYAMINE SULFATE (Proficient Rx LP), HYOSCYAMINE SULFATE (Rebel Distributors Corp), HYOSCYAMINE SULFATE (Rebel Distributors Corp), HYOSYNE (Silarx Pharmaceuticals), HYOSYNE (Silarx Pharmaceuticals), HYOSCYAMINE SULFATE (Virtus Pharmaceuticals), HYOSCYAMINE SULFATE (Virtus Pharmaceuticals), HYOSCYAMINE SULFATE SL (Virtus Pharmaceuticals), HYOSCYAMINE SULFATE EXTENDED-RELEASE (Aidarex Pharmaceuticals LLC), HYOSCYAMINE SULFATE EXTENDED-RELEASE (Carilion Materials Management), HYOSCYAMINE SULFATE EXTENDED-RELEASE (County Line Pharmaceuticals)
Formula
(C17H23NO3. H2O)2. H2SO4
Exact mass
712.3241
Mol weight
712.8479
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticholinergic
Remark
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03B BELLADONNA AND DERIVATIVES, PLAIN
    A03BA Belladonna alkaloids, tertiary amines
     A03BA03 Hyoscyamine
      D00719  Hyoscyamine sulfate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Hyoscyamine
      D00719  Hyoscyamine sulfate (USP)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D00719  Hyoscyamine sulfate (USP)
BRITE hierarchy
Other DBs
CAS: 
6835-16-1
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        49
            1   S4a S    37.4113  -13.8292
            2   O1d O    36.0485  -13.8935
            3   O1d O    38.7795  -13.8292
            4   O1d O    37.4054  -12.4667
            5   O1d O    37.4054  -15.1920
            6   O0  O    31.6463  -11.2177
            7   C1x C    23.0857  -14.9648
            8   C1x C    23.4059  -13.8213
            9   C1y C    24.2293  -14.6904
            10  C1y C    24.5495  -13.5469
            11  N1y N    23.3145  -12.2660
            12  C1x C    26.0589  -14.6904
            13  C1x C    25.7845  -13.5469
            14  C1y C    27.0653  -15.2393
            15  O7a O    28.1174  -16.1084
            16  C7a C    29.3067  -16.1084
            17  C1c C    29.9014  -15.0563
            18  O6a O    29.9014  -17.2062
            19  C8y C    31.0907  -15.0563
            20  C1b C    29.3067  -14.0500
            21  O1a O    29.9014  -12.9980
            22  C8x C    31.7800  -16.2506
            23  C8x C    33.1463  -16.2509
            24  C8x C    33.8297  -15.0677
            25  C8x C    33.1405  -13.8735
            26  C8x C    31.7742  -13.8732
            27  C1a C    22.5834  -11.1103
            28  O0  O    31.6463  -11.2177
            29  C1x C    23.0857  -14.9648
            30  C1x C    23.4059  -13.8213
            31  C1y C    24.5495  -13.5469
            32  C1x C    25.7845  -13.5469
            33  C1y C    27.0653  -15.2393
            34  C1x C    26.0589  -14.6904
            35  C1y C    24.2293  -14.6904
            36  N1y N    23.3145  -12.2660
            37  C1a C    22.5834  -11.1103
            38  O7a O    28.1174  -16.1084
            39  C7a C    29.3067  -16.1084
            40  C1c C    29.9014  -15.0563
            41  C8y C    31.0907  -15.0563
            42  C8x C    31.7800  -16.2506
            43  C8x C    33.1463  -16.2509
            44  C8x C    33.8297  -15.0677
            45  C8x C    33.1405  -13.8735
            46  C8x C    31.7742  -13.8732
            47  C1b C    29.3067  -14.0500
            48  O1a O    29.9014  -12.9980
            49  O6a O    29.9014  -17.2062
BOND        50
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     1   5 2
            5     7   8 1
            6     7   9 1
            7     8  10 1
            8     9  11 1
            9     9  12 1
            10   10  13 1
            11   12  14 1
            12   14  15 1 #Down
            13   15  16 1
            14   16  17 1
            15   16  18 2
            16   17  19 1
            17   17  20 1 #Down
            18   20  21 1
            19   10  11 1
            20   13  14 1
            21   19  22 2
            22   22  23 1
            23   23  24 2
            24   24  25 1
            25   25  26 2
            26   19  26 1
            27   11  27 1
            28   29  30 1
            29   29  35 1
            30   30  31 1
            31   35  36 1
            32   35  34 1
            33   31  32 1
            34   34  33 1
            35   33  38 1 #Down
            36   38  39 1
            37   39  40 1
            38   39  49 2
            39   40  41 1
            40   40  47 1 #Down
            41   47  48 1
            42   31  36 1
            43   32  33 1
            44   41  42 2
            45   42  43 1
            46   43  44 2
            47   44  45 1
            48   45  46 2
            49   41  46 1
            50   36  37 1
BRACKET     1    20.8600  -18.0600   20.8600   -9.8000
            1    34.2300   -9.8000   34.2300  -18.0600
            1  2
 ORIGINAL  1    6   7   8  10  13  14  12   9  11  29  22  15  16  17  19  24
            1   25  26  27  28  20  21  18  23
 REPEAT    1   30  31  32  33  34  35  36  37  38  39  40  41  42  43  44  45
            1   46  47  48  49  50  51  52  53

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