KEGG   DRUG: D00726Help
Entry
D00726                      Drug                                   

Name
Metoclopramide (JP16/INN);
Elieten (TN);
Terperan (TN)
Formula
C14H22ClN3O2
Exact mass
299.1401
Mol weight
299.7964
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiemetic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
5-HT4-receptor agonist [HSA:3360] [KO:K04160];
5-HT3-receptor antagonist [HSA:3359 9177 170572 200909 285242] [KO:K04819]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYB5R [HSA:51706 51700 1727 51167]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antipsychotics
Antimigraines
Serotonin receptor agonists/antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03F PROPULSIVES
    A03FA Propulsives
     A03FA01 Metoclopramide
      D00726  Metoclopramide (JP16/INN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Metoclopramide
    D00726  Metoclopramide (JP16/INN)
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Metoclopramide
    D00726  Metoclopramide (JP16/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00726  Metoclopramide (JP16/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Metoclopramide
      D00726  Metoclopramide (JP16/INN)
   Serotonin
    5-HT3-receptor
     Metoclopramide
      D00726  Metoclopramide (JP16/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Metoclopramide
    D00726  Metoclopramide (JP16/INN)
 Inhbitors
  CYP2D6
   Metoclopramide
    D00726  Metoclopramide (JP16/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00726  Metoclopramide
  D00726  Metoclopramide tablets
BRITE hierarchy
Other DBs
CAS: 
364-62-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C8y C    27.1658  -16.8047
            2   C8y C    27.1658  -15.4044
            3   C8x C    25.9755  -17.5049
            4   C5a C    28.4261  -17.5049
            5   C8x C    25.9755  -14.7043
            6   O2a O    28.4261  -14.7043
            7   C8y C    24.7854  -16.8047
            8   N1b N    29.6164  -16.8047
            9   O5a O    28.4261  -18.9052
            10  C8y C    24.7854  -15.4044
            11  C1a C    29.6164  -15.4044
            12  X   Cl   23.5951  -17.5049
            13  C1b C    30.8766  -17.5049
            14  N1a N    23.5951  -14.7043
            15  C1b C    32.0669  -16.8047
            16  N1c N    33.2572  -17.5049
            17  C1b C    34.5175  -16.8047
            18  C1b C    33.2572  -18.9052
            19  C1a C    35.7077  -17.5049
            20  C1a C    34.5175  -19.6053
BOND        20
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13   10  14 1
            14   13  15 1
            15   15  16 1
            16   16  17 1
            17   16  18 1
            18   17  19 1
            19   18  20 1
            20    7  10 2

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