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Entry
D00732                      Drug                                   

Name
Chloroprocaine hydrochloride (USP);
Nesacaine (TN)
Product
  Generic
Formula
C13H19ClN2O2. HCl
Exact mass
306.0902
Mol weight
307.2161
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [local]
Remark
ATC code: 
Drug group: 
Target
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA04 Chloroprocaine
      D00732  Chloroprocaine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Chloroprocaine
      D00732  Chloroprocaine hydrochloride (USP)
    voltage-gated sodium channel (SCN2A)
     Chloroprocaine
      D00732  Chloroprocaine hydrochloride (USP)
    voltage-gated sodium channel (SCN3A)
     Chloroprocaine
      D00732  Chloroprocaine hydrochloride (USP)
    voltage-gated sodium channel (SCN4A)
     Chloroprocaine
      D00732  Chloroprocaine hydrochloride (USP)
    voltage-gated sodium channel (SCN5A)
     Chloroprocaine
      D00732  Chloroprocaine hydrochloride (USP)
    voltage-gated sodium channel (SCN8A)
     Chloroprocaine
      D00732  Chloroprocaine hydrochloride (USP)
    voltage-gated sodium channel (SCN9A)
     Chloroprocaine
      D00732  Chloroprocaine hydrochloride (USP)
    voltage-gated sodium channel (SCN10A)
     Chloroprocaine
      D00732  Chloroprocaine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
3858-89-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8y C    18.6136  -14.8634
            2   C8y C    18.6136  -13.4572
            3   C7a C    19.8213  -15.5576
            4   C8x C    17.3999  -15.5576
            5   C8x C    17.3999  -12.7511
            6   X   Cl   19.8213  -12.7511
            7   O7a O    21.0350  -14.8691
            8   O6a O    19.8155  -16.9639
            9   C8x C    16.1863  -14.8634
            10  C8y C    16.1863  -13.4572
            11  C1b C    22.2428  -15.5693
            12  N1a N    14.9669  -12.7628
            13  C1b C    23.4564  -14.8750
            14  N1c N    24.6701  -15.5752
            15  C1b C    25.8780  -14.8808
            16  C1b C    24.6701  -16.9697
            17  C1a C    27.0915  -15.5810
            18  C1a C    25.8780  -17.6815
            19  X   Cl   25.2536  -12.9728
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    7  11 1
            11   10  12 1
            12   11  13 1
            13   13  14 1
            14   14  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18    9  10 2

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