KEGG   DRUG: D00733Help
Entry
D00733                      Drug                                   

Name
Dibucaine (USP);
Cinchocaine (INN);
Nupercaine (TN)
Formula
C20H29N3O2
Exact mass
343.226
Mol weight
343.4632
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [local]
Remark
Target
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Drug interaction
Structure map
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD04 Cinchocaine
      D00733  Dibucaine (USP); Cinchocaine (INN)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB02 Cinchocaine
      D00733  Dibucaine (USP); Cinchocaine (INN)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB06 Cinchocaine
      D00733  Dibucaine (USP); Cinchocaine (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA06 Cinchocaine
      D00733  Dibucaine (USP); Cinchocaine (INN)
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA04 Cinchocaine
      D00733  Dibucaine (USP); Cinchocaine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
     Cinchocaine [ATC:C05AD04 D04AB02 N01BB06 S01HA06]
      D00733  Dibucaine (USP); Cinchocaine (INN)
    voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
     Cinchocaine [ATC:C05AD04 D04AB02 N01BB06 S01HA06]
      D00733  Dibucaine (USP); Cinchocaine (INN)
    voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
     Cinchocaine [ATC:C05AD04 D04AB02 N01BB06 S01HA06]
      D00733  Dibucaine (USP); Cinchocaine (INN)
    voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
     Cinchocaine [ATC:C05AD04 D04AB02 N01BB06 S01HA06]
      D00733  Dibucaine (USP); Cinchocaine (INN)
    voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
     Cinchocaine [ATC:C05AD04 D04AB02 N01BB06 S01HA06]
      D00733  Dibucaine (USP); Cinchocaine (INN)
    voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
     Cinchocaine [ATC:C05AD04 D04AB02 N01BB06 S01HA06]
      D00733  Dibucaine (USP); Cinchocaine (INN)
    voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
     Cinchocaine [ATC:C05AD04 D04AB02 N01BB06 S01HA06]
      D00733  Dibucaine (USP); Cinchocaine (INN)
    voltage-gated sodium channel (SCN10A) [HSA:6336] [KO:K04842]
     Cinchocaine [ATC:C05AD04 D04AB02 N01BB06 S01HA06]
      D00733  Dibucaine (USP); Cinchocaine (INN)
BRITE hierarchy
Other DBs
CAS: 
85-79-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8x C     5.5300  -17.6400
            2   C8x C     5.5300  -19.0400
            3   C8x C     6.7424  -19.7400
            4   C8y C     7.9549  -19.0400
            5   C8y C     7.9549  -17.6400
            6   C8x C     6.7424  -16.9400
            7   N5x N     9.1673  -19.7400
            8   C8y C    10.3797  -19.0400
            9   C8x C    10.3797  -17.6400
            10  C8y C     9.1673  -16.9400
            11  O2a O    11.5773  -19.7315
            12  C5a C     9.1673  -15.5400
            13  N1b N    10.3818  -14.8388
            14  C1b C    11.5783  -15.5298
            15  C1b C    12.7651  -14.8446
            16  N1c N    13.9566  -15.5328
            17  O5a O     7.9569  -14.8412
            18  C1b C    15.1460  -14.8461
            19  C1b C    13.9566  -16.9397
            20  C1a C    15.1490  -17.6284
            21  C1a C    16.3362  -15.5335
            22  C1b C    12.7656  -19.0455
            23  C1b C    13.9564  -19.7331
            24  C1b C    15.1460  -19.0463
            25  C1a C    16.3361  -19.7335
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    8  11 1
            13   10  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   12  17 2
            19   16  18 1
            20   16  19 1
            21   19  20 1
            22   18  21 1
            23   11  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1

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