KEGG   DRUG: D00738Help
Entry
D00738                      Drug                                   

Name
Mepivacaine hydrochloride (JP16/USP);
Carbocaine (TN);
Polocaine (TN);
Scandonest plain (TN)
Product
  Generic
Formula
C15H22N2O. HCl
Exact mass
282.1499
Mol weight
282.8089
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [local]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Drug interaction
Structure map
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB03 Mepivacaine
      D00738  Mepivacaine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D00738  Mepivacaine hydrochloride (JP16/USP)
 2  Agents affecting individual organs
  27  Dental preparations
   271  Local anesthetics
    2710  Local anesthetics
     D00738  Mepivacaine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Mepivacaine
      D00738  Mepivacaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN2A)
     Mepivacaine
      D00738  Mepivacaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN3A)
     Mepivacaine
      D00738  Mepivacaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN4A)
     Mepivacaine
      D00738  Mepivacaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN5A)
     Mepivacaine
      D00738  Mepivacaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN8A)
     Mepivacaine
      D00738  Mepivacaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN9A)
     Mepivacaine
      D00738  Mepivacaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN10A)
     Mepivacaine
      D00738  Mepivacaine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00738  Mepivacaine hydrochloride
  D00738  Mepivacaine hydrochloride injection
BRITE hierarchy
Other DBs
CAS: 
1722-62-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8y C    25.1484  -18.8245
            2   N1b N    26.3434  -19.5181
            3   C8y C    23.9361  -19.5181
            4   C8y C    25.1484  -17.4196
            5   C5a C    27.5559  -18.8245
            6   C8x C    22.7179  -18.8245
            7   C1a C    23.9244  -20.9228
            8   C8x C    23.9361  -16.7202
            9   C1a C    26.1277  -16.4230
            10  C1y C    28.7682  -19.5181
            11  O5a O    27.5500  -17.4196
            12  C8x C    22.7179  -17.4196
            13  N1y N    28.7625  -20.9228
            14  C1x C    29.9807  -18.8303
            15  C1x C    29.9631  -21.6339
            16  C1a C    27.5442  -21.6223
            17  C1x C    31.1930  -19.5355
            18  C1x C    31.2514  -20.9344
            19  X   Cl   33.1100  -18.7600
BOND        19
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 2
            6     3   7 1
            7     4   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 1
            12   10  13 1
            13   10  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   15  18 1
            18    8  12 2
            19   17  18 1

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