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Entry
D00740                      Drug                                   

Name
Procaine hydrochloride (JP16/USP);
Novocain (TN)
Formula
C13H20N2O2. HCl
Exact mass
272.1292
Mol weight
272.771
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [local]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
voltage-gated potassium channel (KCNK5) blocker [HSA:8645] [KO:K04916];
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
ryanodine receptor antagonist [HSA:6261 6262 6263] [KO:K04961 K04962 K04963]
  Pathway
hsa04020  Calcium signaling pathway  
 
Interaction
Drug interaction
Structure map
Local analgesics
Antiarrhythmic drugs
Benzoic acid family
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD05 Procaine
      D00740  Procaine hydrochloride (JP16/USP)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA02 Procaine
      D00740  Procaine hydrochloride (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA05 Procaine
      D00740  Procaine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1211  Aminobenzoate alkamine esters
     D00740  Procaine hydrochloride (JP16/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  -- Solution for hemorrhoid
   D00740  Procaine hydrochloride (JP16/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Procaine
    D00740  Procaine hydrochloride (JP16/USP)
Pharmaceutical additives [BR:br08316]
 Soothing agent
  D00740  [001159] Procaine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ryanodine and IP3 receptors
   Ryanodine receptor (RYR)
    ryanodine receptor (RYR1)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
    ryanodine receptor (RYR2)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
    ryanodine receptor (RYR3)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN2A)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN3A)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN4A)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN5A)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN8A)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN9A)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN10A)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
   K+ channel, KCNK, K2px.x
    voltage-gated potassium channel (KCNK5)
     Procaine
      D00740  Procaine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00740  Procaine hydrochloride
  D00740  Procaine hydrochloride injection
BRITE hierarchy
Other DBs
CAS: 
51-05-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    19.4210  -17.9429
            2   C7a C    20.6303  -18.6322
            3   C8x C    19.4210  -16.5350
            4   C8x C    18.2117  -18.6380
            5   O7a O    21.8454  -17.9369
            6   O6a O    20.6244  -20.0401
            7   C8x C    18.2117  -15.8340
            8   C8x C    16.9967  -17.9429
            9   C1b C    23.0606  -18.6263
            10  C8y C    16.9967  -16.5350
            11  C1b C    24.2757  -17.9254
            12  N1a N    15.7757  -15.8397
            13  N1c N    25.4909  -18.6205
            14  C1b C    26.6942  -17.9195
            15  C1b C    25.4909  -20.0167
            16  C1a C    27.9093  -18.6146
            17  C1a C    26.6942  -20.7237
            18  X   Cl   30.4040  -20.5309
BOND        17
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  10 2

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