KEGG   DRUG: Procaine hydrochlorideHelp
Entry
D00740                      Drug                                   

Name
Procaine hydrochloride (JP17/USP);
Novocain (TN)
Formula
C13H20N2O2. HCl
Exact mass
272.1292
Mol weight
272.771
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01675  Local anesthetic
  DG01674  Esterified local anesthetic
Unclassified
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01674  Esterified local anesthetic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Anesthetic (local)
Comment
Ester-type
Target
KCNK5 [HSA:8645] [KO:K04916];
SCN10A [HSA:6336] [KO:K04842];
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841];
RYR [HSA:6261 6262 6263] [KO:K04961 K04962 K04963]
  Pathway
Calcium signaling pathway
Interaction
Drug interaction
Structure map
Local analgesics
Antiarrhythmic drugs
Benzoic acid family
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD05 Procaine
      D00740  Procaine hydrochloride (JP17/USP)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA02 Procaine
      D00740  Procaine hydrochloride (JP17/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA05 Procaine
      D00740  Procaine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1211  Aminobenzoate alkamine esters
     D00740  Procaine hydrochloride (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00740  Procaine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Procaine
    D00740  Procaine hydrochloride (JP17/USP)
Pharmaceutical additives [BR:br08316]
 Soothing agent
  D00740  [001159] Procaine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ryanodine and IP3 receptors
   Ryanodine receptor (RYR)
    ryanodine receptor (RYR1)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
    ryanodine receptor (RYR2)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
    ryanodine receptor (RYR3)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN2A)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN3A)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN4A)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN5A)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN8A)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN9A)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN10A)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
   K+ channel, KCNK, K2px.x
    voltage-gated potassium channel (KCNK5)
     Procaine
      D00740  Procaine hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00740  Procaine hydrochloride
  D00740  Procaine hydrochloride injection
Anesthetics, analgesics and anti-inflammatory drugs [br08369.html]
 Anesthetics
  D00740
BRITE hierarchy
Other DBs
CAS: 
51-05-8
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    19.4210  -17.9429
            2   C7a C    20.6303  -18.6322
            3   C8x C    19.4210  -16.5350
            4   C8x C    18.2117  -18.6380
            5   O7a O    21.8454  -17.9369
            6   O6a O    20.6244  -20.0401
            7   C8x C    18.2117  -15.8340
            8   C8x C    16.9967  -17.9429
            9   C1b C    23.0606  -18.6263
            10  C8y C    16.9967  -16.5350
            11  C1b C    24.2757  -17.9254
            12  N1a N    15.7757  -15.8397
            13  N1c N    25.4909  -18.6205
            14  C1b C    26.6942  -17.9195
            15  C1b C    25.4909  -20.0167
            16  C1a C    27.9093  -18.6146
            17  C1a C    26.6942  -20.7237
            18  X   Cl   30.4040  -20.5309
BOND        17
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  10 2

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