KEGG   DRUG: D00741Help
Entry
D00741                      Drug                                   

Name
Tetracaine hydrochloride (JP16/USP);
Protocaine hydrochloride (TN)
Product
  Other
Formula
C15H24N2O2. HCl
Exact mass
300.1605
Mol weight
300.8242
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [local]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842]
Interaction
Drug interaction
Structure map
Local analgesics
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD02 Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB06 Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA03 Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA03 Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1211  Aminobenzoate alkamine esters
     D00741  Tetracaine hydrochloride (JP16/USP)
 2  Agents affecting individual organs
  27  Dental preparations
   271  Local anesthetics
    2710  Local anesthetics
     D00741  Tetracaine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN2A)
     Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN3A)
     Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN4A)
     Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN5A)
     Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN8A)
     Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN9A)
     Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN10A)
     Tetracaine
      D00741  Tetracaine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00741  Tetracaine hydrochloride
BRITE hierarchy
Other DBs
CAS: 
136-47-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C8y C    25.5966  -17.9141
            2   C7a C    26.8041  -18.6141
            3   C8x C    25.5966  -16.5083
            4   C8x C    24.3891  -18.6141
            5   O7a O    28.0117  -17.9200
            6   O6a O    26.7925  -20.0199
            7   C8x C    24.3891  -15.8140
            8   C8x C    23.1699  -17.9141
            9   C1b C    29.2249  -18.6258
            10  C8y C    23.1699  -16.5083
            11  C1b C    30.4384  -17.9257
            12  N1b N    21.9566  -15.8140
            13  N1c N    31.6517  -18.6315
            14  C1b C    20.7491  -16.5083
            15  C1a C    32.8649  -17.9257
            16  C1a C    31.6457  -20.0315
            17  C1b C    19.5356  -15.8140
            18  C1b C    18.3224  -16.5083
            19  C1a C    17.1090  -15.8140
            20  X   Cl   31.6373  -15.9623
BOND        19
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   17  18 1
            18   18  19 1
            19    8  10 2

» Japanese version   » Back

DBGET integrated database retrieval system