KEGG   DRUG: D00745Help
Entry
D00745                      Drug                                   
Name
Interferon alfa-2a (genetical recombination) (JAN);
Interferon alfa-2a (USAN/INN);
Roferon A (TN)
Formula
C860H1353N227O255S9
Exact mass
19228.7369
Mol weight
19240.8977
Sequence
CDLPQTHSLG SRRTLMLLAQ MRKISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI
QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR
KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE
  Type
Peptide
Activity
Antineoplastic;
Biological response modifier [DS:H00004 H00021 H00034 H00038 H00045]
Remark
ATC code: 
Target
interferon receptor 1 agonist [HSA:3454] [KO:K05130];
interferon receptor 2 agonist [HSA:3455] [KO:K05131]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa05160  Hepatitis C  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB04 Interferon alfa-2a
      D00745  Interferon alfa-2a (genetical recombination) (JAN); Interferon alfa-2a (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class II cytokine receptors (interferon/IL-10 family receptors)
   interferon receptor 1 [HSA:3454] [KO:K05130]
    Interferon alfa-2a [ATC:L03AB04]
     D00745  Interferon alfa-2a (genetical recombination) (JAN); Interferon alfa-2a (USAN/INN)
   interferon receptor 2 [HSA:3455] [KO:K05131]
    Interferon alfa-2a [ATC:L03AB04]
     D00745  Interferon alfa-2a (genetical recombination) (JAN); Interferon alfa-2a (USAN/INN)
Antineoplastics [BR:br08308]
 Biologic response modifiers
  Interferones
   Interferon alfa-2a [ATC:L03AB04]
    D00745  Interferon alfa-2a (genetical recombination) (JAN); Interferon alfa-2a (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
76543-88-9
PubChem: 
DrugBank: 

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