KEGG   DRUG: D00756Help
Entry
D00756                      Drug                                   

Name
Tetrahydrozoline nitrate (JAN);
Narbel (TN)
Formula
C13H16N2. HNO3
Exact mass
263.127
Mol weight
263.2924
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Adrenergic [vasoconstrictor]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA06 Tetryzoline
      D00756  Tetrahydrozoline nitrate (JAN)
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB03 Tetryzoline
      D00756  Tetrahydrozoline nitrate (JAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GA Sympathomimetics used as decongestants
     S01GA02 Tetryzoline
      D00756  Tetrahydrozoline nitrate (JAN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Respiratory Tract Agents, Other
   Tetrahydrozoline
    D00756  Tetrahydrozoline nitrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1324  Otolaryngologic vasoconstrictors
     D00756  Tetrahydrozoline nitrate (JAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for otolaryngologic use
  70 Nasal sprays for inflammation
   D00756  Tetrahydrozoline nitrate (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Tetryzoline
    D00756  Tetrahydrozoline nitrate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Tetryzoline
      D00756  Tetrahydrozoline nitrate (JAN)
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        19
            1   C8x C    12.8100  -18.6900
            2   C8x C    12.8100  -17.2900
            3   C8x C    14.0000  -16.5900
            4   C8y C    15.2600  -17.2900
            5   C8y C    15.2600  -18.6900
            6   C8x C    14.0000  -19.3900
            7   C1y C    16.4500  -16.5900
            8   C1x C    17.6400  -17.2900
            9   C1x C    17.6400  -18.6900
            10  C1x C    16.4500  -19.3900
            11  C2y C    16.4500  -15.1900
            12  N2x N    15.3300  -14.3500
            13  C1x C    15.7500  -13.0200
            14  C1x C    17.1500  -13.0200
            15  N1x N    17.5700  -14.3500
            16  O3a O    21.4200  -16.8000
            17  N2b N    21.4200  -18.2000 #+
            18  O1b O    20.1600  -18.9000
            19  O3a O    22.6100  -18.9000 #-
BOND        20
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    7  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   11  15 1
            18   16  17 2
            19   17  18 1
            20   17  19 1

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