KEGG   DRUG: D00774Help
Entry
D00774                      Drug                                   

Name
Orphenadrine citrate (USP);
Norflex (TN)
Product
  Generic
ORPHENADRINE CITRATE (A-S Medication Solutions LLC), ORPHENADRINE CITRATE (Aidarex Pharmaceuticals LLC), ORPHENADRINE CITRATE (Akorn), ORPHENADRINE CITRATE (AvKARE), ORPHENADRINE CITRATE (Bryant Ranch Prepack), ORPHENADRINE CITRATE (Carilion Materials Management), ORPHENADRINE CITRATE (Clinical Solutions Wholesale), ORPHENADRINE CITRATE (Direct RX), ORPHENADRINE CITRATE (Dispensing Solutions), ORPHENADRINE CITRATE (Eon Labs), ORPHENADRINE CITRATE (Gavis Pharmaceuticals), ORPHENADRINE CITRATE (Global Pharmaceuticals), ORPHENADRINE CITRATE (H.J. Harkins Company), ORPHENADRINE CITRATE (Lake Erie Medical DBA Quality Care Products LLC), ORPHENADRINE CITRATE (Lake Erie Medical DBA Quality Care Products LLC), ORPHENADRINE CITRATE (PD-Rx Pharmaceuticals), ORPHENADRINE CITRATE (PD-Rx Pharmaceuticals), ORPHENADRINE CITRATE (Physicians Total Care), ORPHENADRINE CITRATE (Preferred Pharmaceuticals), ORPHENADRINE CITRATE (Preferred Pharmaceuticals), ORPHENADRINE CITRATE (Rebel Distributors Corp), ORPHENADRINE CITRATE (STAT RX USA LLC), ORPHENADRINE CITRATE (STAT Rx USA LLC), ORPHENADRINE CITRATE (Sagent Pharmaceuticals), ORPHENADRINE CITRATE (Unit Dose Services), ORPHENADRINE CITRATE (Watson Laboratories)
Formula
C18H23NO. C6H8O7
Exact mass
461.205
Mol weight
461.5048
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic;
Relaxant [skeletal muscle]
Remark
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M03 MUSCLE RELAXANTS
   M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
    M03BC Ethers, chemically close to antihistamines
     M03BC01 Orphenadrine (citrate)
      D00774  Orphenadrine citrate (USP)
USP drug classification [BR:br08302]
 Skeletal Muscle Relaxants
  Orphenadrine
   D00774  Orphenadrine citrate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Orphenadrine (citrate)
      D00774  Orphenadrine citrate (USP)
BRITE hierarchy
Other DBs
CAS: 
4682-36-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C1d C    30.7401  -20.6868
            2   C1b C    29.5286  -21.3832
            3   C1b C    31.9516  -21.3772
            4   C6a C    31.4307  -19.4693
            5   O1a O    30.0318  -19.4693
            6   C6a C    28.3229  -20.6926
            7   C6a C    31.9399  -22.7762
            8   O6a O    30.7225  -18.2521
            9   O6a O    32.8354  -19.4693
            10  O6a O    27.1115  -21.3949
            11  O6a O    28.3812  -19.2939
            12  O6a O    33.1515  -23.4785
            13  O6a O    30.7225  -23.4726
            14  C1a C    15.8780  -22.1988
            15  N1c N    17.0919  -21.4980
            16  C1b C    18.3057  -22.1988
            17  C1b C    19.5196  -21.4980
            18  O2a O    20.7334  -22.1988
            19  C1c C    21.9472  -21.4980
            20  C8y C    23.1611  -22.1988
            21  C8y C    21.9472  -20.0965
            22  C8x C    23.1483  -19.4030
            23  C8x C    23.1482  -18.0013
            24  C8x C    21.9343  -17.3006
            25  C8x C    20.7333  -17.9941
            26  C8y C    20.7334  -19.3958
            27  C8x C    23.1611  -23.6005
            28  C8x C    24.3750  -24.3013
            29  C8x C    25.5889  -23.6005
            30  C8x C    25.5889  -22.1988
            31  C8x C    24.3750  -21.4980
            32  C1a C    19.5237  -20.0943
            33  C1a C    17.0919  -20.0964
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     6  10 1
            10    6  11 2
            11    7  12 1
            12    7  13 2
            13   14  15 1
            14   15  16 1
            15   16  17 1
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   19  21 1
            20   21  22 2
            21   22  23 1
            22   23  24 2
            23   24  25 1
            24   25  26 2
            25   21  26 1
            26   20  27 1
            27   27  28 2
            28   28  29 1
            29   29  30 2
            30   30  31 1
            31   20  31 2
            32   26  32 1
            33   15  33 1

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